Recent advances and prospects for lipid-based nanoparticles as drug carriers in the treatment of human retinal diseases.

[1]  A. Milani,et al.  An Overview of Nanoparticle Protein Corona Literature , 2023, Small.

[2]  Pratima Basak,et al.  Preparation of selective organ-targeting (SORT) lipid nanoparticles (LNPs) using multiple technical methods for tissue-specific mRNA delivery , 2022, Nature Protocols.

[3]  R. Ge,et al.  Lipid Nanoparticles as Delivery Vehicles for Inhaled Therapeutics , 2022, Biomedicines.

[4]  Adam G. Berger,et al.  Massively parallel pooled screening reveals genomic determinants of nanoparticle delivery , 2022, Science.

[5]  V. Préat,et al.  Surface Modification of Lipid-Based Nanoparticles. , 2022, ACS nano.

[6]  Chi Zhang,et al.  Modification of Lipid-Based Nanoparticles: An Efficient Delivery System for Nucleic Acid-Based Immunotherapy , 2022, Molecules.

[7]  Xianqun Fan,et al.  Ocular Nanomedicine , 2022, Advanced science.

[8]  M. Tokeshi,et al.  Microfluidic technologies and devices for lipid nanoparticle-based RNA delivery , 2022, Journal of Controlled Release.

[9]  F. Menaa,et al.  Physicochemical Characterizations and Pharmacokinetic Evaluation of Pentazocine Solid Lipid Nanoparticles against Inflammatory Pain Model , 2022, Pharmaceutics.

[10]  Xue Zhu,et al.  Compritol solid lipid nanoparticle formulations enhance the protective effect of betulinic acid derivatives in human Müller cells against oxidative injury. , 2021, Experimental eye research.

[11]  D. Khanna,et al.  A comprehensive review of SARS-CoV-2 vaccines: Pfizer, Moderna & Johnson & Johnson , 2022, Human vaccines & immunotherapeutics.

[12]  S. Rani,et al.  Chitosan-Coated PLGA Nanoparticles Encapsulating Triamcinolone Acetonide as a Potential Candidate for Sustained Ocular Drug Delivery , 2021, Pharmaceutics.

[13]  D. Bokov,et al.  Liposomes: Structure, Biomedical Applications, and Stability Parameters With Emphasis on Cholesterol , 2021, Frontiers in Bioengineering and Biotechnology.

[14]  Joshua A. Jackman,et al.  Lipid Nanoparticle Technology for Delivering Biologically Active Fatty Acids and Monoglycerides , 2021, International journal of molecular sciences.

[15]  Q. Zhou,et al.  Lipid Nanoparticles-From Liposomes to mRNA Vaccine Delivery, a Landscape of Research Diversity and Advancement. , 2021, ACS nano.

[16]  S. Kent,et al.  From influenza to COVID-19: Lipid nanoparticle mRNA vaccines at the frontiers of infectious diseases , 2021, Acta Biomaterialia.

[17]  J. F. Wright,et al.  Challenges Posed by Immune Responses to AAV Vectors: Addressing Root Causes , 2021, Frontiers in Immunology.

[18]  K. Park,et al.  Lipid-Based Nanoparticles in the Clinic and Clinical Trials: From Cancer Nanomedicine to COVID-19 Vaccines , 2021, Vaccines.

[19]  M. Gagliardi,et al.  The Challenges and Strategies of Antisense Oligonucleotide Drug Delivery , 2021, Biomedicines.

[20]  B. Bui,et al.  Targeted Delivery of LM22A-4 by Cubosomes Protects Retinal Ganglion Cells in An Experimental Glaucoma Model. , 2021, Acta biomaterialia.

[21]  Z. Zhou,et al.  Encapsulation state of messenger RNA inside lipid nanoparticles , 2021, Biophysical journal.

[22]  Yue Yang,et al.  CRISPR/Cas: Advances, Limitations, and Applications for Precision Cancer Research , 2021, Frontiers in Medicine.

[23]  Lukas Farbiak,et al.  Membrane destabilizing ionizable phospholipids for organ selective mRNA delivery and CRISPR/Cas gene editing , 2021, Nature Materials.

[24]  P. Decuzzi,et al.  Cytosolic delivery of nucleic acids: The case of ionizable lipid nanoparticles , 2020, Bioengineering & translational medicine.

