Drug History Overrides Opioid Reinforcement in a Rat Runway Procedure

To determine the effect of the drug history of rats on their subsequent operant behaviour in the rat runway procedure, we tested the mu opioid receptor agonists morphine and remifentanil and found a carryover of previous drug/saline experience that was not found for a food reinforcer. Previous exposure to saline significantly decreased the apparent reinforcing effect of subsequently offered morphine or remifentanil, while previous experience with morphine or remifentanil significantly increased responding for saline. This carryover of a previous learning experience on subsequent operant performance in the rat runway procedure cautions that the drug history should be considered and might even invalidate subsequent findings when testing drugs of abuse or other reinforcers.

[1]  R. Wise,et al.  Fluctuations in nucleus accumbens dopamine concentration during intravenous cocaine self-administration in rats , 1995, Psychopharmacology.

[2]  D. Reboussin,et al.  The effects of behavioral history on cocaine self-administration by rhesus monkeys , 1994, Psychopharmacology.

[3]  J. Glowa,et al.  Effects of drug history on the acquisition of responding maintained by GBR 12909 in rhesus monkeys , 2005, Psychopharmacology.

[4]  Seyed Hasan Firoozabadi,et al.  Effects of nitric oxide on morphine self-administration in rat , 2003, Pharmacology Biochemistry and Behavior.

[5]  Z. Justinova,et al.  Self-administration of Delta(9)-tetrahydrocannabinol (THC) bydrug naive squirrel monkeys , 2004 .

[6]  G. Wakonigg,et al.  Methylenedioxymethamphetamine (MDMA, ‘Ecstasy‘) Serves as a Robust Positive Reinforcer in a Rat Runway Procedure , 2003, Pharmacology.

[7]  J. Manzanares,et al.  Extinction of cocaine self-administration produces alterations in corticotropin releasing factor gene expression in the paraventricular nucleus of the hypothalamus. , 2003, Brain research. Molecular brain research.

[8]  S. Goldberg,et al.  Intravenous self-administration of morphine and cocaine: a comparative study. , 2003, Polish journal of pharmacology.

[9]  S. Goldberg,et al.  Self-administration of Δ9-tetrahydrocannabinol (THC) by drug naive squirrel monkeys , 2003, Psychopharmacology.

[10]  G. Wakonigg,et al.  Opioids, cocaine, and food change runtime distribution in a rat runway procedure , 2003, Psychopharmacology.

[11]  J. Lizcano,et al.  Protective effect of N‐(2‐propynyl)‐2‐(5‐benzyloxy‐indolyl) methylamine (PF 9601N), a novel MAO‐B inhibitor, on dopamine‐lesioned PC12 cultured cells , 2003, The Journal of pharmacy and pharmacology.

[12]  B. Rocha,et al.  Behavioural sensitization and enhanced dopamine response in the nucleus accumbens after intravenous cocaine self‐administration in mice , 2003, The European journal of neuroscience.

[13]  K. Mcfarland,et al.  Effects of haloperidol on cue-induced autonomic and behavioral indices of heroin reward and motivation , 2003, Psychopharmacology.

[14]  W. J. Lynch,et al.  Increases in the reinforcing efficacy of cocaine after particular histories of reinforcement , 2002, Behavioural pharmacology.

[15]  R. Shull,et al.  Response-independent milk delivery enhances persistence of pellet-reinforced lever pressing by rats. , 2001, Journal of the experimental analysis of behavior.

[16]  A. Saria,et al.  Reinforcing Effects of MDMA (‘Ecstasy’) in Drug-Naive and Cocaine-Trained Rats , 2001, Pharmacology.

[17]  A. Saria,et al.  Lack of Reinforcing Effect of the Benzodiazepine and Tricyclic Antidepressant Combination of Diazepam and Dothiepin , 2001, Pharmacology.

[18]  G F Koob,et al.  Transition from moderate to excessive drug intake: change in hedonic set point. , 1998, Science.

[19]  D. Landry,et al.  A catalytic antibody against cocaine prevents cocaine's reinforcing and toxic effects in rats. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[20]  A. Ettenberg,et al.  Concurrent Positive and Negative Goalbox Events Produce Runway Behaviors Comparable to Those of Cocaine-Reinforced Rats , 1997, Pharmacology Biochemistry and Behavior.

[21]  S. Comer,et al.  Effects of buprenorphine and naltrexone on reinstatement of cocaine-reinforced responding in rats. , 1993, The Journal of pharmacology and experimental therapeutics.

[22]  R. Depoortère,et al.  Tolerance to self-administration of cocaine in rats: time course and dose-response determination using a multi-dose method. , 1993, Drug and alcohol dependence.

[23]  Timothy D. Geist,et al.  A simple method for studying intravenous drug reinforcement in a runway , 1990, Pharmacology Biochemistry and Behavior.

[24]  U. Ungerstedt,et al.  Cocaine reinforcement and extracellular dopamine overflow in rat nucleus accumbens: an in vivo microdialysis study , 1989, Brain Research.

[25]  C. Schuster,et al.  An analysis of drug-seeking behavior in animals , 1981, Neuroscience & Biobehavioral Reviews.

[26]  J. Woods Narcotic-reinforced responding: a rapid evaluation procedure. , 1980, Drug and alcohol dependence.

[27]  R. Collins,et al.  Self-administration of morphine in the rat: Relative influence of fixed ratio and time-out , 1978, Pharmacology, Biochemistry and Behavior.

[28]  C. Schuster,et al.  Effects of repeated administration of cocaine on schedule-controlled behavior of rats , 1978, Pharmacology Biochemistry and Behavior.