Road to precision: recombinase-based targeting technologies for genome engineering.
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Dagmar Wirth | Hansjörg Hauser | Roland Schucht | H. Hauser | D. Wirth | R. Schucht | L. Gama-Norton | P. Riemer | U. Sandhu | Pamela Riemer | Leonor Gama-Norton | Upneet Sandhu | Pamela Riemer
[1] K. Rajewsky,et al. Vagaries of conditional gene targeting , 2007, Nature Immunology.
[2] Adam James Waite,et al. An improved zinc-finger nuclease architecture for highly specific genome editing , 2007, Nature Biotechnology.
[3] W. Wurst,et al. Conditional brain-specific knockdown of MAPK using Cre/loxP regulated RNA interference , 2007, Nucleic acids research.
[4] Yan Li,et al. An efficient and targeted gene integration system for high-level antibody expression. , 2007, Journal of immunological methods.
[5] R. Biamonte,et al. Residual neurotoxicity in ovarian cancer patients in clinical remission after first-line chemotherapy with carboplatin and paclitaxel: The Multicenter Italian Trial in Ovarian cancer (MITO-4) retrospective study , 2006, BMC Cancer.
[6] Fyodor D Urnov,et al. Targeted gene addition into a specified location in the human genome using designed zinc finger nucleases , 2007, Proceedings of the National Academy of Sciences.
[7] M. Gossen,et al. Promoter crosstalk effects on gene expression. , 2007, Journal of molecular biology.
[8] J. Hughes,et al. Manipulating the Mouse Genome to Engineer Precise Functional Syntenic Replacements with Human Sequence , 2007, Cell.
[9] K. Yamamura,et al. Negative selection with the Diphtheria toxin A fragment gene improves frequency of Cre-mediated cassette exchange in ES cells. , 2006, Journal of biochemistry.
[10] D. Roden,et al. Recombinase‐mediated cassette exchange to rapidly and efficiently generate mice with human cardiac sodium channels , 2006, Genesis.
[11] A. Schambach,et al. Gene therapy: X-SCID transgene leukaemogenicity , 2006, Nature.
[12] Dagmar Wirth,et al. A new generation of retroviral producer cells: predictable and stable virus production by Flp-mediated site-specific integration of retroviral vectors. , 2006, Molecular therapy : the journal of the American Society of Gene Therapy.
[13] T. Jensen,et al. φc31 integrase induces chromosomal aberrations in primary human fibroblasts , 2006, Gene Therapy.
[14] G. Wahl,et al. RMCE-ASAP: a gene targeting method for ES and somatic cells to accelerate phenotype analyses , 2006, Nucleic acids research.
[15] M. Carrondo,et al. The use of recombinase mediated cassette exchange in retroviral vector producer cell lines: predictability and efficiency by transgene exchange. , 2006, Journal of biotechnology.
[16] A. Tolstrup,et al. Production of target‐specific recombinant human polyclonal antibodies in mammalian cells , 2006, Biotechnology and bioengineering.
[17] A. Lauwers,et al. Mutant Lrp1 Knock-In Mice Generated by Recombinase-Mediated Cassette Exchange Reveal Differential Importance of the NPXY Motifs in the Intracellular Domain of LRP1 for Normal Fetal Development , 2006, Molecular and Cellular Biology.
[18] Stefan Glaser,et al. Current issues in mouse genome engineering , 2005, Nature Genetics.
[19] C. Collins,et al. A system for precise analysis of transcription-regulating elements of immunoglobulin genes , 2005, BMC biotechnology.
[20] G. Wahl,et al. Reproducible doxycycline-inducible transgene expression at specific loci generated by Cre-recombinase mediated cassette exchange , 2005, Nucleic acids research.
[21] B. Ledermann,et al. Strong and ubiquitous expression of transgenes targeted into the β‐actin locus by Cre/lox cassette replacement , 2005, Genesis.
[22] K. Shearwin,et al. Transcriptional interference--a crash course. , 2005, Trends in genetics : TIG.
[23] Y. Kanegae,et al. Production of viral vectors using recombinase-mediated cassette exchange , 2005, Nucleic acids research.
[24] Jens C. Brüning,et al. Single copy shRNA configuration for ubiquitous gene knockdown in mice , 2005, Nucleic acids research.
[25] Anna B. Osipovich,et al. Post-entrapment genome engineering: first exon size does not affect the expression of fusion transcripts generated by gene entrapment. , 2005, Genome research.
[26] S. Goetze,et al. Performance of Genomic Bordering Elements at Predefined Genomic Loci , 2005, Molecular and Cellular Biology.
[27] A. Ballabio,et al. Tagging genes with cassette-exchange sites , 2005, Nucleic acids research.
[28] H. Niwa,et al. An efficient system to establish multiple embryonic stem cell lines carrying an inducible expression unit , 2005, Nucleic acids research.
[29] Aram Akopian,et al. Site-specific DNA recombinases as instruments for genomic surgery. , 2005, Advances in genetics.
[30] M. Gossen,et al. Stability and homogeneity of transgene expression in isogenic cells , 2005, Journal of Molecular Medicine.
