A kinase-cGAS cascade to synthesize a therapeutic STING activator

[1]  R. Fasan,et al.  Engineered and Artificial Metalloenzymes for Selective C-H Functionalization. , 2021, Current opinion in green and sustainable chemistry.

[2]  David K. Leahy,et al.  Catalytic asymmetric and stereodivergent oligonucleotide synthesis , 2020, Science.

[3]  Andrew M Haidle,et al.  An orally available non-nucleotide STING agonist with antitumor activity , 2020, Science.

[4]  Ge Qu,et al.  The Crucial Role of Methodology Development in Directed Evolution of Selective Enzymes. , 2020, Angewandte Chemie.

[5]  Jongwon Lim,et al.  Novel Applications of Biocatalysis to Stereochemistry Determination of 2′3′-cGAMP Bisphosphorothioate (2′3′-cGSASMP) , 2020, ACS omega.

[6]  James U Bowie,et al.  Synthetic Biochemistry: The Bio-inspired Cell-Free Approach to Commodity Chemical Production. , 2020, Trends in biotechnology.

[7]  Braddock A Sandoval,et al.  Emerging strategies for expanding the toolbox of enzymes in biocatalysis. , 2020, Current opinion in chemical biology.

[8]  Shane T. Grosser,et al.  Design of an in vitro biocatalytic cascade for the manufacture of islatravir , 2019, Science.

[9]  Adrian T. Grzybowski,et al.  Complete biosynthesis of cannabinoids and their unnatural analogues in yeast , 2019, Nature.

[10]  Martin D. Eastgate,et al.  Unlocking P(V): Reagents for chiral phosphorothioate synthesis , 2018, Science.

[11]  Zhijian J. Chen,et al.  DNA-induced liquid phase condensation of cGAS activates innate immune signaling , 2018, Science.

[12]  Joerg H. Schrittwieser,et al.  Artificial Biocatalytic Linear Cascades for Preparation of Organic Molecules. , 2018, Chemical reviews.

[13]  C. Walsh,et al.  Eight Kinetically Stable but Thermodynamically Activated Molecules that Power Cell Metabolism. , 2017, Chemical reviews.

[14]  Frances H Arnold,et al.  Directed Evolution: Bringing New Chemistry to Life , 2017, Angewandte Chemie.

[15]  Frances H Arnold,et al.  Exploiting and engineering hemoproteins for abiological carbene and nitrene transfer reactions. , 2017, Current opinion in biotechnology.

[16]  C. Boularan,et al.  Design, Synthesis, and Biological Evaluation of Novel Cyclic Adenosine-Inosine Monophosphate (cAIMP) Analogs That Activate Stimulator of Interferon Genes (STING). , 2016, Journal of medicinal chemistry.

[17]  T. Mitchison,et al.  Hydrolysis of 2′3′-cGAMP by ENPP1 and design of non-hydrolyzable analogs , 2014, Nature chemical biology.

[18]  Roger A. Jones,et al.  Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA , 2013, Cell.

[19]  Zhijian J. Chen,et al.  Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. , 2013, Molecules and Cells.

[20]  V. Hornung,et al.  cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING , 2013, Nature.

[21]  R. Vance,et al.  The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING. , 2013, Cell reports.

[22]  Roger A. Jones,et al.  Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase , 2013, Cell.

[23]  Zhijian J. Chen,et al.  Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway , 2013, Science.

[24]  Yoshihiro Hayakawa,et al.  STING is a direct innate immune sensor of cyclic-di-GMP , 2011, Nature.

[25]  Roger A. Jones,et al.  One-flask syntheses of c-di-GMP and the [Rp,Rp] and [Rp,Sp] thiophosphate analogues. , 2010, Organic letters.

[26]  John E. Bercaw,et al.  NMR Chemical Shifts of Trace Impurities: Common Laboratory Solvents, Organics, and Gases in Deuterated Solvents Relevant to the Organometallic Chemist , 2010 .

[27]  Hongbin Yan,et al.  Synthesis and immunostimulatory properties of the phosphorothioate analogues of cdiGMP. , 2008, Bioorganic & medicinal chemistry letters.

[28]  F. Studier,et al.  Protein production by auto-induction in high density shaking cultures. , 2005, Protein expression and purification.

[29]  M. Konrad,et al.  Structural Characterization of the Closed Conformation of Mouse Guanylate Kinase* , 2002, The Journal of Biological Chemistry.

[30]  Abraham Nudelman,et al.  NMR Chemical Shifts of Common Laboratory Solvents as Trace Impurities. , 1997, The Journal of organic chemistry.

[31]  G. Schulz,et al.  High‐resolution structures of adenylate kinase from yeast ligated with inhibitor Ap5A, showing the pathway of phosphoryl transfer , 1995, Protein science : a publication of the Protein Society.

[32]  J. Ludwig,et al.  Rapid and Efficient Synthesis of Nucleoside 5′‐O‐(1‐Thiotriphosphates), 5′‐Triphosphates, and 2′,3′‐Cyclophosphorothioates Using 2‐Chloro‐4H‐1,3,2‐benzodioxaphosphorin‐4‐one. , 1989 .

[33]  J. Ludwig,et al.  Rapid and efficient synthesis of nucleoside 5'-0-(1-thiotriphosphates), 5'-triphosphates and 2',3'-cyclophosphorothioates using 2-chloro-4H-1,3,2-benzodioxaphosphorin-4-one , 1989 .

[34]  G. Whitesides,et al.  A PRACTICAL ENZYMIC SYNTHESIS OF (SP)-ADENOSINE 5′-O-(1-THIOTRIPHOSPHATE) ((SP)-ATP-α-S) , 1984 .

[35]  G. Whitesides,et al.  A practical enzymic synthesis of (Sp)-adenosine 5'-O-(1-thiotriphosphate) ((Sp)-ATP-.alpha.-S) , 1984 .

[36]  G. Whitesides,et al.  A convenient synthesis of disodium acetyl phosphate for use in in situ ATP cofactor regeneration , 1983 .

[37]  E. Jaffe,et al.  31P nuclear magnetic resonance spectra of the thiophosphate analogues of adenine nucleotides; effects of pH and Mg2+ binding. , 1978, Biochemistry.

[38]  P. Frey,et al.  Enzymatic and 32P nuclear magnetic resonance study of adenylate kinase-catalyzed stereospecific phosphorylation of adenosine 5'-phosphorothioate. , 1977, The Journal of biological chemistry.

[39]  J. Vasseur,et al.  Solid‐Phase Synthesis of Oligonucleotide 5′‐(α‐P‐Thio)triphosphates and 5′‐(α‐P‐Thio)(β,γ‐methylene)triphosphates , 2015 .

[40]  F. Eckstein.  Nucleoside phosphorothioates. , 1985, Annual review of biochemistry.