[25]  Siddharth Patel,et al.  The effects of PEGylation on LNP based mRNA delivery to the eye , 2020, PloS one.

[26]  S. Persano,et al.  Advances in Lipid Nanoparticles for mRNA-Based Cancer Immunotherapy , 2020, Frontiers in Chemistry.

[27]  M. Taipale,et al.  An efficient KRAB domain for CRISPRi applications in human cells , 2020, Nature methods.

[28]  Altar M. Munis.  Gene Therapy Applications of Non-Human Lentiviral Vectors , 2020, Viruses.

[29]  A. Chilkoti,et al.  Recent trends in protein and peptide-based biomaterials for advanced drug delivery , 2020, Advanced Drug Delivery Reviews.

[30]  S. Tsang,et al.  Therapy in Rhodopsin-Mediated Autosomal Dominant Retinitis Pigmentosa. , 2020, Molecular therapy : the journal of the American Society of Gene Therapy.

[31]  A. Silva,et al.  Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology , 2020, Molecules.

[32]  K. Xue,et al.  Antisense oligonucleotide therapeutics in clinical trials for the treatment of inherited retinal diseases , 2020, Expert opinion on investigational drugs.

[33]  Livia S. Carvalho,et al.  Retinal pigment epithelium and age‐related macular degeneration: A review of major disease mechanisms , 2020, Clinical & experimental ophthalmology.

[34]  A. Dhar,et al.  A brief review on solid lipid nanoparticles: part and parcel of contemporary drug delivery systems , 2020, RSC advances.

[35]  Yifei Huang,et al.  Inhibition of retinal neovascularization by VEGF siRNA delivered via bioreducible lipid-like nanoparticles , 2020, Graefe's Archive for Clinical and Experimental Ophthalmology.

[36]  Z. Strezoska,et al.  CRISPR-mediated transcriptional activation with synthetic guide RNA. , 2020, Journal of biotechnology.

[37]  C. Valéry,et al.  Toxicity and cellular uptake of lipid nanoparticles of different structure and composition. , 2020, Journal of colloid and interface science.

[38]  G. Virgili,et al.  Treatment regimens for administration of anti-vascular endothelial growth factor agents for neovascular age-related macular degeneration. , 2020, The Cochrane database of systematic reviews.

[39]  W. Chan,et al.  An analysis of the binding function and structural organization of the protein corona. , 2020, Journal of the American Chemical Society.

[40]  Qiang Cheng,et al.  Selective ORgan Targeting (SORT) nanoparticles for tissue specific mRNA delivery and CRISPR/Cas gene editing , 2020, Nature Nanotechnology.

[41]  P. Campiglia,et al.  Ocular Formulation Based on Palmitoylethanolamide-Loaded Nanostructured Lipid Carriers: Technological and Pharmacological Profile , 2020, Nanomaterials.

[42]  Sanjay K. S. Patel,et al.  One-step hydrothermal synthesis of magnetic rice straw for effective lipase immobilization and its application in esterification reaction. , 2020, Bioresource technology.

[43]  M. Manoharan,et al.  The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs , 2019, Nature Nanotechnology.

[44]  S. M. Taghdisi,et al.  Therapeutic applications of AS1411 aptamer, an update review. , 2019, International journal of biological macromolecules.

[45]  R. Louzada,et al.  In vivo and in vitro toxicity evaluation of liposome-encapsulated sirolimus , 2019, International Journal of Retina and Vitreous.

[46]  Y. Chau,et al.  Investigating impacts of surface charge on intraocular distribution of intravitreal lipid nanoparticles. , 2019, Experimental eye research.

[47]  Krishanu Saha,et al.  A biodegradable nanocapsule delivers a Cas9 ribonucleoprotein complex for in vivo genome editing , 2019, Nature Nanotechnology.

[48]  S. D. De Smedt,et al.  Müller cells as a target for retinal therapy. , 2019, Drug discovery today.

[49]  Y. Chau,et al.  Intravitreal nanoparticles for retinal delivery. , 2019, Drug discovery today.

[50]  N. Farah,et al.  Gold nanoparticles for multimodal high-resolution imaging of transplanted cells for retinal replacement therapy. , 2019, Nanomedicine.

