HnRNPA2 is a novel histone acetyltransferase that mediates mitochondrial stress-induced nuclear gene expression

[1]  S. Natsugoe,et al.  Disruption of Cytochrome c Oxidase Function Induces Warburg Effect and Metabolic Reprogramming , 2015, Oncogene.

[2]  Begoña Aguado,et al.  Global variability in gene expression and alternative splicing is modulated by mitochondrial content , 2015, Genome research.

[3]  R. Carstens,et al.  Mitochondrial retrograde signaling induces epithelial–mesenchymal transition and generates breast cancer stem cells , 2014, Oncogene.

[4]  Vincent Procaccio,et al.  Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming , 2014, Proceedings of the National Academy of Sciences.

[5]  Ian A Blair,et al.  Akt-dependent metabolic reprogramming regulates tumor cell histone acetylation. , 2014, Cell metabolism.

[6]  B. Sykes,et al.  Rewiring AMPK and mitochondrial retrograde signaling for metabolic control of aging and histone acetylation in respiratory-defective cells. , 2014, Cell reports.

[7]  M. Guha,et al.  Mitochondrial retrograde signaling at the crossroads of tumor bioenergetics, genetics and epigenetics. , 2013, Mitochondrion.

[8]  G. Shadel,et al.  Epigenetic silencing mediates mitochondria stress-induced longevity. , 2013, Cell metabolism.

[9]  Daehee Hwang,et al.  A Systems Approach for Decoding Mitochondrial Retrograde Signaling Pathways , 2013, Science Signaling.

[10]  Jia Hu,et al.  Promoter-associated small double-stranded RNA interacts with heterogeneous nuclear ribonucleoprotein A2/B1 to induce transcriptional activation. , 2012, The Biochemical journal.

[11]  D. Wallace Mitochondria and cancer , 2012, Nature Reviews Cancer.

[12]  A. Rustgi,et al.  Silencing of IkBβ mRNA causes disruption of mitochondrial retrograde signaling and suppression of tumor growth in vivo. , 2012, Carcinogenesis.

[13]  Chao Yang,et al.  Autoacetylation of the MYST Lysine Acetyltransferase MOF Protein* , 2012, The Journal of Biological Chemistry.

[14]  Chao Lu,et al.  Metabolic regulation of epigenetics. , 2012, Cell metabolism.

[15]  J. Santos-Sacchi,et al.  Mitochondrial Stress Engages E2F1 Apoptotic Signaling to Cause Deafness , 2012, Cell.

[16]  Chao Yang,et al.  MYST protein acetyltransferase activity requires active site lysine autoacetylation , 2012, The EMBO journal.

[17]  Laura C. Greaves,et al.  Mitochondrial DNA and disease , 2012, The Journal of pathology.

[18]  S. Suh,et al.  Splicing factor hnRNP A2/B1 regulates tumor suppressor gene splicing and is an oncogenic driver in glioblastoma. , 2011, Cancer Research.

[19]  Jianping Ding,et al.  Regulation of the histone acetyltransferase activity of hMOF via autoacetylation of Lys274 , 2011, Cell Research.

[20]  J. Denu,et al.  Autoacetylation of the Histone Acetyltransferase Rtt109* , 2011, The Journal of Biological Chemistry.

[21]  Sharon Y. R. Dent,et al.  Chromatin “Prepattern” and Histone Modifiers in a Fate Choice for Liver and Pancreas , 2011, Science.

[22]  M. Birnbaum,et al.  Activation of Akt Is Essential for the Propagation of Mitochondrial Respiratory Stress Signaling and Activation of the Transcriptional Coactivator Heterogeneous Ribonucleoprotein A2 , 2010, Molecular biology of the cell.

[23]  T. Kundu,et al.  Nitric oxide-mediated histone hyperacetylation in oral cancer: target for a water-soluble HAT inhibitor, CTK7A. , 2010, Chemistry & biology.

[24]  N. Sondheimer,et al.  Role of calcineurin, hnRNPA2 and Akt in mitochondrial respiratory stress-mediated transcription activation of nuclear gene targets. , 2010, Biochimica et biophysica acta.

[25]  C. Paweletz,et al.  Role of multi-hnRNP nuclear complex in regulation of tumor suppressor ANXA7 in prostate cancer cells , 2010, Oncogene.

