Ocular and cardiovascular effects of local and systemic pindolol.

Ocular and cardiovascular effects of topical and intravenous pindolol have been studied in a balanced cross-0ver double-blind trial in 6 healthy volunteers. When applied to 1 eye pindolol lowered intraocular pressure in both the treated and untreated eyes with only minimal reduction in resting pupil diameter and light reflex response. The concentration in plasma was much lower and inhibiton of exercise tachycardia about half that when the same dose was administered intravenously. The findings suggest that beta-adrenoceptor blocking drugs should not be used in the treatment of glaucoma in patients who also suffer from heart failure.

[1]  S. Smith,et al.  Factors determining the potency of cholinomimetic miotic drugs and their effect upon the light reflex in man. , 1978, British journal of clinical pharmacology.

[2]  S. Gore,et al.  Atenolol eye drops in glaucoma: a double-masked, controlled study. , 1977, The British journal of ophthalmology.

[3]  T. Zimmerman,et al.  Timolol: A β-Adrenergic Blocking Agent for the Treatment of Glaucoma , 1977 .

[4]  London,et al.  Editorial: A sympathetic approach to open-angle glaucoma. , 1975, British Journal of Ophthalmology.

[5]  I. Bonomi,et al.  Effect of pindolol on intraocular pressure. , 1975, The British journal of ophthalmology.

[6]  R. Gugler,et al.  The effect of pindolol on exercise‐induced cardiac acceleration in relation to plasma levels in man , 1975, Clinical pharmacology and therapeutics.

[7]  M. Hills,et al.  A comparison of intravenous pindolol and propranolol in normal man. , 1972, The Journal of clinical pharmacology and new drugs.

[8]  R. Kern.  [The adrenergic receptors of the intraocular muscles of man. An in vitro-study]. , 1970, Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology.

[9]  G. Willetts.  Autonomic effector drugs and the normal human eye. , 1969, American journal of ophthalmology.

[10]  C. Phillips,et al.  Propranolol as ocular hypotensive agent. , 1967, The British journal of ophthalmology.

[11]  A. Herxheimer.  A comparison of some atropine-like drugs in man, with particular reference to their end-organ specificity. , 1958, British journal of pharmacology and chemotherapy.

[12]  E. Prijot,et al.  On the ophthalmotonic consensual reaction and its relationship to aqueous humor dynamics. , 1956, American journal of ophthalmology.

[13]  S. Hoerr.  Diseases of the pancreas. , 1955, Postgraduate medicine.