[51]  Gaurav Sahay,et al.  Lipid nanoparticles for delivery of messenger RNA to the back of the eye. , 2019, Journal of controlled release : official journal of the Controlled Release Society.

[52]  Margaret A. Liu.  A Comparison of Plasmid DNA and mRNA as Vaccine Technologies , 2019, Vaccines.

[53]  J. Prados,et al.  Lipid-Based Nanoparticles: Application and Recent Advances in Cancer Treatment , 2019, Nanomaterials.

[54]  M. Dobrovolskaia,et al.  Subchronic and Chronic Toxicity Evaluation of Inorganic Nanoparticles for Delivery Applications. , 2019, Advanced drug delivery reviews.

[55]  E. Duh,et al.  Controlled release of corticosteroid with biodegradable nanoparticles for treating experimental autoimmune uveitis , 2019, Journal of controlled release : official journal of the Controlled Release Society.

[56]  E. Choi,et al.  Plasma and Nanomaterials: Fabrication and Biomedical Applications , 2019, Nanomaterials.

[57]  Elvira N. Chegarnov,et al.  Results at 5 Years After Gene Therapy for RPE65-Deficient Retinal Dystrophy. , 2018, Human gene therapy.

[58]  Xiaoda Yuan,et al.  Topical Drug Delivery to the Posterior Segment of the Eye: Addressing the Challenge of Preclinical to Clinical Translation , 2018, Pharmaceutical Research.

[59]  M. Ávila,et al.  Retinal changes in rabbit after intravitreal injection of sunitinib encapsulated into solid lipid nanoparticles and polymeric nanocapsules. , 2018, Arquivos brasileiros de oftalmologia.

[60]  S. Solomon,et al.  Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis , 2018, The New England journal of medicine.

[61]  J. B. Demb,et al.  Restoration of vision after de novo genesis of rod photoreceptors in mammalian retinas , 2018, Nature.

[62]  Daniel G. Anderson,et al.  Endothelial siRNA delivery in nonhuman primates using ionizable low–molecular weight polymeric nanoparticles , 2018, Science Advances.

[63]  P. Campiglia,et al.  Innovative Nanoparticles Enhance N-Palmitoylethanolamide Intraocular Delivery , 2018, Front. Pharmacol..

[64]  H. Ameri.  Prospect of retinal gene therapy following commercialization of voretigene neparvovec-rzyl for retinal dystrophy mediated by RPE65 mutation , 2018, Journal of current ophthalmology.

[65]  Keerang Park,et al.  Transduction Patterns of Adeno-associated Viral Vectors in a Laser-Induced Choroidal Neovascularization Mouse Model , 2018, Molecular therapy. Methods & clinical development.

[66]  Jia-You Fang,et al.  Lipid-Based Nanoparticles as a Potential Delivery Approach in the Treatment of Rheumatoid Arthritis , 2018, Nanomaterials.

[67]  U. Kompella,et al.  Intravitreal, Subretinal, and Suprachoroidal Injections: Evolution of Microneedles for Drug Delivery. , 2017, Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.

[68]  Yue-Wern Huang,et al.  The Toxicity of Nanoparticles Depends on Multiple Molecular and Physicochemical Mechanisms , 2017, International journal of molecular sciences.

[69]  Luosheng Tang,et al.  Subretinal Injection: A Review on the Novel Route of Therapeutic Delivery for Vitreoretinal Diseases , 2017, Ophthalmic Research.

[70]  W. Strohl,et al.  Adeno-Associated Virus (AAV) as a Vector for Gene Therapy , 2017, BioDrugs.

[71]  Chao Yang,et al.  Adenovirus-mediated gene delivery: Potential applications for gene and cell-based therapies in the new era of personalized medicine , 2017, Genes & diseases.

[72]  Daniel G. Anderson,et al.  An RNA nanoparticle vaccine against Zika virus elicits antibody and CD8+ T cell responses in a mouse model , 2017, Scientific Reports.

[73]  B. Sullenger,et al.  Aptamers as Therapeutics. , 2017, Annual review of pharmacology and toxicology.

[74]  R. Casson,et al.  A review of the mechanisms of cone degeneration in retinitis pigmentosa , 2016, Acta ophthalmologica.

