AURANOFIN INCREASES APOPTOSIS AND ISCHAEMIA–REPERFUSION INJURY IN THE RAT ISOLATED HEART

1. Auranofin, an antirheumatic gold compound, is an inhibitor of selenocysteine enzymes, such as thioredoxin reductase and glutathione peroxidase. These enzymes play an important role in protecting cardiac tissue from oxidative stress generated during ischaemia–reperfusion.

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