Behavior of host-cell-protein-rich aggregates in antibody capture and polishing chromatography
暂无分享,去创建一个
L. Choe | A. Lenhoff | Xuankuo Xu | Sanchayita Ghose | Lie Min | Ronald W. Maurer | Kelvin H. Lee | Chase E. Herman
[1] L. Choe,et al. Analytical characterization of host‐cell‐protein‐rich aggregates in monoclonal antibody solutions , 2023, Biotechnology progress.
[2] L. Choe,et al. Characterization and implications of host‐cell protein aggregates in biopharmaceutical processing , 2022, Biotechnology and bioengineering.
[3] Chen Qian,et al. Formation of transient highly-charged mAb clusters strengthens interactions with host cell proteins and results in poor clearance of host cell proteins by protein A chromatography. , 2022, Journal of chromatography. A.
[4] Kelvin H. Lee,et al. Comprehensive assessment of host cell protein expression after extended culture and bioreactor production of CHO cell lines , 2022, Biotechnology and bioengineering.
[5] Alana C Szkodny,et al. Biopharmaceutical Manufacturing: Historical Perspectives and Future Directions. , 2022, Annual review of chemical and biomolecular engineering.
[6] G. Gaza-Bulseco,et al. “High‐risk” host cell proteins (HCPs): A multi‐company collaborative view , 2021, Biotechnology and bioengineering.
[7] R. Molden,et al. Host cell protein profiling of commercial therapeutic protein drugs as a benchmark for monoclonal antibody-based therapeutic protein development , 2021, mAbs.
[8] A. Lenhoff,et al. Displacement to separate host‐cell proteins and aggregates in cation‐exchange chromatography of monoclonal antibodies , 2020, Biotechnology and bioengineering.
[9] Kurt Eyer,et al. Chromatographic clarification overcomes chromatin‐mediated hitch‐hiking interactions on Protein A capture column , 2020, Biotechnology and bioengineering.
[10] Z. Li,et al. Strategies for high‐concentration drug substance manufacturing to facilitate subcutaneous administration: A review , 2020, Biotechnology and bioengineering.
[11] M. Morbidelli,et al. Understanding mAb aggregation during low pH viral inactivation and subsequent neutralization , 2019, Biotechnology and bioengineering.
[12] Z. Li,et al. Protein aggregation and mitigation strategy in low pH viral inactivation for monoclonal antibody purification , 2019, mAbs.
[13] J. Bones,et al. Identification and tracking of problematic host cell proteins removed by a synthetic, highly functionalized nonwoven media in downstream bioprocessing of monoclonal antibodies. , 2019, Journal of chromatography. A.
[14] T. Schwab,et al. Mass spectrometric evaluation of upstream and downstream process influences on host cell protein patterns in biopharmaceutical products , 2019, Biotechnology progress.
[15] Xuankuo Xu,et al. DNA RETENTION ON DEPTH FILTERS. , 2019, Journal of membrane science.
[16] Gary Walsh,et al. Biopharmaceutical benchmarks 2018 , 2018, Nature Biotechnology.
[17] Ludovic C. Gillet,et al. Data‐independent acquisition‐based SWATH‐MS for quantitative proteomics: a tutorial , 2018, Molecular systems biology.
[18] Xuankuo Xu,et al. Contributions of depth filter components to protein adsorption in bioprocessing , 2018, Biotechnology and bioengineering.
[19] Timothy M Pabst,et al. Evaluation of recent Protein A stationary phase innovations for capture of biotherapeutics. , 2018, Journal of chromatography. A.
[20] Christine Carapito,et al. Dual Data-Independent Acquisition Approach Combining Global HCP Profiling and Absolute Quantification of Key Impurities during Bioprocess Development. , 2018, Analytical chemistry.
[21] Christopher Gillespie,et al. Integrated flow-through purification for therapeutic monoclonal antibodies processing , 2018, mAbs.
[22] Massimo Morbidelli,et al. Design and operation of a continuous integrated monoclonal antibody production process , 2017, Biotechnology progress.
[23] Lihua Huang,et al. A Novel Sample Preparation for Shotgun Proteomics Characterization of HCPs in Antibodies. , 2017, Analytical chemistry.
[24] Z. Li,et al. Host Cell Protein Profiling by Targeted and Untargeted Analysis of Data Independent Acquisition Mass Spectrometry Data with Parallel Reaction Monitoring Verification. , 2017, Analytical chemistry.
[25] Min Zhu,et al. Effects of antibody disulfide bond reduction on purification process performance and final drug substance stability , 2017, Biotechnology and bioengineering.
[26] A. Shukla,et al. Evolving trends in mAb production processes , 2017, Bioengineering & translational medicine.
[27] M. Xian,et al. A simple and efficient purification platform for monoclonal antibody production based on chromatin-directed cell culture clarification integrated with precipitation and void-exclusion anion exchange chromatography. , 2016, Journal of biotechnology.
[28] Rui Nian,et al. Advance chromatin extraction enhances performance and productivity of cation exchange chromatography-based capture of Immunoglobulin G monoclonal antibodies. , 2016, Journal of chromatography. A.
[29] P. Wright,et al. Quantitative definition and monitoring of the host cell protein proteome using iTRAQ – a study of an industrial mAb producing CHO‐S cell line , 2016, Biotechnology journal.