[75]  J. H. Kim,et al.  Nanoparticle-protein complexes mimicking corona formation in ocular environment. , 2016, Biomaterials.

[76]  D. Monti,et al.  Solid lipid nanoparticles as promising tool for intraocular tobramycin delivery: Pharmacokinetic studies on rabbits. , 2016, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[77]  B. Malaekeh-Nikouei,et al.  Solid Lipid Nanoparticles Improve the Diclofenac Availability in Vitreous after Intraocular Injection , 2016, Journal of drug delivery.

[78]  Peng Huang,et al.  Graphene-based nanomaterials for bioimaging. , 2016, Advanced drug delivery reviews.

[79]  J. Flannery,et al.  Wnt Regulates Proliferation and Neurogenic Potential of Müller Glial Cells via a Lin28/let-7 miRNA-Dependent Pathway in Adult Mammalian Retinas. , 2016, Cell reports.

[80]  Man Li,et al.  Induction of HIV-1 gag specific immune responses by cationic micelles mediated delivery of gag mRNA , 2016, Drug delivery.

[81]  M. Agbaga,et al.  Cell-Specific Promoters Enable Lipid-Based Nanoparticles to Deliver Genes to Specific Cells of the Retina In Vivo , 2016, Theranostics.

[82]  J. Bennett,et al.  In vitro and in vivo rescue of aberrant splicing in CEP290-associated LCA by antisense oligonucleotide delivery. , 2016, Human molecular genetics.

[83]  A. Rodríguez-Gascón,et al.  Structural recovery of the retina in a retinoschisin-deficient mouse after gene replacement therapy by solid lipid nanoparticles. , 2016, Biomaterials.

[84]  James J. Collins,et al.  Comparative Analysis of Cas9 Activators Across Multiple Species , 2016, Nature Methods.

[85]  L. Teimoori-Toolabi,et al.  Precise and efficient siRNA design: a key point in competent gene silencing , 2016, Cancer Gene Therapy.

[86]  Shuai Shi,et al.  Fabrication of a Micellar Supramolecular Hydrogel for Ocular Drug Delivery. , 2016, Biomacromolecules.

[87]  Harshita,et al.  Ceramic Nanoparticles: Fabrication Methods and Applications in Drug Delivery. , 2015, Current pharmaceutical design.

[88]  A. Rodríguez-Gascón,et al.  Solid lipid nanoparticle-based vectors intended for the treatment of X-linked juvenile retinoschisis by gene therapy: In vivo approaches in Rs1h-deficient mouse model. , 2015, Journal of controlled release : official journal of the Controlled Release Society.

[89]  H. Valizadeh,et al.  Solid Lipid Nanoparticles and Nanostructured Lipid Carriers: Structure, Preparation and Application. , 2015, Advanced pharmaceutical bulletin.

[90]  Huanqiu Liu,et al.  Evaluation of biocompatibility and toxicity of biodegradable poly (DL-lactic acid) films. , 2015, American journal of translational research.

[91]  Shuai Shi,et al.  Chitosan grafted methoxy poly(ethylene glycol)-poly(ε-caprolactone) nanosuspension for ocular delivery of hydrophobic diclofenac , 2015, Scientific Reports.

[92]  M. Buffelli,et al.  Effective delivery of recombinant proteins to rod photoreceptors via lipid nanovesicles. , 2015, Biochemical and biophysical research communications.

[93]  M. Dirin,et al.  Going beyond the liver: progress and challenges of targeted delivery of siRNA therapeutics. , 2015, Journal of controlled release : official journal of the Controlled Release Society.

[94]  J. A. Halliday,et al.  Lost in transcription: transient errors in information transfer. , 2015, Current opinion in microbiology.

[95]  Tiansen Li.  Leber congenital amaurosis caused by mutations in RPGRIP1. , 2015, Cold Spring Harbor perspectives in medicine.

[96]  D. Lamprou,et al.  Influence of cholesterol on liposome stability and on in vitro drug release , 2015, Drug Delivery and Translational Research.

[97]  Li Tang,et al.  Corticosteroid-loaded biodegradable nanoparticles for prevention of corneal allograft rejection in rats. , 2015, Journal of controlled release : official journal of the Controlled Release Society.

