Inflammatory and oxidative stress phenotypes in transgenic sickle cell mice.

[1]  G. Vercellotti,et al.  Control of Oxidative Stress and Inflammation in Sickle Cell Disease with the Nrf2 Activator Dimethyl Fumarate. , 2017, Antioxidants & redox signaling.

[2]  J. Elion,et al.  Men with Sickle Cell Anemia and Priapism Exhibit Increased Hemolytic Rate, Decreased Red Blood Cell Deformability and Increased Red Blood Cell Aggregate Strength , 2016, PloS one.

[3]  S. Ofori-Acquah,et al.  Original Research: Diametric effects of hypoxia on pathophysiology of sickle cell disease in a murine model , 2016, Experimental biology and medicine.

[4]  J. Detterich,et al.  The role of blood rheology in sickle cell disease. , 2016, Blood reviews.

[5]  W. Staines,et al.  Total protein or high-abundance protein: Which offers the best loading control for Western blotting? , 2016, Analytical biochemistry.

[6]  Jianwen Cai,et al.  Monocytosis is associated with hemolysis in sickle cell disease , 2015, Hematology.

[7]  V. Pialoux,et al.  Oxidative stress is decreased in physically active sickle cell SAD mice , 2015, British journal of haematology.

[8]  R. Hebbel,et al.  Sickle cell disease: renal manifestations and mechanisms , 2015, Nature Reviews Nephrology.

[9]  V. Pialoux,et al.  Chronic physical activity limits blood rheology alterations in transgenic SAD mice , 2015, American journal of hematology.

[10]  G. Vercellotti,et al.  Phenotypic Characterization the Townes Sickle Mice , 2014 .

[11]  O. Hue,et al.  Haemolysis and abnormal haemorheology in sickle cell anaemia , 2014, British journal of haematology.

[12]  S. Ofori-Acquah,et al.  Extracellular hemin crisis triggers acute chest syndrome in sickle mice. , 2013, The Journal of clinical investigation.

[13]  R. Pawlinski,et al.  Interplay between coagulation and vascular inflammation in sickle cell disease , 2013, British journal of haematology.

[14]  E. Secor,et al.  Splenic morphological changes are accompanied by altered baseline immunity in a mouse model of sickle-cell disease. , 2012, The American journal of pathology.

[15]  D. Kirchhofer,et al.  Tissue factor promotes activation of coagulation and inflammation in a mouse model of sickle cell disease. , 2012, Blood.

[16]  S. Ofori-Acquah,et al.  Spatiotemporal Dysfunction of the Vascular Permeability Barrier in Transgenic Mice with Sickle Cell Disease , 2012, Anemia.

[17]  V. Pialoux,et al.  Exercise training blunts oxidative stress in sickle cell trait carriers. , 2012, Journal of applied physiology.

[18]  M. Gladwin,et al.  Cardiovascular abnormalities in sickle cell disease. , 2012, Journal of the American College of Cardiology.

[19]  V. Pialoux,et al.  Role of oxidative stress in the pathogenesis of sickle cell disease , 2012, IUBMB life.

[20]  B. Biemond,et al.  Oxidative stress in sickle cell disease; pathophysiology and potential implications for disease management , 2011, American journal of hematology.

[21]  Fermín Sánchez de Medina,et al.  Reversible Ponceau staining as a loading control alternative to actin in Western blots. , 2010, Analytical biochemistry.

[22]  J. Grande,et al.  Early and prominent alterations in hemodynamics, signaling, and gene expression following renal ischemia in sickle cell disease. , 2010, American journal of physiology. Renal physiology.

[23]  M. Gladwin,et al.  Establishment of a transgenic sickle-cell mouse model to study the pathophysiology of priapism. , 2009, The journal of sexual medicine.

[24]  H. Meiselman,et al.  A novel human gamma-globin gene vector for genetic correction of sickle cell anemia in a humanized sickle mouse model: critical determinants for successful correction. , 2009, Blood.

[25]  Tamas Alexy,et al.  Red blood cell aggregation, aggregate strength and oxygen transport potential of blood are abnormal in both homozygous sickle cell anemia and sickle-hemoglobin C disease , 2009, Haematologica.

[26]  Y. Kohgo,et al.  Body iron metabolism and pathophysiology of iron overload , 2008, International journal of hematology.

[27]  Hui Jiang,et al.  How is mRNA expression predictive for protein expression? A correlation study on human circulating monocytes. , 2008, Acta biochimica et biophysica Sinica.