[30] Abraham M Lenhoff,et al. Host cell protein impurities in chromatographic polishing steps for monoclonal antibody purification , 2016, Biotechnology and bioengineering.
[31] Michael P. Hall,et al. Characterization of the co‐elution of host cell proteins with monoclonal antibodies during protein A purification , 2016, Biotechnology progress.
[32] A. Lenhoff,et al. Characterization of cross-linked cellulosic ion-exchange adsorbents: 2. Protein sorption and transport. , 2016, Journal of chromatography. A.
[33] Yuansheng Yang,et al. Advance chromatin extraction improves capture performance of protein A affinity chromatography. , 2016, Journal of chromatography. A.
[34] Jennifer Halley,et al. Protein A chromatography increases monoclonal antibody aggregation rate during subsequent low pH virus inactivation hold , 2015, Journal of chromatography. A.
[35] Rui Nian,et al. Non-immunospecific association of immunoglobulin G with chromatin during elution from protein A inflates host contamination, aggregate content, and antibody loss. , 2015, Journal of chromatography. A.
[36] D. Ecker,et al. The therapeutic monoclonal antibody market , 2015, mAbs.
[37] Giorgio Carta,et al. Particle size effects on protein and virus-like particle adsorption on perfusion chromatography media. , 2015, Journal of chromatography. A.
[38] Rui Nian,et al. Chromatin-mediated depression of fractionation performance on electronegative multimodal chromatography media, its prevention, and ramifications for purification of immunoglobulin G. , 2014, Journal of chromatography. A.
[39] J. Zhu-Shimoni,et al. Host cell protein testing by ELISAs and the use of orthogonal methods , 2014, Biotechnology and bioengineering.
[40] Gary Walsh,et al. Biopharmaceutical benchmarks 2014 , 2014, Nature Biotechnology.
[41] Brendan MacLean,et al. MSstats: an R package for statistical analysis of quantitative mass spectrometry-based proteomic experiments , 2014, Bioinform..
[42] David Robbins,et al. A Novel Approach to Monitor Clearance of Host Cell Proteins Associated With Monoclonal Antibodies , 2014, Biotechnology progress.
[43] Rui Nian,et al. Nonspecific interactions of chromatin with immunoglobulin G and protein A, and their impact on purification performance. , 2014, Journal of chromatography. A.
[44] Abraham M Lenhoff,et al. Identification and characterization of host cell protein product‐associated impurities in monoclonal antibody bioprocessing , 2014, Biotechnology and bioengineering.
[45] Massimo Morbidelli,et al. Model-based prediction of monoclonal antibody retention in ion-exchange chromatography. , 2013, Journal of chromatography. A.
[46] G. Carta,et al. Protein and virus-like particle adsorption on perfusion chromatography media. , 2013, Journal of chromatography. A.
[47] P. Gagnon,et al. Characterization and removal of aggregates formed by nonspecific interaction of IgM monoclonal antibodies with chromatin catabolites during cell culture production. , 2013, Journal of chromatography. A.
[48] Scott M Husson,et al. Anion exchange membrane adsorbers for flow‐through polishing steps: Part II. Virus, host cell protein, DNA clearance, and antibody recovery , 2013, Biotechnology and bioengineering.
[49] C. Smales,et al. The challenges of product- and process-related impurities to an evolving biopharmaceutical industry. , 2013, Bioanalysis.
[50] Ludovic C. Gillet,et al. Targeted Data Extraction of the MS/MS Spectra Generated by Data-independent Acquisition: A New Concept for Consistent and Accurate Proteome Analysis* , 2012, Molecular & Cellular Proteomics.
[51] J. Chon,et al. Advances in the production and downstream processing of antibodies. , 2011, New biotechnology.
[52] María Vázquez-Rey,et al. Aggregates in monoclonal antibody manufacturing processes , 2011, Biotechnology and bioengineering.
[53] R. Aebersold,et al. mProphet: automated data processing and statistical validation for large-scale SRM experiments , 2011, Nature Methods.
[54] Gary Walsh,et al. Biopharmaceutical benchmarks 2010 , 2010, Nature Biotechnology.
[55] John Hickey,et al. Profiling of host cell proteins by two‐dimensional difference gel electrophoresis (2D‐DIGE): Implications for downstream process development , 2010, Biotechnology and bioengineering.
[56] A. Hunter,et al. Host cell proteins in biologics development: Identification, quantitation and risk assessment , 2009, Biotechnology and bioengineering.
[57] P. Hinckley,et al. Host cell protein clearance during protein a chromatography: Development of an improved column wash step , 2008, Biotechnology progress.
[58] D. Roush,et al. Advances in Primary Recovery: Centrifugation and Membrane Technology , 2008, Biotechnology progress.
[59] Sean L Seymour,et al. The Paragon Algorithm, a Next Generation Search Engine That Uses Sequence Temperature Values and Feature Probabilities to Identify Peptides from Tandem Mass Spectra*S , 2007, Molecular & Cellular Proteomics.
[60] Brian Hubbard,et al. Downstream processing of monoclonal antibodies--application of platform approaches. , 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
[61] Abraham M Lenhoff,et al. Pore size distributions of ion exchangers and relation to protein binding capacity. , 2006, Journal of chromatography. A.
[62] A. Lenhoff,et al. Nondiffusive mechanisms enhance protein uptake rates in ion exchange particles , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[63] D. W. Scott. On optimal and data based histograms , 1979 .