Edinburgh Research Explorer Gene-environment interactions involving functional variants: Results from the Breast Cancer Association Consortium

Therefore, in the present analyses, multiplicative gene(cid:4)environment interaction in relation to breast cancer risk was assessed between 55 potentially causal as well as 15 newly identified SNP alleles, and the following 11 established epidemiological risk factors: age at menarche, oral contraceptive (OC) use, parity, age at first full(cid:4)term pregnancy (FTP), number of FTPs, breastfeeding, use of menopausal hormone therapy (MHT), body mass index (BMI), adult height, smoking and alcohol consumption. We also investigated interactions in relation to estrogen receptor (ER) specific breast cancer risk since the different disease subtypes may arise through different pathways. The analyses reported in this paper are based on the largest, currently available dataset with genetic data and extensive epidemiological information.

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