Antihyperglycemic mechanism of metformin occurs via the AMPK/LXRα/POMC pathway

[1]  K. Faber,et al.  Metformin Protects Rat Hepatocytes against Bile Acid-Induced Apoptosis , 2013, PloS one.

[2]  E. Liao Management of type 2 diabetes: new and future developments in treatment. , 2012, The American journal of medicine.

[3]  P. Froment,et al.  Metformin Decreases GnRH- and Activin-Induced Gonadotropin Secretion in Rat Pituitary Cells: Potential Involvement of Adenosine 5′ Monophosphate-Activated Protein Kinase (PRKA)1 , 2011, Biology of reproduction.

[4]  José Manuel Fernández-Real,et al.  OCT1 Expression in Adipocytes Could Contribute to Increased Metformin Action in Obese Subjects , 2010, Diabetes.

[5]  B. Gabryel,et al.  Quantification of metformin by the HPLC method in brain regions, cerebrospinal fluid and plasma of rats treated with lipopolysaccharide , 2010, Pharmacological reports : PR.

[6]  Craig I Coleman,et al.  Effect of noninsulin antidiabetic drugs added to metformin therapy on glycemic control, weight gain, and hypoglycemia in type 2 diabetes. , 2010, JAMA.

[7]  D. Wile,et al.  Association of Metformin, Elevated Homocysteine, and Methylmalonic Acid Levels and Clinically Worsened Diabetic Peripheral Neuropathy , 2009, Diabetes Care.

[8]  Sang -Geon Kim,et al.  Role of adenosine monophosphate‐activated protein kinase–p70 ribosomal S6 kinase‐1 pathway in repression of liver X receptor‐alpha–dependent lipogenic gene induction and hepatic steatosis by a novel class of dithiolethiones , 2009, Hepatology.

[9]  E. Rial,et al.  Metformin induces oxidative stress in white adipocytes and raises uncoupling protein 2 levels. , 2008, The Journal of endocrinology.

[10]  G. Barsh,et al.  AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons. , 2007, The Journal of clinical investigation.

[11]  B. Viollet,et al.  Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth. , 2007, Cancer research.

[12]  M. Nishiyama,et al.  Activation of AMP-activated protein kinase stimulates proopiomelanocortin gene transcription in AtT20 corticotroph cells. , 2007, American journal of physiology. Endocrinology and metabolism.

[13]  G. Ronnett,et al.  Developing a head for energy sensing: AMP‐activated protein kinase as a multifunctional metabolic sensor in the brain , 2006, The Journal of physiology.

[14]  G. Arteel,et al.  Metformin prevents alcohol-induced liver injury in the mouse: Critical role of plasminogen activator inhibitor-1. , 2006, Gastroenterology.

[15]  S. Tanumihardjo,et al.  The acute and chronic toxic effects of vitamin A. , 2006, The American journal of clinical nutrition.

[16]  G. Arteel,et al.  Critical Role of Plasminogen Activator Inhibitor-1 in Cholestatic Liver Injury and Fibrosis , 2006, Journal of Pharmacology and Experimental Therapeutics.

[17]  K-U. Lee,et al.  Hypothalamic AMP-activated protein kinase mediates counter-regulatory responses to hypoglycaemia in rats , 2005, Diabetologia.

[18]  W. G. Wiles,et al.  Activation of the AMP-activated Protein Kinase by the Anti-diabetic Drug Metformin in Vivo , 2004, Journal of Biological Chemistry.

[19]  S. Craig,et al.  Betaine in human nutrition. , 2004, The American journal of clinical nutrition.

[20]  R. Ahima,et al.  Adiponectin acts in the brain to decrease body weight , 2004, Nature Medicine.

[21]  C. Lamendola,et al.  Effect of metformin treatment on multiple cardiovascular disease risk factors in patients with type 2 diabetes mellitus. , 2004, Metabolism: clinical and experimental.

[22]  J. Tayek,et al.  Cortisol increases gluconeogenesis in humans: its role in the metabolic syndrome. , 2001, Clinical science.

[23]  Margaret S. Wu,et al.  Role of AMP-activated protein kinase in mechanism of metformin action. , 2001, The Journal of clinical investigation.

[24]  P. Oliveira,et al.  Bile acids affect liver mitochondrial bioenergetics: possible relevance for cholestasis therapy. , 2000, Toxicological sciences : an official journal of the Society of Toxicology.

[25]  P Meneton,et al.  Renal physiology of the mouse. , 2000, American journal of physiology. Renal physiology.

[26]  R. Holman,et al.  Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34) , 1998, The Lancet.

[27]  M. Roy,et al.  Hypothalamic-pituitary-adrenal axis dysregulation among diabetic outpatients , 1990, Psychiatry Research.

[28]  I. Vermes,et al.  INCREASED PLASMA LEVELS OF IMMUNOREACTIVE β-ENDORPHIN AND CORTICOTROPIN IN NON-INSULIN-DEPENDENT DIABETES , 1985, The Lancet.

[29]  D. Steinberg Letter: Scientific medicine. , 1974, Lancet.

[30]  E. Oetjen Management of type 2 diabetes: new and future developments in treatment , 2012 .

[31]  M. Schröder,et al.  Consequences of stress in the secretory pathway: The ER stress response and its role in the metabolic syndrome. , 2010, Methods in molecular biology.

[32]  M. Taouis,et al.  Adiponectin receptors are expressed in hypothalamus and colocalized with proopiomelanocortin and neuropeptide Y in rodent arcuate neurons. , 2009, The Journal of endocrinology.

[33]  M. Mori,et al.  Liver X receptor-alpha regulates proopiomelanocortin (POMC) gene transcription in the pituitary. , 2009, Molecular endocrinology.

[34]  D. Hardie,et al.  AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. , 2005, Cell metabolism.