Anion cascade reactions III: Synthesis of 3-isoquinuclidone bridged polycyclic lactams

[1]  Alexandre Audic,et al.  Synthesis of the CDF Ring System of Hexacyclinic Acid , 2022, Synthesis.

[2]  Ming‐Hua Zeng,et al.  CuBr-promoted domino Biginelli reaction for the diastereoselective synthesis of bridged polyheterocycles: mechanism studies and in vitro anti-tumor activities , 2022, Chinese Chemical Letters.

[3]  Xiongwei Jiang,et al.  Iron-catalyzed hydroaminocarbonylation of alkynes: Selective and efficient synthesis of primary α,β-unsaturated amides , 2022, Chinese Chemical Letters.

[4]  Hanmin Huang,et al.  Palladium-Catalyzed Tandem Hydrocarbonylative Lactamization and Cycloaddition Reaction for the Construction of Bridged Polycyclic Lactams. , 2021, Organic letters.

[5]  Youyoung Kim,et al.  Biopatterned Reorganization of Alkaloids Enabled by Ring-Opening Functionalization of Tertiary Amines. , 2021, Journal of the American Chemical Society.

[6]  Wei Chen,et al.  High-Temperature Switchable Nonlinear Optical and Dielectric Material Revealed by Molecular Modification , 2021 .

[7]  Jun Jiang,et al.  Electrosynthesis of 1-indanones , 2021 .

[8]  Ying-Wu Lin,et al.  Visible-light-initiated tandem synthesis of difluoromethylated oxindoles in 2-MeTHF under additive-, metal catalyst-, external photosensitizer-free and mild conditions , 2021, Chinese Chemical Letters.

[9]  Guisheng Zhang,et al.  Nickel-catalyzed deaminative Sonogashira coupling of alkylpyridinium salts enabled by NN2 pincer ligand , 2020, Nature Communications.

[10]  Wei Wei,et al.  Catalyst- and additive-free selective sulfonylation/cyclization of 1,6-enynes with arylazo sulfones leading to sulfonylated γ-butyrolactams , 2020 .

[11]  Shasha Zhang,et al.  Modular Synthesis of Drimane Meroterpenoids Leveraging Decarboxylative Borylation and Suzuki Coupling. , 2020, Organic letters.

[12]  Gang Zhao,et al.  Organophosphine bearing multiple hydrogen-bond donors for asymmetric Michael addition reaction of 1-oxoindane-2-carboxylic acid ester via dual-reagent catalysis , 2020 .

[13]  Gong Chen,et al.  Selective Removal of Aminoquinoline Auxiliary by IBX Oxidation. , 2019, The Journal of organic chemistry.

[14]  X. Liu,et al.  Discovery of ( E)- N1-(3-Fluorophenyl)- N3-(3-(2-(pyridin-2-yl)vinyl)-1 H-indazol-6-yl)malonamide (CHMFL-KIT-033) as a Novel c-KIT T670I Mutant Selective Kinase Inhibitor for Gastrointestinal Stromal Tumors (GISTs). , 2019, Journal of medicinal chemistry.

[15]  Sunkyu Han,et al.  Biosynthetically Inspired Transformation of Iboga to Monomeric Post-iboga Alkaloids , 2019, Chem.

[16]  Xin Hong,et al.  Computational studies of cinchona alkaloid-catalyzed asymmetric Michael additions , 2018, Chinese Chemical Letters.

[17]  Haifeng Yu,et al.  Copper-Catalysed (Diacetoxyiodo)benzene-Promoted Aerobic Esterification Reaction: Synthesis of Oxamates from Acetoacetamides , 2018, Advanced Synthesis & Catalysis.

[18]  C. So,et al.  Palladium-Catalyzed Direct Arylation of Polyfluoroarenes for Accessing Tetra- ortho-Substituted Biaryls: Buchwald-type Ligand Having Complementary -PPh2 Moiety Exhibits Better Efficiency. , 2018, The Journal of organic chemistry.

[19]  K. Mineev,et al.  DNA sequence-specific ligands. XVII. Synthesis, spectral properties, virological and biochemical studies of fluorescent dimeric bisbenzimidazoles DBA(n). , 2018, Bioorganic & medicinal chemistry.

[20]  Yameng Wan,et al.  Selective Cleavage of Inert Aryl C-N Bonds in N-Aryl Amides. , 2018, The Journal of organic chemistry.

[21]  David R. Spring,et al.  A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066 , 2017, Bioorganic & medicinal chemistry.

[22]  Yi‐Xia Jia,et al.  Enantioselective Dearomative Difunctionalization of Indoles by Palladium-Catalyzed Heck/Sonogashira Sequence. , 2017, Angewandte Chemie.

[23]  Y. Lian,et al.  Construction of 1-Heteroaryl-3-azabicyclo[3.1.0]hexanes by sp3-sp2 Suzuki-Miyaura and Chan-Evans-Lam Coupling Reactions of Tertiary Trifluoroborates. , 2017, Organic letters.