[98]  Chun-Fang Xu,et al.  Clinical evaluation of pazopanib eye drops versus ranibizumab intravitreal injections in subjects with neovascular age-related macular degeneration. , 2015, Ophthalmology.

[99]  E. Tatum.  Molecular Biology, Nucleic Acids, and the Future of Medicine , 2015, Perspectives in biology and medicine.

[100]  P. Cullis,et al.  Development of lipid nanoparticle formulations of siRNA for hepatocyte gene silencing following subcutaneous administration. , 2014, Journal of controlled release : official journal of the Controlled Release Society.

[101]  H. Okada,et al.  Topical drug delivery to retinal pigment epithelium with microfluidizer produced small liposomes. , 2014, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[102]  K. Sakurai,et al.  Hepatocyte-targeting gene delivery using a lipoplex composed of galactose-modified aromatic lipid synthesized with click chemistry. , 2014, Bioorganic & medicinal chemistry.

[103]  Jian-xing Ma,et al.  Nanoparticle-Assisted Targeted Delivery of Eye-Specific Genes to Eyes Significantly Improves the Vision of Blind Mice In Vivo , 2014, Nano letters.

[104]  J. Kasprzak,et al.  Use of the REG1 anticoagulation system in patients with acute coronary syndromes undergoing percutaneous coronary intervention: results from the phase II RADAR-PCI study. , 2014, EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology.

[105]  Daniel G. Anderson,et al.  In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight. , 2014, Nature nanotechnology.

[106]  Samir Mitragotri,et al.  Challenges associated with Penetration of Nanoparticles across Cell and Tissue Barriers: A Review of Current Status and Future Prospects. , 2014, Nano today.

[107]  J. Flannery,et al.  Specific tools for targeting and expression in Müller glial cells , 2014, Molecular therapy. Methods & clinical development.

[108]  A. Jagota,et al.  Binding between DNA and carbon nanotubes strongly depends upon sequence and chirality. , 2014, Langmuir : the ACS journal of surfaces and colloids.

[109]  A. Lambiase,et al.  An update on intravitreal implants in use for eye disorders. , 2014, Drugs of today.

[110]  Bulent Ozpolat,et al.  Liposomal siRNA nanocarriers for cancer therapy. , 2014, Advanced drug delivery reviews.

[111]  A. Díaz-Tahoces,et al.  A novel cationic niosome formulation for gene delivery to the retina. , 2014, Journal of controlled release : official journal of the Controlled Release Society.

[112]  Marcus Ang,et al.  Sustained drug release in nanomedicine: a long-acting nanocarrier-based formulation for glaucoma. , 2014, ACS nano.

[113]  Robert Langer,et al.  Microfluidic platform for combinatorial synthesis and optimization of targeted nanoparticles for cancer therapy. , 2013, ACS nano.

[114]  David A. Scott,et al.  Genome engineering using the CRISPR-Cas9 system , 2013, Nature Protocols.

[115]  K. Falavarjani,et al.  Adverse events and complications associated with intravitreal injection of anti-VEGF agents: a review of literature , 2013, Eye.

[116]  David A Largaespada,et al.  Evaluating risks of insertional mutagenesis by DNA transposons in gene therapy. , 2013, Translational research : the journal of laboratory and clinical medicine.

[117]  T. Weber,et al.  Pre-existing anti-adeno-associated virus antibodies as a challenge in AAV gene therapy. , 2013, Human gene therapy methods.

[118]  Shannon M. Conley,et al.  Comparative Analysis of DNA Nanoparticles and AAVs for Ocular Gene Delivery , 2012, PloS one.

[119]  Javed Ali,et al.  Nanostructured lipid carriers system: Recent advances in drug delivery , 2012, Journal of drug targeting.

[120]  Shannon M. Conley,et al.  DNA nanoparticle-mediated ABCA4 delivery rescues Stargardt dystrophy in mice. , 2012, The Journal of clinical investigation.

[121]  Nouri Nayerossadat,et al.  Viral and nonviral delivery systems for gene delivery , 2012, Advanced biomedical research.

[122]  H. Kaufman,et al.  Ganciclovir Ophthalmic Gel 0.15%: Safety and Efficacy of a New Treatment for Herpes Simplex Keratitis , 2012, Current eye research.

