论文信息 - Target accessibility dictates the potency of human RISC

Target accessibility dictates the potency of human RISC

In this report, we examined the effect of increased target site access on activated human RNA-induced silencing complex (RISC*) catalysis. Kinetic studies revealed that siRNA-programmed RISC* cleaved target RNA with higher efficiencies when target site access was increased. These results provide evidence that target site access is linked to RISC* catalysis.

Tariq M Rana | T. Rana | Kirk M Brown | Chia-ying Chu | Chia‐ying Chu

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