[24]  Yong Zhang,et al.  Bio-Catalytic Bis-Michael Reaction for Generating Cyclohexanones with a Quaternary Carbon Center Using Glucoamylase , 2017, Catalysis Letters.

[25]  Guigen Li,et al.  High-Valent Palladium-Promoted Formal Wagner-Meerwein Rearrangement. , 2016, Organic letters.

[26]  G. Posner,et al.  Highly regiocontrolled and stereocontrolled syntheses of polysubstituted aminocyclohexanes: mild inverse-electron-demand Diels–Alder cycloadditions of electrophilic 2-pyridones , 2016 .

[27]  D. Boger,et al.  Synthesis of a Potent Vinblastine: Rationally Designed Added Benign Complexity. , 2016, Journal of the American Chemical Society.

[28]  Xingang Xie,et al.  Bioinspired Collective Syntheses of Iboga-Type Indole Alkaloids. , 2016, Organic letters.

[29]  A. Rahman,et al.  A concise synthesis and evaluation of new malonamide derivatives as potential α-glucosidase inhibitors. , 2016, Bioorganic & medicinal chemistry.

[30]  J. Bajorath,et al.  Limiting the Number of Potential Binding Modes by Introducing Symmetry into Ligands: Structure-Based Design of Inhibitors for Trypsin-Like Serine Proteases. , 2016, Chemistry.

[31]  Xianxiu Xu,et al.  Diastereoselective Synthesis of 3,4-Benzomorphan Derivatives via Tandem [5 + 1]/Hemiaminalization of (2-Aminoaryl)divinyl Ketones. , 2016, Organic letters.

[32]  E. V. D. Eycken,et al.  Regio‐ and Chemoselective Formation of Spiroindolinone–Isoindolinone by a Palladium‐Catalyzed Buchwald–Hartwig Addition–Elimination Sequence , 2014 .

[33]  E. V. Van der Eycken,et al.  Facile access to functionalized spiro[indoline-3,2'-pyrrole]-2,5'-diones via post-Ugi domino Buchwald-Hartwig/Michael reaction. , 2014, Organic letters.

[34]  J. Khurana,et al.  An efficient catalyst free synthesis of nitrogen containing spiro heterocycles via [5 + 1] double Michael addition reaction , 2014 .

[35]  C. Johannes,et al.  Expedient synthesis of bicyclo[3.2.1]octanes and bicyclo[3.3.1]nonanes via the double Michael addition to cyclic dienones , 2013 .

[36]  J. Aubé,et al.  Chemistry of bridged lactams and related heterocycles. , 2013, Chemical reviews.

[37]  Manuela Weber,et al.  Catalytic asymmetric synthesis of spirocyclic azlactones by a double Michael-addition approach. , 2013, Chemistry.

[38]  P. Slepukhin,et al.  Synthesis of 6-Acetyl-1-methyl-3-oxo-5,8-diphenyl-2-azabicyclo[2.2.2]octane-4-carbonitrile , 2013, Chemistry of Heterocyclic Compounds.

[39]  S. Ji,et al.  Palladium-catalyzed carbonylative Sonogashira coupling of aryl bromides via tert-butyl isocyanide insertion. , 2013, The Journal of organic chemistry.

[40]  C. Nájera,et al.  Recent advances in Sonogashira reactions. , 2011, Chemical Society reviews.

[41]  Fu‐She Han,et al.  A Highly Practical and Reliable Nickel Catalyst for Suzuki–Miyaura Coupling of Aryl Halides , 2011 .

[42]  M. Yan,et al.  Organocatalytic conjugate addition of malononitrile to conformationally restricted dienones. , 2011, The Journal of organic chemistry.

[43]  Bin Wu,et al.  Efficient synthesis of optically active 4-nitro-cyclohexanones via bifunctional thiourea-base catalyzed double-Michael addition of nitromethane to dienones. , 2011, Chemical communications.

[44]  J. Cuthbertson,et al.  A Tandem Amination/LactamisationRoute to 2-Azabicyclo[2.2.2]octanones , 2010 .

[45]  Dawei Zhang,et al.  Direct Stereoselective Synthesisof 1-Amino-2,5-diarylcyclohexanecarboxylic Acid Derivatives Basedon a [5+1] Annulation of Divinyl Ketoneand Isocyanoacetate , 2010 .

[46]  A. Macleod,et al.  Identification of potent and selective VEGFR receptor tyrosine kinase inhibitors having new amide isostere headgroups. , 2010, Bioorganic & medicinal chemistry letters.

[47]  T. Nakano,et al.  Design, synthesis, and biological activity of boronic acid-based histone deacetylase inhibitors. , 2009, Journal of medicinal chemistry.

[48]  Qun Liu,et al.  Tandem double-Michael-addition/cyclization/acyl migration of 1,4-dien-3-ones and ethyl isocyanoacetate: stereoselective synthesis of pyrrolizidines. , 2009, Angewandte Chemie.

[49]  J. Aubé,et al.  Stability of medium-bridged twisted amides in aqueous solutions. , 2009, The Journal of organic chemistry.

