Establishment of a Special Platform for the Research of Prion and the Diagnosis of Human Prion Disease — China’s Studies

The studies of prions and prion disease usually need many special platforms and techniques that differ from those for classical microbes. Search of new biomarkers and establishment of new methods for the diagnosis of human prion diseases are priorities in the field of prion study.

[1]  Wei Zhou,et al.  Validation and Application of Skin RT-QuIC to Patients in China with Probable CJD , 2021, Pathogens.

[2]  Wei Zhou,et al.  Cerebrospinal Fluids from Patients with Five Common Genetic Prion Diseases in China Display Distinct Reactivities in the RT-QuIC Assays. , 2021, Biomedical and environmental sciences : BES.

[3]  Qiang Shi,et al.  Protein amplification technology: new advances in human prion disease diagnosis , 2021, Biosafety and Health.

[4]  Qiang Shi,et al.  Calmodulin level is significantly increased in the cerebrospinal fluid of patients with sporadic Creutzfeldt‐Jakob disease , 2020, European journal of neurology.

[5]  Jing Wang,et al.  Stilbene compounds inhibit the replications of various strains of prions in the levels of cell culture, PMCA and RT-QuIC possibly via molecular binding. , 2020, ACS chemical neuroscience.

[6]  Qiang Shi,et al.  Generation and characterization of two strains of transgene mice expressing chimeric MiniSOG-MusPrP , 2020, Journal of Neuroscience Methods.

[7]  Qiang Shi,et al.  Different post-mortem brain regions from three Chinese FFI patients induce different reactive profiles both in the first and second generation RT-QuIC assays , 2020, Prion.

[8]  W. Zhou,et al.  T188K-Familial Creutzfeldt–Jacob Disease, Predominant Among Chinese, has a Reactive Pattern in CSF RT-QuIC Different from D178N-Fatal Familial Insomnia and E200K-Familial CJD , 2019, Neuroscience Bulletin.

[9]  G. J. Raymond,et al.  Early preclinical detection of prions in the skin of prion-infected animals , 2019, Nature Communications.

[10]  W. Zhou,et al.  Evaluation of the effect of various main elements on the PrPSc detection by real-time quaking-induced conversion assay , 2018, International journal of molecular medicine.

[11]  W. Zhou,et al.  Fatal Familial Insomnia: Insight of the Most Common Genetic Prion Disease in China Based On the Analysis of 40 Patients , 2018 .

[12]  Qiang Shi,et al.  Aberrant alterations of the expressions and S-nitrosylation of calmodulin and the downstream factors in the brains of the rodents during scrapie infection , 2017, Prion.

[13]  J. Zhang,et al.  Protein Misfolding Cyclic Amplification Cross-Species Products of Mouse-Adapted Scrapie Strain 139A and Hamster-Adapted Scrapie Strain 263K with Brain and Muscle Tissues of Opposite Animals Generate Infectious Prions , 2016, Molecular Neurobiology.

[14]  Cao Chen,et al.  Epidemiological characteristics of human prion diseases , 2016, Infectious Diseases of Poverty.

[15]  Jing Wang,et al.  Re-infection of the prion from the scrapie-infected cell line SMB-S15 in three strains of mice, CD1, C57BL/6 and Balb/c , 2016, International journal of molecular medicine.

[16]  Jing Wang,et al.  Treatment of SMB-S15 Cells with Resveratrol Efficiently Removes the PrPSc Accumulation In Vitro and Prion Infectivity In Vivo , 2016, Molecular Neurobiology.

[17]  W. Zhou,et al.  The Levels of Tau Isoforms Containing Exon-2 and Exon-10 Segments Increased in the Cerebrospinal Fluids of the Patients with Sporadic Creutzfeldt-Jakob Disease , 2015, Molecular Neurobiology.

[18]  Qiang Shi,et al.  Preparation of human tau exon-2- and -10-specific monoclonal antibodies for the recognition of brain tau proteins in various mammals. , 2015, International journal of molecular medicine.

[19]  W. Zhou,et al.  Global Protein Differential Expression Profiling of Cerebrospinal Fluid Samples Pooled from Chinese Sporadic CJD and non-CJD Patients , 2014, Molecular Neurobiology.

[20]  Bian-Li Xu,et al.  Comparison of the pathologic and pathogenic features in six different regions of postmortem brains of three patients with fatal familial insomnia. , 2013, International journal of molecular medicine.

[21]  Qiang Shi,et al.  Mouse-adapted scrapie strains 139A and ME7 overcome species barrier to induce experimental scrapie in hamsters and changed their pathogenic features , 2012, Virology Journal.

[22]  Kun Xu,et al.  PrP(Sc) of scrapie 263K propagates efficiently in spleen and muscle tissues with protein misfolding cyclic amplification. , 2009, Virus research.

[23]  Kun Xu,et al.  The propagation of hamster‐adapted scrapie PrPSc can be enhanced by reduced pyridine nucleotide in vitro , 2009, The FEBS journal.