[28]  M. Gladwin,et al.  Sickle cell disease vasculopathy: a state of nitric oxide resistance. , 2008, Free radical biology & medicine.

[29]  C. Moore,et al.  Coagulation activation and inflammation in sickle cell disease-associated pulmonary hypertension , 2008, Haematologica.

[30]  B. Freeman,et al.  Redox-dependent impairment of vascular function in sickle cell disease. , 2007, Free radical biology & medicine.

[31]  N. Dowling,et al.  Sickle cell trait and the risk of venous thromboembolism among blacks. , 2007, Blood.

[32]  J. Anetor,et al.  Total antioxidants status and some hematological values in sickle cell disease patients in steady state. , 2007, Journal of the National Medical Association.

[33]  F. Costa,et al.  Leukocyte numbers correlate with plasma levels of granulocyte–macrophage colony-stimulating factor in sickle cell disease , 2007, Annals of Hematology.

[34]  M. Gladwin,et al.  Hemolysis in sickle cell mice causes pulmonary hypertension due to global impairment in nitric oxide bioavailability. , 2006, Blood.

[35]  T. Townes,et al.  Correction of sickle cell disease by homologous recombination in embryonic stem cells. , 2006, Blood.

[36]  L. Otterbein,et al.  Heme oxygenase-1 is a modulator of inflammation and vaso-occlusion in transgenic sickle mice. , 2006, The Journal of clinical investigation.

[37]  C. Bodian,et al.  Pathology of Berkeley sickle cell mice: similarities and differences with human sickle cell disease. , 2006, Blood.

[38]  D. Granger,et al.  Endothelial cell NADPH oxidase mediates the cerebral microvascular dysfunction in sickle cell transgenic mice , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[39]  R. Nagel,et al.  Effect of fetal hemoglobin on microvascular regulation in sickle transgenic-knockout mice. , 2004, The Journal of clinical investigation.

[40]  J. D. Holtzclaw,et al.  Enhanced pulmonary and systemic response to endotoxin in transgenic sickle mice. , 2004, American journal of respiratory and critical care medicine.

[41]  B. Freeman,et al.  Oxidant-mediated impairment of nitric oxide signaling in sickle cell disease--mechanisms and consequences. , 2004, Cellular and molecular biology.

[42]  R. Korbut,et al.  Nitric oxide and superoxide in inflammation and immune regulation. , 2003, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

[43]  Xueji Zhang,et al.  Measurement of Nitric Oxide Production in Biological Systems by Using Griess Reaction Assay , 2003 .

[44]  J. Bischof,et al.  Transgenic sickle mice have vascular inflammation. , 2003, Blood.

[45]  R. Rodrigo,et al.  Renal damage mediated by oxidative stress: a hypothesis of protective effects of red wine. , 2002, Free radical biology & medicine.

[46]  F. Rosner,et al.  Myocardial infarction in sickle cell disease. , 2002, Journal of the National Medical Association.

[47]  P. Williamson,et al.  Coagulation changes in individuals with sickle cell trait , 2002, American journal of hematology.

[48]  Thomas D. Schmittgen,et al.  Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. , 2001, Methods.

[49]  T. Rassaf,et al.  Plasma nitrite rather than nitrate reflects regional endothelial nitric oxide synthase activity but lacks intrinsic vasodilator action , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[50]  J. Grande,et al.  Oxidative stress and induction of heme oxygenase-1 in the kidney in sickle cell disease. , 2001, The American journal of pathology.

[51]  R. Nagel,et al.  Impaired nitric oxide-mediated vasodilation in transgenic sickle mouse. , 2000, American journal of physiology. Heart and circulatory physiology.

[52]  G. Poli Pathogenesis of liver fibrosis: role of oxidative stress. , 2000, Molecular aspects of medicine.

[53]  H. Schmidt,et al.  Endothelial Nitric-oxide Synthase (Type III) Is Activated and Becomes Calcium Independent upon Phosphorylation by Cyclic Nucleotide-dependent Protein Kinases* , 2000, The Journal of Biological Chemistry.

[54]  J. Laver,et al.  Granulocytosis causing sickle-cell crisis , 1998, The Lancet.

[55]  E. Rubin,et al.  Transgenic knockout mice with exclusively human sickle hemoglobin and sickle cell disease. , 1997, Science.

[56]  S. Ballas,et al.  Pathophysiology of vaso-occlusion. , 1996, Hematology/oncology clinics of North America.

