The mesocortical dopamine projection to anterior cingulate cortex plays no role in guiding effort-related decisions.

Both mesolimbic dopamine (DA) and the anterior cingulate cortex (ACC) have been implicated in enabling animals to expend effort to obtain greater reward. To investigate the role of the DA pathway to ACC in working for reward, the authors tested rats on a cost-benefit T-maze paradigm in which they could either climb a barrier to obtain large reward in 1 arm (high reward [HR]) or select the low-effort alternative containing less reward (low reward [LR]). Surprisingly, ACC DA depletions had no effect on choice performance. Manipulations of barrier and reward sizes demonstrated that lesioned rats were as sensitive to the costs and benefits of the alternatives as controls. These results imply that the DA projection to ACC is not involved in guiding effort-related decisions.

[1]  John D. Salamone,et al.  Nucleus accumbens dopamine depletions in rats affect relative response allocation in a novel cost/benefit procedure , 1994, Pharmacology Biochemistry and Behavior.

[2]  A. Phillips,et al.  Modulation by Central and Basolateral Amygdalar Nuclei of Dopaminergic Correlates of Feeding to Satiety in the Rat Nucleus Accumbens and Medial Prefrontal Cortex , 2002, The Journal of Neuroscience.

[3]  Clay B. Holroyd,et al.  The neural basis of human error processing: reinforcement learning, dopamine, and the error-related negativity. , 2002, Psychological review.

[4]  M. Gabriel,et al.  Neurobiology of Cingulate Cortex and Limbic Thalamus: A Comprehensive Handbook , 1993 .

[5]  G. Paxinos,et al.  The Rat Brain in Stereotaxic Coordinates , 1983 .

[6]  M. Walton,et al.  The Role of Rat Medial Frontal Cortex in Effort-Based Decision Making , 2002, The Journal of Neuroscience.

[7]  A. Grace,et al.  Depletion of dopamine in the prefrontal cortex decreases the basal electrophysiological activity of mesolimbic dopamine neurons , 1998, Brain Research.

[8]  G M Rose,et al.  Exposing Rats to a Predator Blocks Primed Burst Potentiation in the Hippocampus In Vitro , 1999, The Journal of Neuroscience.

[9]  A. Gratton,et al.  Changes in Medial Prefrontal Cortical Dopamine Levels Associated with Response-Contingent Food Reward: An Electrochemical Study in Rat , 1998, The Journal of Neuroscience.

[10]  A. Gratton,et al.  Behavior-Relevant Changes in Nucleus Accumbens Dopamine Transmission Elicited by Food Reinforcement: An Electrochemical Study in Rat , 1996, The Journal of Neuroscience.

[11]  J. Salamone,et al.  Nucleus accumbens dopamine depletions make animals highly sensitive to high fixed ratio requirements but do not impair primary food reinforcement , 2001, Neuroscience.

[12]  Matthew F S Rushworth,et al.  Functional Specialization within Medial Frontal Cortex of the Anterior Cingulate for Evaluating Effort-Related Decisions , 2003, The Journal of Neuroscience.

[13]  Linda J. Porrino,et al.  Cortical Mechanisms of Reinforcement , 1993 .

[14]  J. Finlay,et al.  Effects of selective dopamine depletion in medial prefrontal cortex on basal and evoked extracellular dopamine in neostriatum , 1995, Brain Research.

[15]  G. Breese,et al.  Effect of 6-hydroxydopamine on brain norepinephrine and dopamine evidence for selective degeneration of catecholamine neurons. , 1970, The Journal of pharmacology and experimental therapeutics.

[16]  S. Spence,et al.  Cortical and ventral tegmental systems exert opposing influences on self-stimulation from the prefrontal cortex , 1985, Behavioural Brain Research.

[17]  M. Ragozzino.  The contribution of cholinergic and dopaminergic afferents in the rat prefrontal cortex to learning, memory, and attention , 2000, Psychobiology.

[18]  M. Zigmond,et al.  Effects of dopamine depletion in the medial prefrontal cortex on the stress-induced increase in extracellular dopamine in the nucleus accumbens core and shell , 1997, Neuroscience.

[19]  Anders Björklund,et al.  Organization of catecholamine neurons projecting to the frontal cortex in the rat , 1978, Brain Research.

[20]  N. Uretsky,et al.  EFFECTS OF 6‐HYDROXYDOPAMINE ON CATECHOLAMINE CONTAINING NEURONES IN THE RAT BRAIN , 1970, Journal of neurochemistry.

[21]  Patrick R. Hof,et al.  Monoaminergic Innervation of Cingulate Cortex , 1993 .

[22]  J. Salamone,et al.  Motivational views of reinforcement: implications for understanding the behavioral functions of nucleus accumbens dopamine , 2002, Behavioural Brain Research.

[23]  M. Feenstra,et al.  Rapid sampling of extracellular dopamine in the rat prefrontal cortex during food consumption, handling and exposure to novelty , 1996, Brain Research.

[24]  K. Berridge.  Food reward: Brain substrates of wanting and liking , 1996, Neuroscience & Biobehavioral Reviews.

[25]  A. Phillips,et al.  Dopaminergic Correlates of Sensory-Specific Satiety in the Medial Prefrontal Cortex and Nucleus Accumbens of the Rat , 1999, The Journal of Neuroscience.

[26]  M. Walton,et al.  Differential involvement of serotonin and dopamine systems in cost-benefit decisions about delay or effort , 2005, Psychopharmacology.

[27]  R. L. Moss,et al.  In vivo stimulated dopamine release in the nucleus accumbens: modulation by the prefrontal cortex , 1995, Brain Research.

[28]  B. Berger,et al.  Dopaminergic innervation of the frontal cerebral cortex. Evolutionary trends and functional implications. , 1992, Advances in neurology.

[29]  T. Robbins,et al.  Neurobehavioural mechanisms of reward and motivation , 1996, Current Opinion in Neurobiology.

[30]  K. Berridge,et al.  What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? , 1998, Brain Research Reviews.

[31]  D. Richardson,et al.  29 - Effects of Nitrogen Monoxide on Cellular Iron Metabolism , 1996 .

[32]  J. Salamone,et al.  Anhedonia or anergia? Effects of haloperidol and nucleus accumbens dopamine depletion on instrumental response selection in a T-maze cost/benefit procedure , 1994, Behavioural Brain Research.