Single-photon emission computed tomography of the brain in autism: effect of the developmental level.

Brain single-photon emission computed tomography was performed in 22 autistic and 10 nonautistic disabled patients. The regional cerebral blood flow in both laterotemporal and dorso-medio-lateral frontal areas decreased significantly in the autistic group compared with in nonautistic group. In the autistic group, the regional cerebral blood flow was significantly higher in the right temporal and right parietal lobes than that in the left ones. Inversely, the regional cerebral blood flow in the frontal and occipital lobes was significantly higher on the left side than on the right side. In the nonautistic group, except for in the dorso-medio-lateral frontal lobes (left > right), there was no difference in the regional cerebral blood flow in either cerebrum or cerebellum. A positive correlationship between regional cerebral flow and development quotient (intelligence quotient) was observed in the left laterotemporal and both dorso-medio-lateral frontal areas, and a negative one was observed in the cerebellar vermis area. These results suggest that the regional cerebral blood flow decrease in the temporal and frontal areas relates to not only the brain mechanism of autism reported previously but also intelligence levels.

[1]  M S Buchsbaum,et al.  Regional cerebral glucose metabolism and attention in adults with a history of childhood autism. , 1992, The Journal of neuropsychiatry and clinical neurosciences.

[2]  R A Margolin,et al.  Brain metabolism in autism. Resting cerebral glucose utilization rates as measured with positron emission tomography. , 1985, Archives of general psychiatry.

[3]  P. Roland,et al.  Activation of Multi‐modal Cortical Areas Underlies Short‐term Memory , 1996, The European journal of neuroscience.

[4]  B Mazoyer,et al.  Regional cerebral blood flow in childhood autism: a SPECT study. , 1992, The American journal of psychiatry.

[5]  D. F. Preston,et al.  SPECT Brain Imaging Abnormalities in Attention Deficit Hyperactivity Disorder , 1995, Clinical nuclear medicine.

[6]  T. Hashimoto,et al.  Development of the brainstem and cerebellum in autistic patients , 1995, Journal of autism and developmental disorders.

[7]  T. Hashimoto,et al.  Differences in Brain Metabolites Between Patients With Autism and Mental Retardation as Detected by in Vivo Localized Proton Magnetic Resonance Spectroscopy , 1997, Journal of child neurology.

[8]  C. -. Hsu,et al.  Regional cerebral blood flow of Alzheimer's disease-like pattern in young patients with Down's syndrome detected by 99Tcm-HMPAO brain SPECT. , 1993, Nuclear medicine communications.

[9]  Y. Samson,et al.  Delayed maturation of the frontal cortex in childhood autism. , 1995, The American journal of psychiatry.

[10]  S. Niwa,et al.  Brief Report: Electroencephalographic Paroxysmal Activities in the Frontal Area Emerged in Middle Childhood and During Adolescence in a Follow-up Study of Autism , 1997, Journal of autism and developmental disorders.

[11]  J. Hoffman,et al.  Neuroimaging in Infantile Autism , 1994, Journal of child neurology.

[12]  Richard J. Harris,et al.  Event-related potentials in cross-modal divided attention in autism , 1995, Neuropsychologia.

[13]  P. Uvebrant,et al.  Regional cerebral blood flow abnormalities in Rett syndrome. , 1997, European child & adolescent psychiatry.

[14]  M S Buchsbaum,et al.  Anterior cingulate gyrus volume and glucose metabolism in autistic disorder. , 1997, The American journal of psychiatry.

[15]  R. Knight,et al.  Frontal Lobe Contributions to Theory of Mind , 1998, Journal of Cognitive Neuroscience.

[16]  M. Buchsbaum,et al.  Positron emission tomography of the cerebellum in autism. , 1989, The American journal of psychiatry.

[17]  B. Pennington,et al.  Executive functions and developmental psychopathology. , 1996, Journal of child psychology and psychiatry, and allied disciplines.

[18]  J. Mountz,et al.  Functional deficits in autistic disorder: characterization by technetium-99m-HMPAO and SPECT. , 1995, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[19]  R S Frackowiak,et al.  Cerebral blood flow and metabolism of oxygen and glucose in young autistic adults , 1988, Psychological Medicine.

[20]  M. Leboyer,et al.  SPECT OF THE BRAIN IN CHILDHOOD AUTISM: EVIDENCE FOR A LACK OF NORMAL HEMISPHERIC ASYMMETRY , 1995, Developmental medicine and child neurology.

[21]  K Kouris,et al.  Cerebral Blood Flow Abnormalities in Adults with Infantile Autism , 1992, The Journal of nervous and mental disease.

[22]  R. Rothermel,et al.  Altered serotonin synthesis in the dentatothalamocortical pathway in autistic boys , 1997, Annals of neurology.

[23]  T Jones,et al.  Regional cerebral oxygen supply and utilization in dementia. A clinical and physiological study with oxygen-15 and positron tomography. , 1981, Brain : a journal of neurology.

[24]  E. Courchesne,et al.  Hypoplasia of cerebellar vermal lobules VI and VII in autism. , 1988, The New England journal of medicine.

[25]  Eric Courchesne,et al.  Brainstem, cerebellar and limbic neuroanatomical abnormalities in autism , 1997, Current Opinion in Neurobiology.

[26]  A. Volder,et al.  Brain glucose metabolism in children with the autistic syndrome: Positron tomography analysis , 1987, Brain and Development.

[27]  S. Kuperman,et al.  Morphological evidence for brainstem involvement in infantile autism , 1988, Biological Psychiatry.

[28]  Klaus P. Ebmeier,et al.  Alzheimer's disease in adults with Down's syndrome: the relationship between regional cerebral blood flow equivalents and dementia , 1992, Acta psychiatrica Scandinavica.

[29]  J. C. Wu,et al.  Brief report: Attention performance in autism and regional brain metabolic rate assessed by positron emission tomography , 1992, Journal of autism and developmental disorders.

[30]  S Arndt,et al.  An MRI study of the corpus callosum in autism. , 1997, The American journal of psychiatry.

[31]  R. S. J. Frackowiak,et al.  REGIONAL CEREBRAL OXYGEN SUPPLY AND UTILIZATION IN DEMENTIAA CLINICAL AND PHYSIOLOGICAL STUDY WITH OXYGEN-15 AND POSITRON TOMOGRAPHY A CLINICAL AND PHYSIOLOGICAL STUDY WITH OXYGEN - 15 AND POSITRON TOMOHRAPHY , 1981 .