Ionizable Amino‐Polyesters Synthesized via Ring Opening Polymerization of Tertiary Amino‐Alcohols for Tissue Selective mRNA Delivery
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Robert Langer | Daniel G Anderson | Piotr S Kowalski | Daniel G. Anderson | R. Langer | Piotr S. Kowalski | A. Rudra | Yuxuan Huang | Yuxuan Huang | Arnab Rudra | Umberto Capasso Palmiero | Umberto Capasso Palmiero | Arnab Rudra
[1] Daniel G. Anderson,et al. Poly(β‐amino ester)‐co‐poly(caprolactone) Terpolymers as Nonviral Vectors for mRNA Delivery In Vitro and In Vivo , 2018, Advanced healthcare materials.
[2] Robert Langer,et al. Rapid, Single-Cell Analysis and Discovery of Vectored mRNA Transfection In Vivo with a loxP-Flanked tdTomato Reporter Mouse , 2017, Molecular therapy. Nucleic acids.
[3] Qiang Cheng,et al. Systemic mRNA Delivery to the Lungs by Functional Polyester-based Carriers. , 2017, Biomacromolecules.
[4] Daniel G. Anderson,et al. Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing , 2017, Nature Biotechnology.
[5] Jong-Min Lim,et al. Mechanistic understanding of in vivo protein corona formation on polymeric nanoparticles and impact on pharmacokinetics , 2017, Nature Communications.
[6] K. Kataoka,et al. Virus‐Mimicking Chimaeric Polymersomes Boost Targeted Cancer siRNA Therapy In Vivo , 2017, Advanced materials.
[7] Gaurav Sahay,et al. Boosting Intracellular Delivery of Lipid Nanoparticle-Encapsulated mRNA. , 2017, Nano letters.
[8] Robert Langer,et al. Nanoparticle-based drug delivery systems: a commercial and regulatory outlook as the field matures , 2017, Expert opinion on drug delivery.
[9] Özlem Türeci,et al. Elimination of large tumors in mice by mRNA-encoded bispecific antibodies , 2017, Nature Medicine.
[10] Daniel G. Anderson,et al. Advances in the delivery of RNA therapeutics: from concept to clinical reality , 2017, Genome Medicine.
[11] C. Villa,et al. Mechanisms that determine nanocarrier targeting to healthy versus inflamed lung regions. , 2017, Nanomedicine : nanotechnology, biology, and medicine.
[12] D. Weissman,et al. Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge , 2017, Nature Communications.
[13] I. Verma,et al. Systemic delivery of factor IX messenger RNA for protein replacement therapy , 2017, Proceedings of the National Academy of Sciences.
[14] Daniel G. Anderson,et al. Materials for non-viral intracellular delivery of messenger RNA therapeutics. , 2016, Journal of controlled release : official journal of the Controlled Release Society.
[15] Jing Hao,et al. Progress towards the Synthesis of Amino Polyesters via Ring-Opening Polymerization (ROP) of Functional Lactones , 2016 .
[16] Daniel G Anderson,et al. Polymer-Lipid Nanoparticles for Systemic Delivery of mRNA to the Lungs. , 2016, Angewandte Chemie.
[17] Daniel G. Anderson,et al. Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, and Toxoplasma gondii challenges with a single dose , 2016, Proceedings of the National Academy of Sciences.
[18] Özlem Türeci,et al. Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy , 2016, Nature.
[19] Kevin J. Kauffman,et al. Therapeutic efficacy in a hemophilia B model using a biosynthetic mRNA liver depot system , 2016, Gene Therapy.
[20] Gaurav Sahay,et al. Challenges in carrier-mediated intracellular delivery: moving beyond endosomal barriers. , 2016, Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology.
[21] O. Farokhzad,et al. Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release. , 2016, Chemical reviews.
[22] P. Levkin,et al. Combinatorial Approach to Nanoarchitectonics for Nonviral Delivery of Nucleic Acids , 2016, Advanced materials.
[23] Daniel G. Anderson,et al. Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo , 2016, Nature Biotechnology.
[24] H. Fuchs,et al. Clinical Chemistry Reference Intervals for C57BL/6J, C57BL/6N, and C3HeB/FeJ Mice (Mus musculus). , 2016, Journal of the American Association for Laboratory Animal Science : JAALAS.
[25] Daniel G. Anderson,et al. Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs. , 2015, Nano letters.
[26] Yunfeng Yan,et al. Rapid Synthesis of a Lipocationic Polyester Library via Ring-Opening Polymerization of Functional Valerolactones for Efficacious siRNA Delivery. , 2015, Journal of the American Chemical Society.
[27] T. Schlake,et al. Sequence-engineered mRNA Without Chemical Nucleoside Modifications Enables an Effective Protein Therapy in Large Animals , 2015, Molecular therapy : the journal of the American Society of Gene Therapy.
[28] S. Beer-Hammer,et al. In vivo genome editing using nuclease-encoding mRNA corrects SP-B deficiency , 2015, Nature Biotechnology.