[123]  E. Fernández,et al.  Dextran and protamine-based solid lipid nanoparticles as potential vectors for the treatment of X-linked juvenile retinoschisis. , 2012, Human gene therapy.

[124]  E. Souto,et al.  Nanostructured lipid carriers for triamcinolone acetonide delivery to the posterior segment of the eye. , 2011, Colloids and surfaces. B, Biointerfaces.

[125]  Sanyog Jain,et al.  Solid lipid nanoparticles: an oral bioavailability enhancer vehicle , 2011, Expert opinion on drug delivery.

[126]  R. Masland.  Cell populations of the retina: the Proctor lecture. , 2011, Investigative ophthalmology & visual science.

[127]  S. Seal,et al.  Nanoceria extend photoreceptor cell lifespan in tubby mice by modulation of apoptosis/survival signaling pathways , 2011, Neurobiology of Disease.

[128]  Qiang Zhang,et al.  A lipid nanoparticle system improves siRNA efficacy in RPE cells and a laser-induced murine CNV model. , 2011, Investigative ophthalmology & visual science.

[129]  R. McIvor.  Therapeutic delivery of mRNA: the medium is the message. , 2011, Molecular therapy : the journal of the American Society of Gene Therapy.

[130]  M. Tolentino.  Systemic and ocular safety of intravitreal anti-VEGF therapies for ocular neovascular disease. , 2011, Survey of ophthalmology.

[131]  J. H. Kim,et al.  The inhibition of retinal neovascularization by gold nanoparticles via suppression of VEGFR-2 activation. , 2011, Biomaterials.

[132]  R. Jain,et al.  CXCL12 (SDF1α)-CXCR4/CXCR7 Pathway Inhibition: An Emerging Sensitizer for Anticancer Therapies? , 2011, Clinical Cancer Research.

[133]  R. Guymer,et al.  Perifoveal müller cell depletion in a case of macular telangiectasia type 2. , 2010, Ophthalmology.

[134]  E. Strettoi,et al.  Inhibition of ceramide biosynthesis preserves photoreceptor structure and function in a mouse model of retinitis pigmentosa , 2010, Proceedings of the National Academy of Sciences.

[135]  P. Gain,et al.  The outer limiting membrane (OLM) revisited: clinical implications , 2010, Clinical Ophthalmology (Auckland, N.Z.).

[136]  J. Hecker,et al.  Lipid-mediated delivery of RNA is more efficient than delivery of DNA in non-dividing cells. , 2010, International journal of pharmaceutics.

[137]  K. Csaky,et al.  Safety implications of vascular endothelial growth factor blockade for subjects receiving intravitreal anti-vascular endothelial growth factor therapies. , 2009, American journal of ophthalmology.

[138]  Xiang Gao,et al.  Nonviral Gene Delivery: Principle, Limitations, and Recent Progress , 2009, The AAPS Journal.

[139]  C. Lehr,et al.  PLGA Nanoparticles Stabilized with Cationic Surfactant: Safety Studies and Application in Oral Delivery of Paclitaxel to Treat Chemical-Induced Breast Cancer in Rat , 2009, Pharmaceutical Research.

[140]  Leaf Huang,et al.  Nonviral methods for siRNA delivery. , 2009, Molecular pharmaceutics.

[141]  D. Mcclements,et al.  Effect of surfactant surface coverage on formation of solid lipid nanoparticles (SLN). , 2009, Journal of colloid and interface science.

[142]  B. Malaekeh-Nikouei,et al.  PREPARATION, CHARACTERIZATION, AND IN VIVO EVALUATION OF NANOLIPOSOMES-ENCAPSULATED BEVACIZUMAB (AVASTIN) FOR INTRAVITREAL ADMINISTRATION , 2009, Retina.

[143]  Shannon M. Conley,et al.  Ocular Delivery of Compacted DNA-Nanoparticles Does Not Elicit Toxicity in the Mouse Retina , 2009, PloS one.

[144]  Eric Pridgen,et al.  Factors Affecting the Clearance and Biodistribution of Polymeric Nanoparticles , 2008, Molecular pharmaceutics.

[145]  Robert Langer,et al.  A combinatorial library of lipid-like materials for delivery of RNAi therapeutics , 2008, Nature Biotechnology.

