Regulation of glutamine carrier proteins by RNF5 determines breast cancer response to ER stress-inducing chemotherapies.

[1]  Prahlad T. Ram,et al.  A pan-cancer proteomic perspective on The Cancer Genome Atlas , 2014, Nature Communications.

[2]  D. Bowtell,et al.  Fine Tuning of the UPR by the Ubiquitin Ligases Siah1/2 , 2014, PLoS genetics.

[3]  Eric H. Baehrecke,et al.  Self-consumption: the interplay of autophagy and apoptosis , 2014, Nature Reviews Molecular Cell Biology.

[4]  Riccardo Bernasconi,et al.  RETRACTED: Autoadaptive ER-Associated Degradation Defines a Preemptive Unfolded Protein Response Pathway , 2013, Molecular Cell.

[5]  J. Tamburini,et al.  Inhibiting glutamine uptake represents an attractive new strategy for treating acute myeloid leukemia. , 2013, Blood.

[6]  J. Gray,et al.  Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target. , 2013, Cancer cell.

[7]  C. Hetz,et al.  Targeting the unfolded protein response in disease , 2013, Nature Reviews Drug Discovery.

[8]  V. Carraro,et al.  The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression , 2013, Nucleic acids research.

[9]  Sang Gyun Kim,et al.  Nutrient regulation of the mTOR Complex 1 signaling pathway , 2013, Molecules and cells.

[10]  A. Mancuso,et al.  Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress. , 2013, Genes & development.

[11]  T. Pan,et al.  A Self-defeating Anabolic Program Leads to β-Cell Apoptosis in Endoplasmic Reticulum Stress-induced Diabetes via Regulation of Amino Acid Flux* , 2013, The Journal of Biological Chemistry.

[12]  P. Massion,et al.  SLC1A5 Mediates Glutamine Transport Required for Lung Cancer Cell Growth and Survival , 2012, Clinical Cancer Research.

[13]  Boris Ratnikov,et al.  Glutamine‐fueled mitochondrial metabolism is decoupled from glycolysis in melanoma , 2012, Pigment cell & melanoma research.

[14]  V. Nizet,et al.  Regulation of ATG4B Stability by RNF5 Limits Basal Levels of Autophagy and Influences Susceptibility to Bacterial Infection , 2012, PLoS genetics.

[15]  Wei Liu,et al.  Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC , 2012, Proceedings of the National Academy of Sciences.

[16]  P. Walter,et al.  The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation , 2011, Science.

[17]  N. Shikano,et al.  Putative Transport Mechanism and Intracellular Fate of Trans-1-Amino-3-18F-Fluorocyclobutanecarboxylic Acid in Human Prostate Cancer , 2011, The Journal of Nuclear Medicine.

[18]  F. R. Papa,et al.  Signaling cell death from the endoplasmic reticulum stress response. , 2011, Current opinion in cell biology.

[19]  D. Ron,et al.  Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress , 2011, Nature Cell Biology.

[20]  C. Fan,et al.  The endoplasmic reticulum–associated Hsp40 DNAJB12 and Hsc70 cooperate to facilitate RMA1 E3–dependent degradation of nascent CFTRΔF508 , 2010, Molecular biology of the cell.

[21]  C. Dang,et al.  Targeting mitochondrial glutaminase activity inhibits oncogenic transformation. , 2010, Cancer cell.

[22]  G. Hotamisligil,et al.  Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease , 2010, Cell.

[23]  D. Klionsky,et al.  Regulation mechanisms and signaling pathways of autophagy. , 2009, Annual review of genetics.

[24]  B. Schaffhausen,et al.  Lessons in Signaling and Tumorigenesis from Polyomavirus Middle T Antigen , 2009, Microbiology and Molecular Biology Reviews.

[25]  A. Tee,et al.  Tertiary active transport of amino acids reconstituted by coexpression of System A and L transporters in Xenopus oocytes. , 2009, American Journal of Physiology. Endocrinology and Metabolism.

[26]  J. Toth,et al.  Regulation of Endoplasmic Reticulum-associated Degradation by RNF5-dependent Ubiquitination of JNK-associated Membrane Protein (JAMP)* , 2009, Journal of Biological Chemistry.