[29] Daniel G. Anderson,et al. Ionizable amphiphilic dendrimer-based nanomaterials with alkyl-chain-substituted amines for tunable siRNA delivery to the liver endothelium in vivo. , 2014, Angewandte Chemie.
[30] M. Slevin,et al. ENDOTHELIAL DYSFUNCTION AND INFLAMMATION , 2014 .
[31] J. Kamps,et al. A critical role for Egr-1 during vascular remodelling in pulmonary arterial hypertension. , 2014, Cardiovascular research.
[32] Daniel G. Anderson,et al. Non-viral vectors for gene-based therapy , 2014, Nature Reviews Genetics.
[33] R. Waymouth,et al. Organocatalytic ring-opening polymerization of morpholinones: new strategies to functionalized polyesters. , 2014, Journal of the American Chemical Society.
[34] Robert Langer,et al. Degradable Lipid Nanoparticles with Predictable In Vivo siRNA Delivery Activity , 2014, Nature Communications.
[35] Daniel G. Anderson,et al. In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight. , 2014, Nature nanotechnology.
[36] Jon Christensen,et al. Differential uptake of nanoparticles by endothelial cells through polyelectrolytes with affinity for caveolae , 2014, Proceedings of the National Academy of Sciences.
[37] Akin Akinc,et al. Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles , 2013, Molecular therapy. Nucleic acids.
[38] I. Zuhorn,et al. Mechanism of polyplex- and lipoplex-mediated delivery of nucleic acids: real-time visualization of transient membrane destabilization without endosomal lysis. , 2013, ACS nano.
[39] Z. Rehman,et al. How cationic lipids transfer nucleic acids into cells and across cellular membranes: recent advances. , 2013, Journal of controlled release : official journal of the Controlled Release Society.
[40] P. Cullis,et al. Liposomal drug delivery systems: from concept to clinical applications. , 2013, Advanced drug delivery reviews.
[41] Daniel G. Anderson,et al. Effect of molecular weight of amine end-modified poly(β-amino ester)s on gene delivery efficiency and toxicity. , 2012, Biomaterials.
[42] A. Dudley. Tumor endothelial cells. , 2012, Cold Spring Harbor perspectives in medicine.
[43] Xiabin Jing,et al. Biodegradable synthetic polymers: Preparation, functionalization and biomedical application , 2012 .
[44] J. Kamps,et al. Targeted siRNA delivery to diseased microvascular endothelial cells—Cellular and molecular concepts , 2011, IUBMB life.
[45] J. Rosenecker,et al. Expression of therapeutic proteins after delivery of chemically modified mRNA in mice , 2011, Nature Biotechnology.
[46] Zhaozhong Jiang,et al. Biodegradable poly(amine-co-ester) terpolymers for targeted gene delivery. , 2011, Nature materials.
[47] M. Taljaard,et al. Rationale and design of Enhanced Angiogenic Cell Therapy in Acute Myocardial Infarction (ENACT-AMI): the first randomized placebo-controlled trial of enhanced progenitor cell therapy for acute myocardial infarction. , 2010, American heart journal.
[48] G. Molema. Heterogeneity in responses of microvascular endothelial cells during inflammation , 2010 .
[49] K. G. Rajeev,et al. Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms. , 2010, Molecular therapy : the journal of the American Society of Gene Therapy.
[50] Kenneth J. Longmuir,et al. Cellular organization of normal mouse liver: a histological, quantitative immunocytochemical, and fine structural analysis , 2009, Histochemistry and Cell Biology.
[51] Philippe Lecomte,et al. Recent advances in the synthesis of aliphatic polyesters by ring-opening polymerization. , 2008, Advanced drug delivery reviews.
[52] Robert Langer,et al. A combinatorial polymer library approach yields insight into nonviral gene delivery. , 2008, Accounts of chemical research.
[53] S. Akhtar,et al. Toxicogenomics of non-viral drug delivery systems for RNAi: potential impact on siRNA-mediated gene silencing activity and specificity. , 2007, Advanced drug delivery reviews.
[54] I. Zuhorn,et al. Gene delivery by cationic lipids: in and out of an endosome. , 2007, Biochemical Society transactions.
[55] Shubiao Zhang,et al. Toxicity of cationic lipids and cationic polymers in gene delivery. , 2006, Journal of controlled release : official journal of the Controlled Release Society.
[56] Daniel W. Pack,et al. Design and development of polymers for gene delivery , 2005, Nature Reviews Drug Discovery.
[57] A. Hochberg,et al. Regulatory sequences of H19 and IGF2 genes in DNA‐based therapy of colorectal rat liver metastases , 2005 .
[58] R. Budhiraja,et al. Endothelial Dysfunction in Pulmonary Hypertension , 2004, Circulation.
[59] M. Conese,et al. Biodistribution and transgene expression with nonviral cationic vector/DNA complexes in the lungs , 2000, Gene Therapy.
[60] K. Shakesheff,et al. Polymeric systems for controlled drug release. , 1999, Chemical reviews.