Genetics of Human Taste Perception on Behalf Of: International and American Associations for Dental Research

Genetic approaches are rapidly yielding new information about our sense of taste. This information comes from both molecular studies of genes encoding taste receptors and other taste-signaling components, and from studies of inherited variation in taste abilities. Our understanding of bitter taste has advanced by combined information from discovery and study of the TAS2R family of taste receptor genes, hand in hand with genetic linkage and positional cloning studies, notably on the ability to taste phenylthiocarbamide (PTC). Sweet and umami tastes, mediated by TAS1R receptors, are becoming well-characterized at the molecular genetic level, and these taste classes are now targets for linkage, positional cloning, and genetic association strategies. Salty and sour tastes are still poorly characterized in genetic terms, and represent opportunities for the future.

[1]  K. Tonosaki,et al.  Possible involvement of undissociated acid molecules in the acid response of the chorda tympani nerve of the rat. , 2000, Journal of neurophysiology.

[2]  D. Reed,et al.  The genetics of phenylthiocarbamide perception. , 2001, Annals of human biology.

[3]  L. Bartoshuk,et al.  Effects of capsaicin desensitization on taste in humans , 1995, Physiology & Behavior.

[4]  Xiaodong Li,et al.  Human receptors for sweet and umami taste , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[5]  H. Kalmus,et al.  The measurement of taste sensitivity to phenylthiourea. , 1949, Annals of eugenics.

[6]  P. Ganzevles,et al.  Effects of adaptation and cross-adaptation to common ions on sourness intensity , 1987, Physiology & Behavior.

[7]  A. Faurion,et al.  A new specific ageusia: some humans cannot taste L-glutamate. , 2002, Chemical senses.

[8]  B. Lindemann,et al.  Occurrence of ENaC Subunit mRNA and Immunocytochemistry of the Channel Subunits in Taste Buds of the Rat Vallate Papilla a , 1998, Annals of the New York Academy of Sciences.

[9]  Izabela Makalowska,et al.  Identification of six novel genes by experimental validation of GeneMachine predicted genes. , 2002, Gene.

[10]  H. Kalmus,et al.  Taste thresholds of further eighteen compounds and their correlation with P.T.C thresholds. , 1951, Annals of eugenics.

[11]  P. Odeigah.  Smell acuity for acetone and its relationship to taste ability to phenylthiocarbamide in a Nigerian population. , 1994, East African medical journal.

[12]  B. Simmen,et al.  Taste perception and feeding behavior in nonhuman primates and human populations , 1996 .

[13]  F. Griffin,et al.  Taste thresholds in twins and siblings. , 1967, Acta geneticae medicae et gemellologiae.

[14]  B. Tepper,et al.  Fat Perception is Related to PROP Taster Status , 1997, Physiology & Behavior.

[15]  C. P. Richter.  Self-selection of diets , 1942 .

[16]  Gustatory processing differences in PTC tasters and non-tasters: A reaction time analysis , 1985, Physiology & Behavior.

[17]  Herness Ms,et al.  CELLULAR MECHANISMS OF TASTE TRANSDUCTION , 1999 .

[18]  B. BRANDTZAEG MERTON.  Taste sensitivity to PTC in 60 Norwegian families with 176 children; confirmation of the hypothesis of single gene inheritance. , 1958, Acta genetica et statistica medica.

[19]  H. Kalmus,et al.  Chemical specificity in genetical differences of taste sensitivity. , 1949, Annals of eugenics.

[20]  A. L. Makhlouf GM BLUM.  Kinetics of the taste response to chemical stimulation: a theory of acid taste in man. , 1972, Gastroenterology.

[21]  B. Lindemann,et al.  Taste reception. , 1996, Physiological reviews.

[22]  S. Mizutani,et al.  Insensitivity to the bitter taste of chloramphenicol: an autosomal recessive trait. , 2002, Genes & genetic systems.

[23]  N. Ryba,et al.  The Receptors for Mammalian Sweet and Umami Taste , 2003, Cell.

[24]  P. Breslin,et al.  Covariation in individuals’ sensitivities to bitter compounds: Evidence supporting multiple receptor/transduction mechanisms , 2001, Perception & psychophysics.

[25]  M. Boehnke,et al.  Alternative genetic models for the inheritance of the phenylthiocarbamide taste deficiency , 1989, Genetic epidemiology.

[26]  Michael J Bamshad,et al.  Natural selection and molecular evolution in PTC, a bitter-taste receptor gene. , 2004, American journal of human genetics.

[27]  S. Ugawa.  Identification of sour-taste receptor genes , 2003, Anatomical science international.

[28]  Jianzhi Zhang,et al.  Adaptive diversification of bitter taste receptor genes in Mammalian evolution. , 2003, Molecular biology and evolution.

[29]  P. Breslin,et al.  Reduction of saltiness and bitterness after a chlorhexidine rinse. , 2001, Chemical senses.

[30]  S. Schiffman,et al.  Amiloride reduces the taste intensity of Na+ and Li+ salts and sweeteners. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[31]  G. Gross,et al.  The nature of taste receptor sites. , 1971, Contributions to sensory physiology.

[32]  Sami Damak,et al.  Detection of Sweet and Umami Taste in the Absence of Taste Receptor T1r3 , 2003, Science.

[33]  P. Schultz,et al.  Three sweet receptor genes are clustered in human Chromosome 1 , 2003, Mammalian Genome.

[34]  A. Blakeslee.  Genetics of Sensory Thresholds: Taste for Phenyl Thio Carbamide. , 1932, Proceedings of the National Academy of Sciences of the United States of America.

