Ophiopogonin D modulates multiple oncogenic signaling pathways, leading to suppression of proliferation and chemosensitization of human lung cancer cells.
暂无分享,去创建一个
G. Sethi | K. Ahn | J. Um | Jong Hyun Lee | Seok-Geun Lee | Chulwon Kim | W. Yang
[1] G. Sethi,et al. 2,5-Dihydroxyacetophenone Induces Apoptosis of Multiple Myeloma Cells by Regulating the MAPK Activation Pathway , 2017, Molecules.
[2] G. Sethi,et al. Isorhynchophylline, a Potent Plant Alkaloid, Induces Apoptotic and Anti-Metastatic Effects in Human Hepatocellular Carcinoma Cells through the Modulation of Diverse Cell Signaling Cascades , 2017, International journal of molecular sciences.
[3] G. Sethi,et al. Ginkgolic Acid C 17:1, Derived from Ginkgo biloba Leaves, Suppresses Constitutive and Inducible STAT3 Activation through Induction of PTEN and SHP-1 Tyrosine Phosphatase , 2017, Molecules.
[4] A. Bishayee,et al. Bioactive natural products in cancer prevention and therapy: Progress and promise. , 2016, Seminars in cancer biology.
[5] A. Bishayee,et al. Cancer prevention and therapy through the modulation of transcription factors by bioactive natural compounds. , 2016, Seminars in cancer biology.
[6] Hui Chen,et al. MDM2 knockdown mediated by a triazine-modified dendrimer in the treatment of non-small cell lung cancer , 2016, Oncotarget.
[7] Ran Wang,et al. Stellettin B Induces G1 Arrest, Apoptosis and Autophagy in Human Non-small Cell Lung Cancer A549 Cells via Blocking PI3K/Akt/mTOR Pathway , 2016, Scientific Reports.
[8] Ge Liu,et al. A novel polysaccharide from Sargassum integerrimum induces apoptosis in A549 cells and prevents angiogensis in vitro and in vivo , 2016, Scientific Reports.
[9] Yuguang Wang,et al. Ophiopogonin D maintains Ca2+ homeostasis in rat cardiomyocytes in vitro by upregulating CYP2J3/EETs and suppressing ER stress , 2016, Acta Pharmacologica Sinica.
[10] Cheng Huang,et al. Ophiopogonin D inhibits cell proliferation, causes cell cycle arrest at G2/M, and induces apoptosis in human breast carcinoma MCF-7 cells. , 2016, Journal of integrative medicine.
[11] Basappa,et al. A novel 4,6-disubstituted-1,2,4-triazolo-1,3,4-thiadiazole derivative inhibits tumor cell invasion and potentiates the apoptotic effect of TNFα by abrogating NF-κB activation cascade , 2016, Apoptosis.
[12] G. Sethi,et al. Targeting the PI3K/Akt signaling pathway in gastric carcinoma: A reality for personalized medicine? , 2015, World journal of gastroenterology.
[13] Jihua Liu,et al. Ophiopogonin-D suppresses MDA-MB-435 cell adhesion and invasion by inhibiting matrix metalloproteinase-9. , 2015, Molecular medicine reports.
[14] G. Sethi,et al. Analysis of the intricate relationship between chronic inflammation and cancer. , 2015, The Biochemical journal.
[15] G. Sethi,et al. Natural Bioactives in Cancer Treatment and Prevention , 2015, BioMed research international.
[16] Gautam Sethi,et al. NF-κB in cancer therapy , 2015, Archives of Toxicology.
[17] Xinmin Zhang,et al. Ophiopogonin D Attenuates Doxorubicin-Induced Autophagic Cell Death by Relieving Mitochondrial Damage In Vitro and In Vivo , 2015, The Journal of Pharmacology and Experimental Therapeutics.
[18] Xiaoyu Ding,et al. [Ophiopogonin D protects cardiomyocytes against doxorubicin-induced injury through suppressing endoplasmic reticulum stress]. , 2014, Yao xue xue bao = Acta pharmaceutica Sinica.
[19] B. Aggarwal,et al. Piperlongumine Chemosensitizes Tumor Cells through Interaction with Cysteine 179 of IκBα Kinase, Leading to Suppression of NF-κB–Regulated Gene Products , 2014, Molecular Cancer Therapeutics.