[146]  H. Ulrich,et al.  Development of the anti-VEGF aptamer to a therapeutic agent for clinical ophthalmology , 2007, Clinical ophthalmology.

[147]  A. Bevilacqua,et al.  Effects of high‐pressure homogenization on the survival of Alicyclobacillus acidoterrestris in a laboratory medium , 2007, Letters in applied microbiology.

[148]  F. Kabbinavar,et al.  Arterial thromboembolic events in patients with metastatic carcinoma treated with chemotherapy and bevacizumab. , 2007, Journal of the National Cancer Institute.

[149]  J. Flannery,et al.  Targeted transgene expression in muller glia of normal and diseased retinas using lentiviral vectors. , 2007, Investigative ophthalmology & visual science.

[150]  Shubiao Zhang,et al.  Toxicity of cationic lipids and cationic polymers in gene delivery. , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[151]  G. Arden,et al.  P-Glycoprotein expression in human retinal pigment epithelium cell lines. , 2006, Experimental eye research.

[152]  S. L. Hyatt,et al.  Plasmid size up to 20 kbp does not limit effective in vivo lung gene transfer using compacted DNA nanoparticles , 2006, Gene Therapy.

[153]  H. Fessi,et al.  Influence of the Formulation for Solid Lipid Nanoparticles Prepared with a Membrane Contactor , 2006, Pharmaceutical development and technology.

[154]  H. Fessi,et al.  Preparation of solid lipid nanoparticles using a membrane contactor. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[155]  J. Heyes,et al.  Cationic lipid saturation influences intracellular delivery of encapsulated nucleic acids. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[156]  W. Zimmer,et al.  Nuclear entry of nonviral vectors , 2005, Gene Therapy.

[157]  E. Gragoudas,et al.  Pegaptanib for neovascular age-related macular degeneration. , 2004, The New England journal of medicine.

[158]  Andre K. Geim,et al.  Electric Field Effect in Atomically Thin Carbon Films , 2004, Science.

[159]  Theresa A. Storm,et al.  Comparison of adenoviral and adeno-associated viral vectors for pancreatic gene delivery in vivo. , 2004, Human gene therapy.

[160]  U. Bakowsky,et al.  Preparation and characterization of cationic PLGA nanospheres as DNA carriers. , 2004, Biomaterials.

[161]  M. Rimmele.  Nucleic Acid Aptamers as Tools and Drugs: Recent Developments , 2003, Chembiochem : a European journal of chemical biology.

[162]  Adam Bagg,et al.  Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer. , 2003, Molecular genetics and metabolism.

[163]  M. Trotta,et al.  Preparation of solid lipid nanoparticles by a solvent emulsification-diffusion technique. , 2003, International journal of pharmaceutics.

[164]  Mark A. Kay,et al.  Progress and problems with the use of viral vectors for gene therapy , 2003, Nature Reviews Genetics.

[165]  Sridhar Duvvuri,et al.  Drug delivery to the retina: challenges and opportunities , 2003, Expert opinion on biological therapy.

[166]  P. Rakoczy,et al.  Adenovirus and adeno-associated virus vectors. , 2002, DNA and cell biology.

[167]  R. Müller,et al.  Nanostructured lipid matrices for improved microencapsulation of drugs. , 2002, International journal of pharmaceutics.

[168]  J. Benoit,et al.  A Novel Phase Inversion-Based Process for the Preparation of Lipid Nanocarriers , 2002, Pharmaceutical Research.

[169]  M. Moreno-Aliaga,et al.  Enhanced gene delivery in vitro and in vivo by improved transferrin-lipoplexes. , 2002, Biochimica et biophysica acta.

[170]  Y. Ogura,et al.  Scleral plug of biodegradable polymers containing ganciclovir for experimental cytomegalovirus retinitis. , 2001, Investigative ophthalmology & visual science.

[171]  W. Thoreson,et al.  Expression of Multidrug Resistance-Associated Protein (MRP) in Human Retinal Pigment Epithelial Cells and Its Interaction with BAPSG, a Novel Aldose Reductase Inhibitor , 2001, Pharmaceutical Research.

[172]  K. Mäder,et al.  Solid lipid nanoparticles: production, characterization and applications. , 2001, Advanced drug delivery reviews.

