Bone Bricks: The Effect of Architecture and Material Composition on the Mechanical and Biological Performance of Bone Scaffolds

Large bone loss injuries require high-performance scaffolds with an architecture and material composition resembling native bone. However, most bone scaffold studies focus on three-dimensional (3D) structures with simple rectangular or circular geometries and uniform pores, not able to recapitulate the geometric characteristics of the native tissue. This paper addresses this limitation by proposing novel anatomically designed scaffolds (bone bricks) with nonuniform pore dimensions (pore size gradients) designed based on new lay-dawn pattern strategies. The gradient design allows one to tailor the properties of the bricks and together with the incorporation of ceramic materials allows one to obtain structures with high mechanical properties (higher than reported in the literature for the same material composition) and improved biological characteristics.

[1]  A. Fallah,et al.  Effect of zinc-doped hydroxyapatite/graphene nanocomposite on the physicochemical properties and osteogenesis differentiation of 3D-printed polycaprolactone scaffolds for bone tissue engineering , 2021 .

[2]  Ehab Alshal,et al.  Capitate shortening osteotomy with or without vascularized bone grafting for the treatment of early stages of Kienböck’s disease , 2021, International Orthopaedics.

[3]  W. Cai,et al.  A self-powered implantable and bioresorbable electrostimulation device for biofeedback bone fracture healing , 2021, Proceedings of the National Academy of Sciences.

[4]  M. Singer,et al.  Refracture after Ilizarov fixation of infected ununited tibial fractures—an analysis of eight hundred and twelve cases , 2021, International Orthopaedics.

[5]  E. Malagoli,et al.  Alternative Use of the Ilizarov Apparatus Set in Case of Complications During Intramedullary Nail Removal: A Case Report. , 2021, JBJS case connector.

[6]  R. Malhotra,et al.  Megaprosthesis Versus Allograft Prosthesis Composite for the Management of Massive Skeletal Defects: A Meta-Analysis of Comparative Studies , 2021, Current Reviews in Musculoskeletal Medicine.

[7]  P. Bártolo,et al.  Investigations of Graphene and Nitrogen-Doped Graphene Enhanced Polycaprolactone 3D Scaffolds for Bone Tissue Engineering , 2021, Nanomaterials.

[8]  Shan Gao,et al.  Antibacterial biomaterials in bone tissue engineering. , 2021, Journal of materials chemistry. B.

[9]  A. Bakr,et al.  Characterization and antibacterial activity of Streptomycin Sulfate loaded Bioglass/Chitosan beads for bone tissue engineering , 2021 .

[10]  P. Bártolo,et al.  Investigating the Influence of Architecture and Material Composition of 3D Printed Anatomical Design Scaffolds for Large Bone Defects , 2021, International journal of bioprinting.

[11]  A. Addosooki,et al.  Radial shortening, bone grafting and vascular pedicle implantation versus radial shortening alone in Kienböck’s disease , 2021, The Journal of hand surgery, European volume.

[12]  C. Tuck,et al.  Additive manufacturing of advanced ceramic materials , 2021 .

[13]  Ashley A. Vu,et al.  Effects of surface area and topography on 3D printed tricalcium phosphate scaffolds for bone grafting applications. , 2021, Additive manufacturing.

[14]  E. J. Foster,et al.  Microstructured poly(ether-ether-ketone)-hydroxyapatite composites for bone replacements , 2021 .

[15]  P. Bártolo,et al.  3D printing of silk microparticle reinforced polycaprolactone scaffolds for tissue engineering applications. , 2021, Materials science & engineering. C, Materials for biological applications.

[16]  D. Lahiri,et al.  The influence of bioactive hydroxyapatite shape and size on the mechanical and biodegradation behaviour of magnesium based composite , 2020 .

[17]  Abdalla M. Omar,et al.  The Potential of Polyethylene Terephthalate Glycol as Biomaterial for Bone Tissue Engineering , 2020, Polymers.

[18]  P. Bártolo,et al.  Carbon Nanomaterials for Electro-Active Structures: A Review , 2020, Polymers.

[19]  Y. Yang,et al.  The effects of tubular structure on biomaterial aided bone regeneration in distraction osteogenesis , 2020 .

[20]  Jingchao Jiang,et al.  A novel fabrication strategy for additive manufacturing processes , 2020 .

[21]  P. Bártolo,et al.  Novel Poly(ɛ-caprolactone)/Graphene Scaffolds for Bone Cancer Treatment and Bone Regeneration , 2020, 3D printing and additive manufacturing.

[22]  C. Shuai,et al.  Accelerated degradation of HAP/PLLA bone scaffold by PGA blending facilitates bioactivity and osteoconductivity , 2020, Bioactive materials.

[23]  D. Donati,et al.  Silver-coated megaprosthesis in prevention and treatment of peri-prosthetic infections: a systematic review and meta-analysis about efficacy and toxicity in primary and revision surgery , 2020, European Journal of Orthopaedic Surgery & Traumatology.

[24]  C. Şen,et al.  Combined Technique for the Treatment of Infected Nonunions of the Distal Femur With Bone Loss: Short Supracondylar Nail-Augmented Acute Shortening/Lengthening. , 2020, Journal of orthopaedic trauma.