[20] M. Prato,et al. Involvement of p38 MAPK in haemozoin‐dependent MMP‐9 enhancement in human monocytes , 2014, Cell biochemistry and function.
[21] K. Ahn,et al. Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-κB regulated gene products in multiple myeloma xenograft mouse model , 2013, Oncotarget.
[22] G. Sethi,et al. β-Caryophyllene oxide potentiates TNFα-induced apoptosis and inhibits invasion through down-modulation of NF-κB-regulated gene products , 2013, Apoptosis.
[23] G. Sethi,et al. Natural Bioactives and Phytochemicals Serve in Cancer Treatment and Prevention , 2013, Evidence-based complementary and alternative medicine : eCAM.
[24] Shun-Fa Yang,et al. Selaginella tamariscina (Beauv.) possesses antimetastatic effects on human osteosarcoma cells by decreasing MMP-2 and MMP-9 secretions via p38 and Akt signaling pathways. , 2013, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
[25] A. Hobisch,et al. Sorafenib decreases proliferation and induces apoptosis of prostate cancer cells by inhibition of the androgen receptor and Akt signaling pathways , 2012, Endocrine-related cancer.
[26] G. Sethi,et al. Multifaceted link between cancer and inflammation. , 2012, Bioscience reports.
[27] G. Sethi,et al. Targeting Cell Signaling and Apoptotic Pathways by Dietary Agents: Role in the Prevention and Treatment of Cancer , 2011, Nutrition and cancer.
[28] B. Aggarwal,et al. Noscapine, a benzylisoquinoline alkaloid, sensitizes leukemic cells to chemotherapeutic agents and cytokines by modulating the NF-kappaB signaling pathway. , 2010, Cancer research.
[29] Z. Yin,et al. Ophiopogonin D prevents H2O2-induced injury in primary human umbilical vein endothelial cells. , 2010, Journal of ethnopharmacology.
[30] G. Sethi,et al. Potential pharmacological control of the NF-κB pathway. , 2009, Trends in pharmacological sciences.
[31] F. Khuri,et al. Perspectives for cancer prevention with natural compounds. , 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[32] S. Katiyar,et al. Inhibition of non‐small cell lung cancer cell migration by grape seed proanthocyanidins is mediated through the inhibition of nitric oxide, guanylate cyclase, and ERK1/2 , 2009, Molecular carcinogenesis.
[33] Serge Eifes,et al. Modulation of anti-apoptotic and survival pathways by curcumin as a strategy to induce apoptosis in cancer cells. , 2008, Biochemical pharmacology.
[34] B. Aggarwal,et al. Modification of cysteine residue in p65 subunit of nuclear factor-kappaB (NF-kappaB) by picroliv suppresses NF-kappaB-regulated gene products and potentiates apoptosis. , 2008, Cancer research.
[35] J. Kou,et al. Antithrombotic activities of aqueous extract from Radix Ophiopogon japonicus and its two constituents. , 2006, Biological & pharmaceutical bulletin.
[36] S. Thibodeau,et al. Clinical features of 5,628 primary lung cancer patients: experience at Mayo Clinic from 1997 to 2003. , 2005, Chest.
[37] Qiang Xu,et al. Anti-inflammatory activities of aqueous extract from Radix Ophiopogon japonicus and its two constituents. , 2005, Biological & pharmaceutical bulletin.
[38] James B. Mitchell,et al. Nuclear Factor-κB is an Important Modulator of the Altered Gene Expression Profile and Malignant Phenotype in Squamous Cell Carcinoma , 2004, Cancer Research.
[39] D. Merlin,et al. IL-6 Induces NF-κB Activation in the Intestinal Epithelia 1 , 2003, The Journal of Immunology.
[40] G. Martin,et al. Cell signaling and cancer. , 2003, Cancer cell.
[41] David J Newman,et al. Natural products as sources of new drugs over the period 1981-2002. , 2003, Journal of natural products.
[42] S. Steinberg,et al. Altered cJUN expression: an early event in human lung carcinogenesis. , 1996, Cancer research.