Kv4.3 Modulates the Distribution of hERG

[1]  Bao-Xin Li,et al.  Translational toxicology and rescue strategies of the hERG channel dysfunction: biochemical and molecular mechanistic aspects , 2014, Acta Pharmacologica Sinica.

[2]  C. January,et al.  Large-scale Mutational Analysis of Kv11.1 Reveals Molecular Insights into Type 2 Long QT Syndrome , 2014, Nature Communications.

[3]  Beatriz Trenor,et al.  Electrophysiological and Structural Remodeling in Heart Failure Modulate Arrhythmogenesis. 1D Simulation Study , 2014, PloS one.

[4]  Y. Shao,et al.  VER-155008, a small molecule inhibitor of HSP70 with potent anti-cancer activity on lung cancer cell lines , 2014, Experimental biology and medicine.

[5]  E. Newell,et al.  Regulation of hERG and hEAG Channels by Src and by SHP-1 Tyrosine Phosphatase via an ITIM Region in the Cyclic Nucleotide Binding Domain , 2014, PloS one.

[6]  Ronald Wilders,et al.  Electrophysiological changes in heart failure and their implications for arrhythmogenesis. , 2013, Biochimica et biophysica acta.

[7]  I. Hisatome,et al.  Hsp90 prevents interaction between CHIP and HERG proteins to facilitate maturation of wild-type and mutant HERG proteins. , 2013, Cardiovascular research.

[8]  Gary R. Mirams,et al.  mRNA Expression Levels in Failing Human Hearts Predict Cellular Electrophysiological Remodeling: A Population-Based Simulation Study , 2013, PloS one.

[9]  J. Towbin,et al.  KCNE2 modulation of Kv4.3 current and its potential role in fatal rhythm disorders. , 2010, Heart rhythm.

[10]  J. Nerbonne,et al.  Molecular determinants of cardiac transient outward potassium current (I(to)) expression and regulation. , 2010, Journal of molecular and cellular cardiology.

[11]  M. Drysdale,et al.  A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells , 2010, Cancer Chemotherapy and Pharmacology.

[12]  D. Christini,et al.  Targeted deletion of kcne2 impairs ventricular repolarization via disruption of IK,slow1 and Ito,f , 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[13]  D. Roden.  Repolarization reserve: a moving target. , 2008, Circulation.

[14]  Jørgen K. Kanters,et al.  Functional Effects of KCNE3 Mutation and Its Role in the Development of Brugada Syndrome , 2008, Circulation. Arrhythmia and electrophysiology.

[15]  S. Srai,et al.  Secondary structure of the MiRP1 (KCNE2) potassium channel ancillary subunit. , 2008, Protein and peptide letters.

[16]  Y. Rudy.  Modelling the molecular basis of cardiac repolarization. , 2007, Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.

[17]  A. Shrier,et al.  Co-chaperone FKBP38 Promotes HERG Trafficking* , 2007, Journal of Biological Chemistry.

[18]  J. Nerbonne,et al.  Molecular physiology of cardiac repolarization. , 2005, Physiological reviews.

[19]  M. Janse,et al.  Electrophysiological changes in heart failure and their relationship to arrhythmogenesis. , 2004, Cardiovascular research.

[20]  S. Nattel,et al.  KvLQT1 Modulates the Distribution and Biophysical Properties of HERG , 2004, Journal of Biological Chemistry.

[21]  A. Brown,et al.  Role of the Cytosolic Chaperones Hsp70 and Hsp90 in Maturation of the Cardiac Potassium Channel hERG , 2003, Circulation research.

[22]  J. Papp,et al.  Interaction of different potassium channels in cardiac repolarization in dog ventricular preparations: role of repolarization reserve , 2002, British journal of pharmacology.

[23]  Rebecca A. Ayers,et al.  Interaction with GM130 during HERG Ion Channel Trafficking , 2002, The Journal of Biological Chemistry.

[24]  D. Roden,et al.  Defective Human Ether-à-go-go-related Gene Trafficking Linked to an Endoplasmic Reticulum Retention Signal in the C Terminus* , 2002, The Journal of Biological Chemistry.

[25]  C. January,et al.  Role of glycosylation in cell surface expression and stability of HERG potassium channels. , 2002, American journal of physiology. Heart and circulatory physiology.

[26]  T. McDonald,et al.  14‐3‐3 amplifies and prolongs adrenergic stimulation of HERG K+ channel activity , 2002, The EMBO journal.

[27]  Gea-Ny Tseng,et al.  MinK-Related Peptide 1 Associates With Kv4.2 and Modulates Its Gating Function: Potential Role as &bgr; Subunit of Cardiac Transient Outward Channel? , 2001, Circulation research.

[28]  F. Sesti,et al.  Do all voltage-gated potassium channels use MiRPs? , 2001, Circulation research.

[29]  T. McDonald,et al.  Analysis of the Cyclic Nucleotide Binding Domain of the HERG Potassium Channel and Interactions with KCNE2* , 2001, The Journal of Biological Chemistry.

[30]  R. Winslow,et al.  Role of the Calcium-Independent Transient Outward Current Ito1 in Shaping Action Potential Morphology and Duration , 2000, Circulation research.

[31]  László Virág,et al.  The role of the delayed rectifier component IKs in dog ventricular muscle and Purkinje fibre repolarization , 2000, The Journal of physiology.

[32]  A Shrier,et al.  N‐linked glycosylation sites determine HERG channel surface membrane expression , 1999, The Journal of physiology.

[33]  G. Steinbeck,et al.  Molecular basis of transient outward potassium current downregulation in human heart failure: a decrease in Kv4.3 mRNA correlates with a reduction in current density. , 1998, Circulation.

[34]  C. January,et al.  HERG Channel Dysfunction in Human Long QT Syndrome , 1998, The Journal of Biological Chemistry.

[35]  D. Roden.  Taking the “Idio” out of “Idiosyncratic”: Predicting Torsades de Pointes , 1998, Pacing and clinical electrophysiology : PACE.

[36]  C. January,et al.  Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature. , 1998, Biophysical journal.

[37]  Y Rudy,et al.  Two components of the delayed rectifier K+ current in ventricular myocytes of the guinea pig type. Theoretical formulation and their role in repolarization. , 1995, Circulation research.

[38]  M. Sanguinetti,et al.  A mechanistic link between an inherited and an acquird cardiac arrthytmia: HERG encodes the IKr potassium channel , 1995, Cell.

[39]  R. Kass,et al.  Potassium channels in the heart Cellular, molecular, and clinical implications. , 1993, Trends in cardiovascular medicine.

[40]  R. MacKinnon.  Determination of the subunit stoichiometry of a voltage-activated potassium channel , 1991, Nature.

[41]  D. Roden,et al.  Time-dependent outward current in guinea pig ventricular myocytes. Gating kinetics of the delayed rectifier , 1990, The Journal of general physiology.

[42]  M. Sanguinetti,et al.  Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents , 1990, The Journal of general physiology.