Adiponectin fine‐tuning of liver regeneration dynamics revealed through cellular network modelling

Loss of adiponectin delays the initiation of liver regeneration after partial hepatectomy, but later accelerates regeneration. Loss of adiponectin modulates these regeneration kinetics through decreased hepatocyte response to inflammation and increased growth factor bioavailability. Increased adiponectin suppresses liver regeneration through decreased growth factor bioavailability. Our predictive computational model was able to connect these molecular regulatory events to tissue physiology.

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