[35]  Mark Leppert,et al.  Positional Cloning of the Human Quantitative Trait Locus Underlying Taste Sensitivity to Phenylthiocarbamide , 2003, Science.

[36]  Liquan Huang,et al.  Gγ13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium , 1999, Nature Neuroscience.

[37]  Linda M. Bartoshuk,et al.  PTC/PROP tasting: Anatomy, psychophysics, and sex effects , 1994, Physiology & Behavior.

[38]  A. Drewnowski,et al.  Genetic Sensitivity to 6-n-Propylthiouracil and Sensory Responses to Sugar and Fat Mixtures , 1998, Physiology & Behavior.

[39]  G. Beauchamp,et al.  Polymorphisms in the Taste Receptor Gene (Tas1r3) Region Are Associated with Saccharin Preference in 30 Mouse Strains , 2004, The Journal of Neuroscience.

[40]  A. Drewnowski,et al.  Young women's food preferences and taste responsiveness to 6-n-propylthiouracil (PROP) , 2000, Physiology & Behavior.

[41]  H. Coon,et al.  Genetic analysis of a complex trait in the Utah Genetic Reference Project: a major locus for PTC taste ability on chromosome 7q and a secondary locus on chromosome 16p , 2003, Human Genetics.

[42]  V. Duffy,et al.  Propylthiouracil tasting: determination of underlying threshold distributions using maximum likelihood. , 1995, Chemical senses.

[43]  F. Griffin,et al.  PHARMACOGENETIC ASPECTS OF GUSTATION. , 1964, Arzneimittel-Forschung.

[44]  A. Drewnowski,et al.  Nontasters, Tasters, and Supertasters of 6-n-Propylthiouracil (PROP) and Hedonic Response to Sweet , 1997, Physiology & Behavior.

[45]  T. Finger,et al.  Neurobiology of taste and smell , 1987 .

[46]  H. Kalmus,et al.  THE MEASUREMENT OF TASTE SENSITIVITY TO PHENYLTHIOUREA (P.T.C.) , 1949 .

[47]  Dietmar Krautwurst,et al.  The human TAS2R16 receptor mediates bitter taste in response to β-glucopyranosides , 2002, Nature Genetics.

[48]  V. Duffy,et al.  Supertasting, earaches and head injury: Genetics and pathology alter our taste worlds , 1996, Neuroscience & Biobehavioral Reviews.

[49]  I. J. Miller,et al.  Variations in human taste bud density and taste intensity perception , 1990, Physiology & Behavior.

[50]  D. Reed.  Gene mapping for taste related phenotypes in humans and mice , 2000, Appetite.

[51]  A. Blakeslee,et al.  Genetics of Sensory Thresholds: Individual Taste Reactions for Different Substances. , 1935, Proceedings of the National Academy of Sciences of the United States of America.

[52]  R. Schmidt,et al.  Progress in Sensory Physiology , 1991, Progress in Sensory Physiology.

[53]  A. L. Fox.  The Relationship between Chemical Constitution and Taste. , 1932, Proceedings of the National Academy of Sciences of the United States of America.

[54]  Jayaram Chandrashekar,et al.  A Novel Family of Mammalian Taste Receptors , 2000, Cell.

[55]  H. Kalmus,et al.  The distribution of taste thresholds for phenylthiourea of 384 sib pairs. , 1951, Annals of eugenics.

[56]  T. Finger,et al.  Epithelial Na+ channel subunits in rat taste cells: Localization and regulation by aldosterone , 1999, The Journal of comparative neurology.

[57]  R. Cantor,et al.  A genetic analysis of taste threshold for phenylthiocarbamide. , 1981, Acta geneticae medicae et gemellologiae.

[58]  W. D. Neff.  Contributions to sensory physiology , 1965 .

[59]  D. Whissell-Buechy,et al.  Male and female correlations for taster (P.T.C.) phenotypes and rate of adolescent development. , 1989, Annals of human biology.

[60]  M. Krondl,et al.  Genetic influences on the selection of Brassica vegetables by elderly individuals , 1988 .

[61]  T. Gilbertson,et al.  Cellular mechanisms of taste transduction. , 1999, Annual review of physiology.

[62]  A. Faurion.  Physiology of the Sweet Taste , 1987 .

[63]  G. Beauchamp,et al.  Individual differences in sensitivity to bitter-tasting substances , 1993 .

[64]  D. Smith,et al.  Effect of amiloride on the taste of NaCl, Na-gluconate and KCl in humans: implications for Na+ receptor mechanisms. , 1995, Chemical senses.

[65]  B. Lindemann,et al.  Differential Expression of RNA and Protein of the Three Pore-forming Subunits of the Amiloride-sensitive Epithelial Sodium Channel in Taste Buds of the Rat , 1999, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[66]  D. Reed,et al.  The Human Sweet Tooth and Its Relationship to Obesity , 2004 .

[67]  J. Desimone,et al.  Salt taste transduction occurs through an amiloride-sensitive sodium transport pathway. , 1984, Science.

[68]  Y. Zotterman,et al.  A COMPARISON OF NEURAL AND PSYCHOPHYSICAL RESPONSES TO TASTE STIMULI IN MAN. , 1965, Acta physiologica Scandinavica.

[69]  P. Davies,et al.  Quinine taste thresholds: a family study and a twin study , 1973, Annals of human genetics.

[70]  H. Weingarten,et al.  Facial expressions and genetic sensitivity to 6-n-propylthiouracil predict hedonic response to sweet , 1992, Physiology & Behavior.

[71]  N. Ryba,et al.  T2Rs Function as Bitter Taste Receptors , 2000, Cell.