[31] Mark Groudine,et al. Intragenic DNA methylation alters chromatin structure and elongation efficiency in mammalian cells , 2004, Nature Structural &Molecular Biology.
[32] M. Magnuson,et al. Efficient DNA cassette exchange in mouse embryonic stem cells by staggered positive‐negative selection , 2004, Genesis.
[33] A. Nordheim,et al. Elk‐1 knock‐out mice engineered by Flp recombinase‐mediated cassette exchange , 2004, Genesis.
[34] C. Branda,et al. Talking about a revolution: The impact of site-specific recombinases on genetic analyses in mice. , 2004, Developmental cell.
[35] Cameron S. Osborne,et al. LMO2-Associated Clonal T Cell Proliferation in Two Patients after Gene Therapy for SCID-X1 , 2003, Science.
[36] D. Ow,et al. Site-specific cassette exchange and germline transmission with mouse ES cells expressing φC31 integrase , 2003, Nature Biotechnology.
[37] M. Lauth,et al. Stable and efficient cassette exchange under non-selectable conditions by combined use of two site-specific recombinases. , 2002, Nucleic acids research.
[38] T. Shibui,et al. Construction of engineered CHO strains for high-level production of recombinant proteins , 2002, Applied Microbiology and Biotechnology.
[39] K. Yamamura,et al. Site-directed integration of the cre gene mediated by Cre recombinase using a combination of mutant lox sites. , 2002, Nucleic acids research.
[40] P. Khavari,et al. Stable nonviral genetic correction of inherited human skin disease , 2002, Nature Medicine.
[41] A. Kolb. Genome engineering using site-specific recombinases. , 2002, Cloning and stem cells.
[42] David I. K. Martin,et al. Transcriptional Interference by Independently Regulated Genes Occurs in Any Relative Arrangement of the Genes and Is Influenced by Chromosomal Integration Position , 2002, Molecular and Cellular Biology.
[43] Y. He,et al. [The study of a HPRT locus-specific transgenic method based on FLP recombinase mediated cassette exchange]. , 2001, Shi yan sheng wu xue bao.
[44] A. Berns,et al. Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[45] H. Hauser,et al. Evaluation of retroviral vector design in defined chromosomal loci by Flp-mediated cassette replacement. , 2001, Human gene therapy.
[46] W. Miller,et al. Sequences Flanking Hypersensitive Sites of the β-Globin Locus Control Region Are Required for Synergistic Enhancement , 2001, Molecular and Cellular Biology.
[47] A. Kolb. Selection-Marker-Free Modification of the Murine β-Casein Gene Using a lox2722 Site , 2001 .
[48] S. Fiering,et al. Position Effects Are Influenced by the Orientation of a Transgene with Respect to Flanking Chromatin , 2001, Molecular and Cellular Biology.
[49] M. Groudine,et al. Genomic Targeting of Methylated DNA: Influence of Methylation on Transcription, Replication, Chromatin Structure, and Histone Acetylation , 2000, Molecular and Cellular Biology.
[50] S. Morrison,et al. Site-specific and directional gene replacement mediated by Cre recombinase. , 2000, Journal of immunological methods.
[51] F. Morlé,et al. Non-erythroid Genes Inserted on Either Side of Human HS-40 Impair the Activation of Its Natural α-Globin Gene Targets without Being Themselves Preferentially Activated* , 2000, The Journal of Biological Chemistry.
[52] M. Meyer,et al. Characterization of Cre‐mediated cassette exchange after plasmid microinjection in fertilized mouse oocytes , 2000, Genesis.
[53] S. Fiering,et al. Site-specific chromosomal integration in mammalian cells: highly efficient CRE recombinase-mediated cassette exchange. , 1999, Journal of molecular biology.
[54] B. Sauer,et al. Segmental genomic replacement in embryonic stem cells by double lox targeting. , 1999, Nucleic acids research.
[55] D. Scalzo,et al. The Chicken β-Globin 5′HS4 Boundary Element Blocks Enhancer-Mediated Suppression of Silencing , 1999, Molecular and Cellular Biology.
[56] M. Groudine,et al. DNA cassette exchange in ES cells mediated by Flp recombinase: an efficient strategy for repeated modification of tagged loci by marker-free constructs. , 1998, Biochemistry.
[57] E. Bouhassira,et al. Transcriptional behavior of LCR enhancer elements integrated at the same chromosomal locus by recombinase-mediated cassette exchange. , 1997, Blood.
[58] B. Sauer,et al. Segmental genomic replacement by Cre-mediated recombination: genotoxic stress activation of the p53 promoter in single-copy transformants. , 1997, Nucleic acids research.
[59] J. Bode,et al. Double-reciprocal crossover mediated by FLP-recombinase: a concept and an assay. , 1997, Biochemistry.
[60] H. Hauser,et al. On the use of double FLP recognition targets (FRTs) in the LTR of retroviruses for the construction of high producer cell lines. , 1996, Nucleic acids research.
[61] T. Schlake,et al. Use of mutated FLP recognition target (FRT) sites for the exchange of expression cassettes at defined chromosomal loci. , 1994, Biochemistry.
[62] G. Wahl,et al. Recombinase-mediated gene activation and site-specific integration in mammalian cells. , 1991, Science.