[50]  Y. V. Reddy,et al.  Double cascade reactions based on the Barbas dienamine platform: highly stereoselective synthesis of functionalized cyclohexanes for cardiovascular agents. , 2008, Organic & biomolecular chemistry.

[51]  Jeffrey L. Cross,et al.  Concise construction of novel bridged bicyclic lactams by sequenced Ugi/RCM/Heck reactions. , 2007, Organic letters.

[52]  Guido Galley,et al.  Novel orally active, dibenzazepinone-based γ-secretase inhibitors , 2007 .

[53]  M. Pudlo,et al.  First Suzuki-Miyaura type cross-coupling of ortho-azidobromobenzene with arylboronic acids and its application to the synthesis of fused aromatic indole-heterocycles , 2007 .

[54]  A. Khorshidi,et al.  RuIII-catalyzed double-conjugate 1,4-addition of indoles to symmetric enones , 2007 .

[55]  C. Nájera,et al.  The Sonogashira reaction: a booming methodology in synthetic organic chemistry. , 2007, Chemical reviews.

[56]  J. Clayden,et al.  The twisted amide 2-quinuclidone: 60 years in the making. , 2006, Angewandte Chemie.

[57]  C. Cativiela,et al.  Efficient synthesis of a new pipecolic acid analogue with a bicyclic structure , 2006 .

[58]  Ji-tai Li,et al.  Synthesis of 1,1-disubstituted-2,6-diarylcyclohexane-4-ones catalyzed by KF/basic Al2O3 under ultrasound. , 2005, Ultrasonics sonochemistry.

[59]  M. O. Khan,et al.  Solution-Phase Parallel Synthesis of N,6-Disubstituted Isoquinuclidines as Ibogaine Analogs , 2005 .

[60]  M. Coutlangus,et al.  On the Stereochemistry of Diaryl-Substituted Cyclohexanones Formed by Michael Reactions. Trans to Cis Isomerization of Their Ketals under Basic Conditions , 1998 .

[61]  S. Handy,et al.  Lithium Trifluoromethanesulfonimide in Acetone or Diethyl Ether as a Safe Alternative to Lithium Perchlorate in Diethyl Ether for Effecting Diels-Alder Reactions. Unexpected Influence of the Counterion of Exo/Endo Selectivity , 1995 .

[62]  V. Padmavathi,et al.  SYNTHESIS OF SOME SPIRO-ISOXAZOLIDINE-3,5-DIONES , 1992 .

[63]  H. Hall,et al.  Anti-Bredt bridgehead nitrogen compounds in ring-opening polymerization , 1983 .

[64]  H. Inoue,et al.  Azabicycloalkanes as analgetics. V. 4-Phenyl-2-azabicyclo[2,2,2]octanes. , 1976, Chemical & pharmaceutical bulletin.

[65]  D. Alkalay,et al.  New bicyclic enamines and iminium salts. II. Synthesis of 1,4-dihydro-1,4-ethanoisoquinolinium salts and 4,5-dihydro-1H-1,4-methano-3-benzazepinium salts by reaction of bridged lactams with organometallic reagents , 1971 .

[66]  S. Ricca,et al.  The Alkaloids of Tabernanthe Iboga. VII.1 Derivatives of Isoquinuclidine , 1958 .

[67]  Yunhe Xu,et al.  Palladium-Catalyzed Tandem Heck Cyclization Reactions to Access the Bridged N-Heterocyclic Compounds , 2021, Chinese Journal of Organic Chemistry.

[68]  D. Zheng,et al.  Hypervalent Organoiodine Promoted Dearylation Reaction of N-Aryl Sulfonamides , 2020, Chinese Journal of Organic Chemistry.

[69]  Lin He,et al.  N-Heterocyclic Carbene-Catalyzed Double Michael Addition of Cyano Acetates and Dienones: Diastereoselective Synthesis of Multisubstituted Cyclohexanones and Indanes , 2020, Chinese Journal of Organic Chemistry.

[70]  Xiaowei Li,et al.  Synthesis of Imidazolium Precursors for the Hydroxyl-Group-Modified N-Heterocyclic Carbenes and Applications of the in situ Generated Carbene Ligands in Suzuki-Miyaura and Sonogashira Coupling Reactions , 2017 .

[71]  陈杰,et al.  不对称有机催化Michael加成/半缩醛胺化/酰亚胺正离子环化串联反应研究进展 , 2013 .

[72]  Mazin Nadhim Mousa Al Ugla SYNTHSIS , CHARACTERIZATION AND EVALUATION OF TOPICAL ANTI-INFLAMATORY ACTIVITY OF DIMETHYL 4-OXO-2 , 6-DIPHENYLCYCLOHEXANE-1 , 1-DICARBOXYLATE , 2011 .

[73]  C. Herdeis,et al.  A Facile Entry to the 2-Azabicyclo[2.2.2]octane-6-one Skeleton via [4+2]-Cycloaddition , 1988 .

[74]  B. Gill,et al.  Structures of Marvel's .delta.-lactone and polymer , 1988 .