[26]  M. Assanah,et al.  HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer , 2010, Nature.

[27]  J. Norman,et al.  hnRNP A2 regulates alternative mRNA splicing of TP53INP2 to control invasive cell migration. , 2009, Cancer research.

[28]  M. Guha,et al.  Heterogeneous nuclear ribonucleoprotein A2 is a common transcriptional coactivator in the nuclear transcription response to mitochondrial respiratory stress. , 2009, Molecular biology of the cell.

[29]  N. Sondheimer,et al.  A Distinctive Physiological Role for IκBβ in the Propagation of Mitochondrial Respiratory Stress Signaling* , 2008, Journal of Biological Chemistry.

[30]  T. Kundu,et al.  Specific inhibition of p300-HAT alters global gene expression and represses HIV replication. , 2007, Chemistry & biology.

[31]  Michael T Ryan,et al.  Mitochondrial-nuclear communications. , 2007, Annual review of biochemistry.

[32]  S. Srinivasan,et al.  Activation of a Novel Calcineurin-mediated Insulin-like Growth Factor-1 Receptor Pathway, Altered Metabolism, and Tumor Cell Invasion in Cells Subjected to Mitochondrial Respiratory Stress* , 2007, Journal of Biological Chemistry.

[33]  Ching-Chow Chen,et al.  Akt Phosphorylation of p300 at Ser-1834 Is Essential for Its Histone Acetyltransferase and Transcriptional Activity , 2005, Molecular and Cellular Biology.

[34]  N. Avadhani,et al.  Mechanism of mitochondrial stress-induced resistance to apoptosis in mitochondrial DNA-depleted C2C12 myocytes , 2005, Cell Death and Differentiation.

[35]  E. Furth,et al.  Telomere Shortening Exposes Functions for the Mouse Werner and Bloom Syndrome Genes , 2004, Molecular and Cellular Biology.

[36]  N. Avadhani,et al.  Mitochondrial signaling: the retrograde response. , 2004, Molecular cell.

[37]  R. Roeder,et al.  Regulation of the p300 HAT domain via a novel activation loop , 2004, Nature Structural &Molecular Biology.

[38]  B. Spiegelman,et al.  Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha. , 2003, Molecular cell.

[39]  S. Dimauro,et al.  Mitochondrial respiratory-chain diseases. , 2003, The New England journal of medicine.

[40]  G. Amuthan,et al.  Mitochondrial stress-induced calcium signaling, phenotypic changes and invasive behavior in human lung carcinoma A549 cells , 2002, Oncogene.

[41]  J. Remacle,et al.  CREB activation induced by mitochondrial dysfunction is a new signaling pathway that impairs cell proliferation , 2002, The EMBO journal.

[42]  G. Amuthan,et al.  Mitochondria‐to‐nucleus stress signaling induces phenotypic changes, tumor progression and cell invasion , 2001, The EMBO journal.

[43]  B. Freedman,et al.  Retrograde Ca2+ signaling in C2C12 skeletal myocytes in response to mitochondrial genetic and metabolic stress: a novel mode of inter‐organelle crosstalk , 1999, The EMBO journal.

[44]  N. Chandel,et al.  Mitochondrial reactive oxygen species trigger hypoxia-induced transcription. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[45]  M. Grunstein Histone acetylation in chromatin structure and transcription , 1997, Nature.

[46]  Andrew J. Bannister,et al.  The CBP co-activator is a histone acetyltransferase , 1996, Nature.

[47]  C. Allis,et al.  Tetrahymena Histone Acetyltransferase A: A Homolog to Yeast Gcn5p Linking Histone Acetylation to Gene Activation , 1996, Cell.

[48]  B. Honig,et al.  Classical electrostatics in biology and chemistry. , 1995, Science.

[49]  W. D. Martin,et al.  Mitochondrial genome instability and ROS enhance intestinal tumorigenesis in APC(Min/+) mice. , 2012, The American journal of pathology.

[50]  D. Hood,et al.  Interactions between ROS and AMP kinase activity in the regulation of PGC-1alpha transcription in skeletal muscle cells. , 2009, American journal of physiology. Cell physiology.

[51]  J. Workman,et al.  The many HATs of transcription coactivators. , 2000, Trends in biochemical sciences.