The induction of synovitis in the normal rabbit with Fab. A possible experimental model of rheumatoid arthritis.

with the pooled Fab solution (0.27 mg/mL) and tested for aggl tion with normal rabbit serums in diltions of 1:2, 1:32, and 1:128. Those senums which did not react significantly more strongly with sensitized than with unstizedR erythrocytes were considered negative for homoreactant. Of 37 rabbits tested, the serum of only 7 reacted negatively prior to use. Homoreactant titers of serial samples of initiay negative serums were measured in the same way, using serial dihltions of rabbit serum, rangg fr undluted to 1:2048.