Molecular logic circuits.

Miniaturization has been an essential ingredient in the outstanding progress of information technology over the past fifty years. The next, perhaps ultimate, limit of miniaturization is that of molecules, which are the smallest entities with definite size, shape, and properties. Recently, great effort has been devoted to design and investigate molecular-level systems that are capable of transferring, processing, and storing information in binary form. Some of these nanoscale devices can, in fact, perform logic operations of remarkable complexity. This research--although far from being transferred into technology--is attracting interest, as the nanometer realm seems to be out of reach for the "top-down" techniques currently available to microelectronics industry. Moreover, such studies introduce new concepts in the "old" field of chemistry and stimulate the ingenuity of researchers engaged in the "bottom-up" approach to nanotechnology.

[1]  Terence E. Rice,et al.  Integration of Logic Functions and Sequential Operation of Gates at the Molecular-Scale , 1999 .

[2]  F. Raymo,et al.  Signal processing at the molecular level. , 2001, Journal of the American Chemical Society.

[3]  J. Fraser Stoddart,et al.  Logic Operations at the Molecular Level. An XOR Gate Based on a Molecular Machine , 1997 .

[4]  James M. Tour,et al.  Molecular Scale Electronics: A Synthetic/Computational Approach to Digital Computing , 1998 .

[5]  S. Faulkner,et al.  Parallel Processing in Aqueous Solution , 1999 .

[6]  L. Adleman Computing with DNA , 1998 .

[7]  F. Raymo,et al.  Signal communication between molecular switches. , 2001, Organic letters.

[8]  Françoise Remacle,et al.  On spectroscopy, control, and molecular information processing. , 2002, Chemphyschem : a European journal of chemical physics and physical chemistry.

[9]  Vincenzo Balzani,et al.  Molecular-Level Devices , 1999 .

[10]  J. Tour,et al.  Molecular electronics. Synthesis and testing of components. , 2000, Accounts of chemical research.

[11]  John K. Tomfohr,et al.  Reproducible Measurement of Single-Molecule Conductivity , 2001, Science.

[12]  Robert M. Metzger,et al.  ELECTRICAL RECTIFICATION BY A MOLECULE : THE ADVENT OF UNIMOLECULAR ELECTRONIC DEVICES , 1999 .

[13]  D. Muller,et al.  The electronic structure at the atomic scale of ultrathin gate oxides , 1999, Nature.

[14]  Fernando Pina,et al.  Micelle effect on the ‘write–lock–read–unlock–erase’ cycle of 4′-hydroxyflavylium ion , 1999 .

[15]  J.C. Ellenbogen,et al.  Architectures for molecular electronic computers. I. Logic structures and an adder designed from molecular electronic diodes , 2000, Proceedings of the IEEE.

[16]  C. McCoy,et al.  A molecular photoionic AND gate based on fluorescent signalling , 1993, Nature.

[17]  Lloyd M. Smith,et al.  DNA computing on surfaces , 2000, Nature.

[18]  Darko Stefanovic,et al.  Deoxyribozyme-based logic gates. , 2002, Journal of the American Chemical Society.

[19]  A. P. Silva,et al.  Molecular Photoionic AND Logic Gates with Bright Fluorescence and “Off−On” Digital Action , 1997 .

[20]  Terence E. Rice,et al.  Signaling Recognition Events with Fluorescent Sensors and Switches. , 1997, Chemical reviews.

[21]  R. Levine,et al.  A molecular logic gate. , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[22]  A. P. D. S. and,et al.  Proof-of-Principle of Molecular-Scale Arithmetic , 2000 .

[23]  S. Weiss Fluorescence spectroscopy of single biomolecules. , 1999, Science.

[24]  ARTIFICIAL NEURONS WITH LOGICAL PROPERTIES BASED ON PAIRED-BAND MICROELECTRODE ASSEMBLIES , 1999 .

[25]  Thorfinnur Gunnlaugsson,et al.  Luminescent molecular logic gates: the two-input inhibit (INH) function , 2000 .

[26]  Shi V. Liu Debating controversies can enhance creativity , 2000, Nature.

[27]  J. Tour,et al.  Charge transport through self-assembled monolayers of compounds of interest in molecular electronics. , 2002, Journal of the American Chemical Society.

[28]  F. Raymo,et al.  Digital communication through intermolecular fluorescence modulation. , 2001, Organic letters.

[29]  Fernando Pina,et al.  Artificial Chemical Systems Capable of Mimicking Some Elementary Properties of Neurons , 2000 .

[30]  K Sakamoto,et al.  Molecular computation by DNA hairpin formation. , 2000, Science.

[31]  L M Adleman,et al.  Molecular computation of solutions to combinatorial problems. , 1994, Science.

[32]  Françisco M Raymo,et al.  Multichannel digital transmission in an optical network of communicating molecules. , 2002, Journal of the American Chemical Society.

[33]  J. Gimzewski,et al.  Electronics using hybrid-molecular and mono-molecular devices , 2000, Nature.

[34]  J. Fraser Stoddart,et al.  Computing at the Molecular Level , 2001 .

[35]  R. W. Keyes,et al.  Fundamental limits of silicon technology , 2001, Proc. IEEE.

[36]  G. Whitesides,et al.  Correlating Electron Transport and Molecular Structure in Organic Thin Films. , 2001, Angewandte Chemie.

[37]  Clifford R. Johnson,et al.  Solution of a 20-Variable 3-SAT Problem on a DNA Computer , 2002, Science.

[38]  T. Gunnlaugsson,et al.  Lanthanide macrocyclic quinolyl conjugates as luminescent molecular-level devices. , 2001, Journal of the American Chemical Society.

[39]  J. Reif,et al.  Logical computation using algorithmic self-assembly of DNA triple-crossover molecules , 2000, Nature.

[40]  Kenneth Showalter,et al.  Chemical Wave Logic Gates , 1996 .

[41]  F. Raymo Digital processing and communication with molecular switches , 2002 .

[42]  Tohru Yamamoto,et al.  Two-dimensional molecular electronics circuits. , 2002, Chemphyschem : a European journal of chemical physics and physical chemistry.

[43]  J. Fraser Stoddart,et al.  Electrochemically Induced Molecular Motions in Pseudorotaxanes: A Case of Dual‐Mode (Oxidative and Reductive) Dethreading , 1997 .

[44]  M. Reed Molecular-scale electronics , 1999, Proc. IEEE.