[25]  P. Morasiewicz,et al.  A new criterion for assessing Ilizarov treatment outcomes in nonunion of the tibia , 2020, Archives of Orthopaedic and Trauma Surgery.

[26]  R. Leijendekkers,et al.  Safety and Performance of Bone-Anchored Prostheses in Persons with a Transfemoral Amputation: A 5-Year Follow-up Study. , 2020, The Journal of bone and joint surgery. American volume.

[27]  Kai Huang,et al.  Using the Ilizarov technique to treat limb shortening after replantation of a severed lower limb: a case report , 2020, Annals of translational medicine.

[28]  Zhengyi Jiang,et al.  Engineered dual-scale poly (ε-caprolactone) scaffolds using 3D printing and rotational electrospinning for bone tissue regeneration , 2020 .

[29]  A. Masquelet,et al.  The Masquelet technique: Current concepts, animal models, and perspectives , 2020, Journal of tissue engineering and regenerative medicine.

[30]  R. Hayda,et al.  Adding a Fibular Strut Allograft to Intramedullary Nail and Cancellous Autograft During Stage II of the Masquelet Technique for Segmental Femur Defects: A Technique Tip , 2020, Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews.

[31]  D. Borzunov,et al.  Role of the Ilizarov non-free bone plasty in the management of long bone defects and nonunion: Problems solved and unsolved. , 2020, World journal of orthopedics.

[32]  P. Bártolo,et al.  Investigating the Effect of Carbon Nanomaterials Reinforcing Poly(ε-Caprolactone) Printed Scaffolds for Bone Repair Applications , 2020, International journal of bioprinting.

[33]  C. Şen,et al.  Combined Technique for the Treatment of Infected Nonunions of the Distal Femur with Bone Loss: Short Supracondylar Nail Augmented Acute Shortening/Lengthening. , 2020, Journal of orthopaedic trauma.

[34]  Nam-Trung Nguyen,et al.  Porous scaffolds for bone regeneration , 2020 .

[35]  A. Masquelet,et al.  Towards Understanding Therapeutic Failures in Masquelet Surgery: First Evidence that Defective Induced Membrane Properties are Associated with Clinical Failures , 2020, Journal of clinical medicine.

[36]  M. McNally,et al.  Comparison of Ilizarov Bifocal, Acute Shortening and Relengthening with Bone Transport in the Treatment of Infected, Segmental Defects of the Tibia , 2020, Journal of clinical medicine.

[37]  Yongqing Xu,et al.  Bone transport versus acute shortening for the management of infected tibial bone defects: a meta-analysis , 2019, BMC Musculoskeletal Disorders.

[38]  S. Boriani,et al.  Function Preservation or Oncological Appropriateness in Spinal Bone Tumors? A Case Series of Segmental Resection of the Spinal Canal Content (Spinal Amputation). , 2019, Spine.

[39]  Yang Liu,et al.  Preparation and properties of dopamine-modified alginate/chitosan-hydroxyapatite scaffolds with gradient structure for bone tissue engineering. , 2019, Journal of biomedical materials research. Part A.

[40]  P. Bártolo,et al.  Rheological characterization of polymer/ceramic blends for 3D printing of bone scaffolds , 2018, Polymer Testing.

[41]  P. Bártolo,et al.  Polymer-Ceramic Composite Scaffolds: The Effect of Hydroxyapatite and β-tri-Calcium Phosphate , 2018, Materials.

[42]  E. Vega-Ávila,et al.  Can the MTT Assay Be Optimized to Assess Cell Proliferation for Use in Cytokine Measurement , 2017 .

[43]  A. Shavandi,et al.  Development and characterization of hydroxyapatite/β-TCP/chitosan composites for tissue engineering applications. , 2015, Materials science & engineering. C, Materials for biological applications.

[44]  R. Borra,et al.  A simple method to measure cell viability in proliferation and cytotoxicity assays. , 2009, Brazilian oral research.

[45]  Qin Zou,et al.  Degradation and biocompatibility of porous nano-hydroxyapatite/polyurethane composite scaffold for bone tissue engineering , 2009 .

[46]  Elliot P. Douglas,et al.  Bone structure and formation: A new perspective , 2007 .

[47]  C K Chua,et al.  Compressive properties and degradability of poly(epsilon-caprolatone)/hydroxyapatite composites under accelerated hydrolytic degradation. , 2007, Journal of biomedical materials research. Part A.

[48]  A Tampieri,et al.  Porosity-graded hydroxyapatite ceramics to replace natural bone. , 2001, Biomaterials.

[49]  K. An,et al.  Mechanical properties of a biodegradable bone regeneration scaffold. , 2000, Journal of biomechanical engineering.

[50]  M W Bidez,et al.  Mechanical properties of trabecular bone in the human mandible: implications for dental implant treatment planning and surgical placement. , 1999, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[51]  Gordon W. Blunn,et al.  Biomanufacturing of customized modular scaffolds for critical bone defects , 2019, CIRP Annals.

[52]  R. Rajkhowa,et al.  Rheological characterization of polymer/ceramic blends for 3D printing of bone scaffolds , 2018 .

[53]  D. Korres,et al.  The effect of hydroxyapatite nanoparticles on crystallization and thermomechanical properties of PLLA matrix , 2016 .

[54]  Marc A. Meyers,et al.  Potential Bone Replacement Materials Prepared by Two Methods , 2012 .