Towards flow-through/flow injection electronic tongue for the analysis of pharmaceuticals

Abstract The learning process (calibration) of electronic tongue (ET) systems involves the acquisition of a large number of data. The introduction of continuous-flow methods, including flow-through and flow injection analysis, can significantly streamline and simplify the calibration process. However, the performance characteristics of the sensors based on the same receptor layers differ in various modes of measurements. In this work, the performances of the potentiometric sensors working in various sensor array configurations i.e. classical, batch set-up, flow-through set-up and flow injection analysis (FIA) set-up were determined. Moreover, the classification capabilities of the designed ET systems were compared on the basis of the differentiation between pharmaceutical samples of pure Ibuprofen and Ibuprofen modified with various co-spray dried excipients.

[1]  Luiz H. C. Mattoso,et al.  Modification of electrospun nylon nanofibers using layer-by-layer films for application in flow injection electronic tongue: Detection of paraoxon pesticide in corn crop , 2012 .

[2]  S. Buratti,et al.  Characterization and classification of Italian Barbera wines by using an electronic nose and an amperometric electronic tongue , 2004 .

[3]  Peter Kleinebudde,et al.  Taste sensing systems (electronic tongues) for pharmaceutical applications. , 2011, International journal of pharmaceutics.

[4]  S. Humphrey,et al.  A review of saliva: normal composition, flow, and function. , 2001, The Journal of prosthetic dentistry.

[5]  Patrycja Ciosek,et al.  Sensor arrays for liquid sensing--electronic tongue systems. , 2007, The Analyst.

[6]  Zbigniew Brzózka,et al.  Analysis of dialysate fluids with the use of a potentiometric electronic tongue , 2008 .

[7]  Carolin Eckert,et al.  Taste evaluation of multicomponent mixtures using a human taste panel, electronic taste sensing systems and HPLC , 2013 .

[8]  M. Zaborowski,et al.  Monitoring of beer fermentation based on hybrid electronic tongue. , 2012, Bioelectrochemistry.

[9]  Alisa Rudnitskaya,et al.  Electronic tongue for pharmaceutical analytics: quantification of tastes and masking effects , 2004, Analytical and bioanalytical chemistry.

[10]  Dmitry Kirsanov,et al.  Assessment of bitter taste of pharmaceuticals with multisensor system employing 3 way PLS regression. , 2013, Analytica chimica acta.

[11]  J. Marty,et al.  Automated resolution of dichlorvos and methylparaoxon pesticide mixtures employing a Flow Injection system with an inhibition electronic tongue. , 2009, Biosensors & bioelectronics.

[12]  Patrycja Ciosek,et al.  Flow-through sensor array applied to cytotoxicity assessment in cell cultures for drug-testing purposes. , 2014, Biosensors & bioelectronics.

[13]  S. Benedetti,et al.  Amperometric Electronic Tongue for the Evaluation of the Tea Astringency , 2006 .

[14]  M. Valle.  Electronic Tongues Employing Electrochemical Sensors , 2010 .

[15]  Montserrat Cortina,et al.  Automated electronic tongue based on potentiometric sensors for the determination of a trinary anionic surfactant mixture. , 2008, Journal of pharmaceutical and biomedical analysis.

[16]  A. Bratov,et al.  Recent trends in potentiometric sensor arrays--a review. , 2010, Analytica chimica acta.

[17]  E. Romanowska,et al.  Effect of lead accumulation in maize leaves on their chemical images created by a flow-through electronic tongue. , 2013, Talanta.

[18]  Patrycja Ciosek,et al.  Electronic tongue for the detection of taste-masking microencapsulation of active pharmaceutical substances. , 2010, Bioelectrochemistry.

[19]  S. Alegret,et al.  Sequential injection system with higher dimensional electrochemical sensor signals Part 1. Voltammetric e-tongue for the determination of oxidizable compounds. , 2005, Talanta.

[20]  F. Winquist,et al.  A flow injection voltammetric electronic tongue applied to paper mill industrial waters , 2006 .

[21]  I. Lundström,et al.  Flow injection analysis applied to a voltammetric electronic tongue , 2002 .

[22]  A. Zamojska,et al.  Monitoring of periodic anaerobic digestion with flow-through array of miniaturized ion-selective electrodes. , 2010, Bioelectrochemistry.

[23]  Patrycja Ciosek,et al.  Evaluation of organoleptic and texture properties of dried apples by hybrid electronic tongue , 2013 .

[24]  C. Domínguez,et al.  Integrated multisensor chip with sequential injection technique as a base for “electronic tongue” devices , 2008 .

[25]  Patrycja Ciosek,et al.  Potentiometric Electronic Tongues for Foodstuff and Biosample Recognition—An Overview , 2011, Sensors.

[26]  Zbigniew Brzozka,et al.  Electronic tongue for flow-through analysis of beverages , 2006 .

[27]  Cecilia Jiménez-Jorquera,et al.  Electronic integrated multisensor tongue applied to grape juice and wine analysis. , 2008, The Analyst.

[28]  Salvador Alegret,et al.  Application of a potentiometric electronic tongue as a classification tool in food analysis. , 2005, Talanta.

[29]  Antonio Riul,et al.  Recent advances in electronic tongues. , 2010, The Analyst.

[30]  L. Opalski,et al.  SIA system employing the transient response from a potentiometric sensor array--Correction of a saline matrix effect. , 2010, Talanta.

[31]  P. Ciosek,et al.  The recognition of beer with flow-through sensor array based on miniaturized solid-state electrodes. , 2006, Talanta.

[32]  M. del Valle,et al.  Electronic tongues in flow analysis. , 2007, Analytica chimica acta.

[33]  Patrycja Ciosek,et al.  Performance of selective and partially selective sensors in the recognition of beverages. , 2007, Talanta.

[34]  D. Barends,et al.  Biowaiver monographs for immediate release solid oral dosage forms: ibuprofen. , 2005, Journal of pharmaceutical sciences.

[35]  H. Nam,et al.  All-solid-state electronic tongue and its application for beverage analysis , 2002 .

[36]  Davide Ballabio,et al.  Prediction of Italian red wine sensorial descriptors from electronic nose, electronic tongue and spectrophotometric measurements by means of Genetic Algorithm regression models , 2007 .

[37]  M. Valle,et al.  Resolution of amino acid mixtures by an array of potentiometric sensors based on boronic acid derivative in a SIA flow system , 2013 .

[38]  D. Barends,et al.  Biowaiver monographs for immediate release solid oral dosage forms: isoniazid. , 2007, Journal of pharmaceutical sciences.

[39]  A. Zamojska,et al.  The monitoring of methane fermentation in sequencing batch bioreactor with flow-through array of miniaturized solid state electrodes. , 2010, Talanta.