[57]  R. Nagel,et al.  Renal nitric oxide synthases in transgenic sickle cell mice. , 1996, Kidney international.

[58]  P. Jungers,et al.  Advanced oxidation protein products as a novel marker of oxidative stress in uremia. , 1996, Kidney international.

[59]  J. Hofrichter,et al.  A second generation transgenic mouse model expressing both hemoglobin S (HbS) and HbS-Antilles results in increased phenotypic severity. , 1995, Blood.

[60]  R. Nagel,et al.  High expression of human beta S- and alpha-globins in transgenic mice: hemoglobin composition and hematological consequences. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[61]  P. Romeo,et al.  Towards a transgenic mouse model of sickle cell disease: hemoglobin SAD. , 1991, The EMBO journal.

[62]  J. Eaton,et al.  Exposure of endothelial cells to free heme potentiates damage mediated by granulocytes and toxic oxygen species. , 1991, Laboratory investigation; a journal of technical methods and pathology.

[63]  A. Adekile,et al.  Clinical and Laboratory Features Associated with Persistent Gross Splenomegaly in Nigerian Children with Sickle Cell Anaemia , 1990, Acta paediatrica Scandinavica.

[64]  A. Adekile,et al.  Reduced antioxidant capacity in paediatric patients with homozygous sickle cell disease. , 1989, European journal of clinical nutrition.

[65]  A. Prasad,et al.  Altered amount and activity of superoxide dismutase in sickle cell anemia , 1988, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[66]  M. Stevens,et al.  Acute splenic sequestration and hypersplenism in the first five years in homozygous sickle cell disease. , 1981, Archives of disease in childhood.

[67]  Salil K. Das,et al.  Superoxide Dismutase, Glutathione Peroxidase, Catalase and Lipid Peroxidation of Normal and Sickled Erythrocytes , 1980, British journal of haematology.

[68]  S. Weissman,et al.  Human beta-globin messenger RNA. III. Nucleotide sequences derived from complementary DNA. , 1977, The Journal of biological chemistry.

[69]  G. Serjeant,et al.  Coagulation Changes during the Steady State in Homozygous Sickle‐Cell Disease in Jamaica , 1975, British journal of haematology.

[70]  D. P. Cooney,et al.  The pathophysiology of hypersplenic thrombocytopenia. , 1968, Archives of internal medicine.

[71]  W. Valentine,et al.  Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. , 1967, The Journal of laboratory and clinical medicine.

[72]  E. Rossi,et al.  HYPERSPLENISM IN SICKLE CELL ANEMIA. , 1964, Archives of internal medicine.

[73]  R. Hebbel,et al.  Amendment history : Erratum ( September 2000 ) Hypoxia / reoxygenation causes inflammatory response in transgenic sickle mice but not in normal mice , 2018 .

[74]  Y. Bertrand,et al.  Importance of methodological standardization for the ektacytometric measures of red blood cell deformability in sickle cell anemia. , 2016, Clinical hemorheology and microcirculation.

[75]  E. Lima,et al.  Oxidative stress in sickle cell disease , 2013, Revista brasileira de hematologia e hemoterapia.

[76]  V. Pialoux,et al.  Hypoxia/reoxygenation stress increases markers of vaso-occlusive crisis in sickle SAD mice. , 2013, Clinical hemorheology and microcirculation.

[77]  T. Townes Gene replacement therapy for sickle cell disease and other blood disorders. , 2008, Hematology. American Society of Hematology. Education Program.

[78]  O. Hue,et al.  Blood rheology abnormalities and vascular cell adhesion mechanisms in sickle cell trait carriers during exercise. , 2008, Clinical hemorheology and microcirculation.

[79]  N. Perkins,et al.  Integrating cell-signalling pathways with NF-κB and IKK function , 2007, Nature Reviews Molecular Cell Biology.

[80]  R. Hasanato Zinc and antioxidant vitamin deficiency in patients with severe sickle cell anemia , 2006, Annals of Saudi medicine.

[81]  C. Chow,et al.  Selenium and glutathione peroxidase levels in sickle cell anemia. , 1990, Acta haematologica.

[82]  L. Oberley,et al.  Assay of superoxide dismutase activity in tumor tissue. , 1984, Methods in enzymology.

[83]  N. Mohandas,et al.  Deformability of oxygenated irreversibly sickled cells. , 1980, The Journal of clinical investigation.

[84]  C. Srodes,et al.  An unusual pattern of neutrophil kinetics in sickle cell anemia. , 1973, Blood.