GTPase mechanism of Gproteins from the 1.7-Å crystal structure of transducin α - GDP AIF−4

[1]  S. Sprang,et al.  Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis. , 1994, Science.

[2]  P B Sigler,et al.  The 2.2 A crystal structure of transducin-alpha complexed with GTP gamma S. , 1994, Nature.

[3]  A. Warshel,et al.  Why have mutagenesis studies not located the general base in ras p21 , 1994, Nature Structural Biology.

[4]  Heidi E. Hamm,et al.  Structural determinants for activation of the α-subunit of a heterotrimeric G protein , 1994, Nature.

[5]  T. Darden,et al.  Role of glutamine-61 in the hydrolysis of GTP by p21H-ras: an experimental and theoretical study. , 1994, Biochemistry.

[6]  Heidi E. Hamm,et al.  The 2.2 Å crystal structure of transducin-α complexed with GTPγS , 1993, Nature.

[7]  F. McCormick,et al.  Structural requirements for the interaction of p21ras with GAP, exchange factors, and its biological effector target. , 1993, The Journal of biological chemistry.

[8]  B. Sykes,et al.  Formation of the stable myosin-ADP-aluminum fluoride and myosin-ADP-beryllium fluoride complexes and their analysis using 19F NMR. , 1993, The Journal of biological chemistry.

[9]  P. Schultz,et al.  Probing the structure and mechanism of Ras protein with an expanded genetic code. , 1993, Science.

[10]  I. Schlichting,et al.  Studies on the structure and mechanism of H-ras p21. , 1992, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[11]  S. Kim,et al.  X-ray crystal structures of transforming p21 ras mutants suggest a transition-state stabilization mechanism for GTP hydrolysis. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[12]  Z. Pająk,et al.  An X-ray and nuclear magnetic resonance study of structure and ion motions in (C(NH2)3)3AlF6 , 1992 .

[13]  M. Carson RIBBONS 2.0 , 1991 .

[14]  B. Antonny,et al.  GTP hydrolysis mechanisms in ras p21 and in the ras-GAP complex studied by fluorescence measurements on tryptophan mutants. , 1991, Biochemistry.

[15]  B. Caillou,et al.  gsp mutations in human thyroid tumours. , 1991, Oncogene.

[16]  J. Zou,et al.  Improved methods for building protein models in electron density maps and the location of errors in these models. , 1991, Acta crystallographica. Section A, Foundations of crystallography.

[17]  A. Gilman,et al.  19F and 31P NMR spectroscopy of G protein alpha subunits. Mechanism of activation by Al3+ and F-. , 1991, The Journal of biological chemistry.

[18]  W. Kabsch,et al.  Three-dimensional structures of H-ras p21 mutants: Molecular basis for their inability to function as signal switch molecules , 1990, Cell.

[19]  W. Kabsch,et al.  Refined crystal structure of the triphosphate conformation of H‐ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis. , 1990, The EMBO journal.

[20]  A. Wittinghofer,et al.  Inhibition of GTPase activating protein stimulation of Ras-p21 GTPase by the Krev-1 gene product. , 1990, Science.

[21]  J. Issartel,et al.  Direct identification of the fluoroaluminate and fluoroberyllate species responsible for inhibition of the mitochondrial F1‐ATPase , 1989 .

[22]  H. Bourne,et al.  GTPase inhibiting mutations activate the α chain of Gs and stimulate adenylyl cyclase in human pituitary tumours , 1989, Nature.

[23]  F. Westheimer Why nature chose phosphates. , 1987, Science.

[24]  A. Schepartz,et al.  Hydrolysis of an amide in a carboxypeptidase model using cobalt(III) and bifunctional catalysts , 1987 .

[25]  C. Der,et al.  Biological and biochemical properties of human ras H genes mutated at codon 61 , 1986, Cell.

[26]  J. Bigay,et al.  Fluoroaluminates activate transducin‐GDP by mimicking the γ‐phosphate of GTP in its binding site , 1985 .

[27]  A. Gilman,et al.  Aluminum: a requirement for activation of the regulatory component of adenylate cyclase by fluoride. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[28]  C. G. Swain,et al.  Concerted Displacement Reactions. VIII. Polyfunctional Catalysis1 , 1952 .

[29]  D. Lowy,et al.  Function and regulation of ras. , 1993, Annual review of biochemistry.

[30]  L. Stryer,et al.  Transducin and the cyclic GMP phosphodiesterase of retinal rod outer segments. , 1983, Methods in enzymology.