[27]  Jeffrey P. MacKeigan,et al.  Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy , 2009, Cell.

[28]  Tsung-Cheng Chang,et al.  c-Myc suppression of miR-23 enhances mitochondrial glutaminase and glutamine metabolism , 2009, Nature.

[29]  Anthony Mancuso,et al.  Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction , 2008, Proceedings of the National Academy of Sciences.

[30]  T. Herbert,et al.  Inhibition of SNAT2 by metabolic acidosis enhances proteolysis in skeletal muscle. , 2008, Journal of the American Society of Nephrology.

[31]  J. Shan,et al.  Despite Increased ATF4 Binding at the C/EBP-ATF Composite Site following Activation of the Unfolded Protein Response, System A Transporter 2 (SNAT2) Transcription Activity Is Repressed in HepG2 Cells* , 2008, Journal of Biological Chemistry.

[32]  Stephen N. Jones,et al.  The ER-Bound RING Finger Protein 5 (RNF5/RMA1) Causes Degenerative Myopathy in Transgenic Mice and Is Deregulated in Inclusion Body Myositis , 2008, PloS one.

[33]  R. Deberardinis,et al.  Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis , 2007, Proceedings of the National Academy of Sciences.

[34]  K. Bromberg,et al.  Increased expression of the E3 ubiquitin ligase RNF5 is associated with decreased survival in breast cancer. , 2007, Cancer research.

[35]  Robert H. Shoemaker,et al.  Nelfinavir, A Lead HIV Protease Inhibitor, Is a Broad-Spectrum, Anticancer Agent that Induces Endoplasmic Reticulum Stress, Autophagy, and Apoptosis In vitro and In vivo , 2007, Clinical Cancer Research.

[36]  R. Finger,et al.  ASCT2 silencing regulates mammalian target-of-rapamycin growth and survival signaling in human hepatoma cells. , 2007, American journal of physiology. Cell physiology.

[37]  P. Walter,et al.  Signal integration in the endoplasmic reticulum unfolded protein response , 2007, Nature Reviews Molecular Cell Biology.

[38]  M. Setou,et al.  Regulation of Amino Acid Transporter ATA2 by Ubiquitin Ligase Nedd4-2* , 2006, Journal of Biological Chemistry.

[39]  F. Urano,et al.  Autophagy Is Activated for Cell Survival after Endoplasmic ReticulumStress , 2006, Molecular and Cellular Biology.

[40]  C. Fan,et al.  Sequential Quality-Control Checkpoints Triage Misfolded Cystic Fibrosis Transmembrane Conductance Regulator , 2006, Cell.

[41]  M. Hatzoglou,et al.  Amino Acid Starvation Induces the SNAT2 Neutral Amino Acid Transporter by a Mechanism That Involves Eukaryotic Initiation Factor 2α Phosphorylation and cap-independent Translation* , 2006, Journal of Biological Chemistry.

[42]  Peng Huang,et al.  Targeting endoplasmic reticulum protein transport: a novel strategy to kill malignant B cells and overcome fludarabine resistance in CLL. , 2006, Blood.

[43]  T. Sommer,et al.  ERAD: the long road to destruction , 2005, Nature Cell Biology.

[44]  D. Turnbull,et al.  Frequency of rare mitochondrial DNA mutations in patients with suspected Leber’s hereditary optic neuropathy , 2003, Journal of Medical Genetics.

[45]  K. Mori,et al.  Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesis. , 2003, Journal of Hepatology.

[46]  D. Witte,et al.  Overexpression of the neutral amino acid transporter ASCT2 in human colorectal adenocarcinoma. , 2002, Anticancer research.

[47]  M. Medina,et al.  Glutamine and cancer. , 2001, The Journal of nutrition.

[48]  J. Supko,et al.  Analysis of brefeldin A and the prodrug breflate in plasma by gas chromatography with mass selective detection. , 1998, Journal of pharmaceutical and biomedical analysis.

[49]  A. Meijer,et al.  Phosphorylation of Ribosomal Protein S6 Is Inhibitory for Autophagy in Isolated Rat Hepatocytes (*) , 1995, The Journal of Biological Chemistry.