Increased fatty acid synthase as a therapeutic target in androgen‐independent prostate cancer progression

Fatty acid synthase (FAS) performs the anabolic conversion of dietary carbohydrate or protein to fat. FAS expression is low in most normal tissues, but is elevated in many human cancers, including androgen‐sensitive and androgen‐independent prostate cancer.

[1]  S. Wakil,et al.  Fatty acid synthase, a proficient multifunctional enzyme. , 1989, Biochemistry.

[2]  P. Réville,et al.  On the glandular origin of seminal plasma lipids in man , 2009, Andrologia.

[3]  T. Gansler,et al.  Increased expression of fatty acid synthase (OA-519) in ovarian neoplasms predicts shorter survival. , 1997, Human Pathology.

[4]  H. Kolb,et al.  Fatty-acid biosynthesis in man, a pathway of minor importance. Purification, optimal assay conditions, and organ distribution of fatty-acid synthase. , 1986, Biological chemistry Hoppe-Seyler.

[5]  I. Kondo,et al.  Establishment of a new prostatic carcinoma cell line (TSU-Pr1). , 1987, The Journal of urology.

[6]  P. Visca,et al.  Expression of fatty acid synthase (FAS) as a predictor of recurrence in stage I breast carcinoma patients , 1996, Cancer.

[7]  K. A. Klein,et al.  Progression of metastatic human prostate cancer to androgen independence in immunodeficient SCID mice , 1997, Nature Medicine.

[8]  C. Townsend,et al.  Synthesis and antitumor activity of an inhibitor of fatty acid synthase , 2000 .

[9]  J. Swinnen,et al.  Coordinate regulation of lipogenic gene expression by androgens: evidence for a cascade mechanism involving sterol regulatory element binding proteins. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[10]  S. Piantadosi,et al.  Haptoglobin-related protein (Hpr) epitopes in breast cancer as a predictor of recurrence of the disease. , 1989, The New England journal of medicine.

[11]  C. Townsend,et al.  Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts. , 2000, Cancer research.

[12]  B. Nilsson,et al.  Monoclonal antibodies against human prostasomes , 1998, The Prostate.

[13]  P. Dunham,et al.  Differentiation of Na(+)-K+ pumps of low-K+ sheep red blood cells is promoted by Lp membrane antigens. , 1993, The American journal of physiology.

[14]  A. Belldegrun,et al.  Evidence for clonal outgrowth of androgen-independent prostate cancer cells from androgen-dependent tumors through a two-step process. , 1999, Cancer research.

[15]  C. Townsend,et al.  Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. , 2000, Science.

[16]  J. Nelson,et al.  Caveolin expression is decreased following androgen deprivation in human prostate cancer cell lines , 1999, The Prostate.

[17]  G. Pasternack,et al.  Fatty acid synthase (FAS): a target for cytotoxic antimetabolites in HL60 promyelocytic leukemia cells. , 1996, Cancer research.

[18]  A W Partin,et al.  OA-519 (fatty acid synthase) as an independent predictor of pathologic state in adenocarcinoma of the prostate. , 1995, Urology.

[19]  George L. Wright,et al.  Phenotypic and cytogenetic characterization of a cell line derived from primary prostatic carcinoma , 1989, International journal of cancer.

[20]  A. Rashid,et al.  Elevated expression of fatty acid synthase and fatty acid synthetic activity in colorectal neoplasia. , 1997, The American journal of pathology.

[21]  Stuart Smith,et al.  Biosynthesis of Fatty Acids by Lactating Human Breast Epithelial Cells: An Evaluation of the Contribution to the Overall Composition of Human Milk Fat , 1985, Pediatric Research.

[22]  J. Swinnen,et al.  Androgens stimulate fatty acid synthase in the human prostate cancer cell line LNCaP. , 1997, Cancer research.

[23]  Joseph A. DiGiuseppe,et al.  Pharmacological inhibitors of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell lines. , 1998, Cancer research.

[24]  T. Sugino,et al.  Fatty Acid Synthase Is Expressed Mainly in Adult Hormone-sensitive Cells or Cells with High Lipid Metabolism and in Proliferating Fetal Cells1 , 2000 .

[25]  G. Pasternack,et al.  Expression of oncogenic antigen 519 (OA-519) in prostate cancer is a potential prognostic indicator. , 1992, American journal of clinical pathology.

[26]  S. Ōmura The antibiotic cerulenin, a novel tool for biochemistry as an inhibitor of fatty acid synthesis. , 1976, Bacteriological reviews.

[27]  G. Pasternack,et al.  Inhibition of fatty acid synthesis delays disease progression in a xenograft model of ovarian cancer. , 1996, Cancer research.