[173]  M. Bally,et al.  Use of poly(ethylene glycol)-lipid conjugates to regulate the surface attributes and transfection activity of lipid-DNA particles. , 2000, Journal of pharmaceutical sciences.

[174]  M E Eldefrawi,et al.  In vitro selection of RNA molecules that displace cocaine from the membrane-bound nicotinic acetylcholine receptor. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[175]  B. Roehr.  Fomivirsen approved for CMV retinitis. , 1998, Journal of the International Association of Physicians in AIDS Care.

[176]  I. Verma,et al.  Gene therapy - promises, problems and prospects , 1997, Nature.

[177]  D. Curiel,et al.  Characterization of a messenger RNA polynucleotide vaccine vector. , 1995, Cancer research.

[178]  G. Lenzen,et al.  Induction of virus‐specific cytotoxic T lymphocytes in vivo by liposome‐entrapped mRNA , 1993, European journal of immunology.

[179]  K. Cornetta,et al.  Gene transfer into humans--immunotherapy of patients with advanced melanoma, using tumor-infiltrating lymphocytes modified by retroviral gene transduction. , 1990, The New England journal of medicine.

[180]  G. Acsadi,et al.  Direct gene transfer into mouse muscle in vivo. , 1990, Science.

[181]  T. McIntosh.  The effect of cholesterol on the structure of phosphatidylcholine bilayers. , 1978, Biochimica et biophysica acta.

[182]  E. Korn,et al.  Single bilayer liposomes prepared without sonication. , 1973, Biochimica et biophysica acta.

[183]  M. Wood,et al.  Antisense oligonucleotides: the next frontier for treatment of neurological disorders , 2018, Nature Reviews Neurology.

[184]  Takashi Nakamura,et al.  Innovative Technologies in Nanomedicines: From Passive Targeting to Active Targeting/From Controlled Pharmacokinetics to Controlled Intracellular Pharmacokinetics. , 2017, Macromolecular bioscience.

[185]  A. Joussen,et al.  [Eye Drops Instead of Intravitreal Injections? The Dream of Treating Macular Diseases by Topically Administered Drugs]. , 2017, Klinische Monatsblätter für Augenheilkunde.

[186]  Francesco Salvatore,et al.  The impact of nanoparticle protein corona on cytotoxicity, immunotoxicity and target drug delivery. , 2016, Nanomedicine.

[187]  V. Préat,et al.  Nanostructured lipid carriers: Promising drug delivery systems for future clinics. , 2016, Nanomedicine : nanotechnology, biology, and medicine.

[188]  Murali Ramamoorth,et al.  Non viral vectors in gene therapy- an overview. , 2015, Journal of clinical and diagnostic research : JCDR.

[189]  Wenzhong Li,et al.  Non-viral gene delivery methods. , 2013, Current pharmaceutical biotechnology.

[190]  R. Tiwari,et al.  Drug delivery systems: An updated review , 2012, International journal of pharmaceutical investigation.

[191]  Zhijian Wu,et al.  Effect of genome size on AAV vector packaging. , 2010, Molecular therapy : the journal of the American Society of Gene Therapy.

[192]  A. Ziady,et al.  Real-time imaging of gene delivery and expression with DNA nanoparticle technologies. , 2009, Methods in molecular biology.

[193]  Robert Blumenthal,et al.  Lipid-based nanoparticles as pharmaceutical drug carriers: from concepts to clinic. , 2009, Critical reviews in therapeutic drug carrier systems.

[194]  M. Schubert,et al.  Solvent injection as a new approach for manufacturing lipid nanoparticles--evaluation of the method and process parameters. , 2003, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[195]  Joan W. Miller,et al.  Controlled delivery of the anti-VEGF aptamer EYE001 with poly(lactic-co-glycolic)acid microspheres. , 2003, Investigative ophthalmology & visual science.

[196]  L. Prescott.  Doxil offers hope to KS sufferers. , 1995, Journal of the International Association of Physicians in AIDS Care.

[197]  A. Bangham,et al.  NEGATIVE STAINING OF PHOSPHOLIPIDS AND THEIR STRUCTURAL MODIFICATION BY SURFACE-ACTIVE AGENTS AS OBSERVED IN THE ELECTRON MICROSCOPE. , 1964, Journal of molecular biology.