Superparamagnetic γ-Fe2O3 nanoparticles with tailored functionality for protein separation

Polymer coated superparamagnetic γ-Fe2O3 nanoparticles were derivatized with a synthetic double-stranded RNA [poly(IC)], a known allosteric activator of the latent (2-5)A synthetase, to separate a single 35 kDa protein from a crude extract which cross reacted with antibodies raised against the sponge enzyme.

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