Environmental endocrine modulators and human health: an assessment of the biological evidence.

Recently, a great deal of attention and interest has been directed toward the hypothesis that exposure, particularly in utero exposure, to certain environmental chemicals might be capable of causing a spectrum of adverse effects as a result of endocrine modulation. In particular, the hypothesis has focused on the idea that certain organochlorine and other compounds acting as weak estrogens have the capability, either alone or in combination, to produce a variety of adverse effects, including breast, testicular and prostate cancer, adverse effects on male reproductive tract, endometriosis, fertility problems, alterations of sexual behavior, learning disability or delay, and adverse effects on immune and thyroid function. While hormones are potent modulators of biochemical and physiological function, the implication that exposure to environmental hormones (e.g., xenoestrogens) has this capability is uncertain. While it is reasonable to hypothesize that exposure to estrogen-like compounds, whatever their source, could adversely affect human health, biological plausibility alone is an insufficient basis for concluding that environmental endocrine modulators have adversely affected humans. Diethylstilbestrol (DES) is a potent, synthetic estrogen administered under a variety of dosing protocols to millions of women in the belief (now known to be mistaken) that it would prevent miscarriage. As a result of this use, substantial in utero exposure to large numbers of male and female offspring occurred. Numerous studies have been conducted on the health consequences of in utero DES exposure among the adult offspring of these women. There are also extensive animal data on the effects of DES and there is a high degree of concordance between effects observed in animals and humans. The extensive human data in DES-exposed cohorts provide a useful basis for assessing the biological plausibility that potential adverse effects might occur following in utero exposure to compounds identified as environmental estrogens. The effects observed in both animals and humans following in utero exposure to sufficient doses of DES are consistent with basic principles of dose response as well as the possibility of maternal dose levels below which potential non-cancer effects may not occur. Significant differences in estrogenic potency between DES and chemicals identified to date as environmental estrogens, as well as an even larger number of naturally occurring dietary phytoestrogens, must be taken into account when inferring potential effects from in utero exposure to any of these substances. The antiestrogenic properties of many of these same exogenous compounds might also diminish net estrogenic effects. Based on the extensive data on DES-exposed cohorts, it appears unlikely that in utero exposure to usual levels of environmental estrogenic substances, from whatever source, would be sufficient to produce many of the effects (i.e., endometriosis, adverse effects on the male reproductive tract, male and female fertility problems, alterations of sexual behavior, learning problems, immune system effects or thyroid effects) hypothesized as potentially resulting from exposure to chemicals identified to date as environmental estrogens.

[1]  D. Thomas,et al.  Oral contraceptives and breast cancer: review of the epidemiologic literature. , 1991, Contraception.

[2]  P. Magnus,et al.  The familial risk of endometriosis , 1993, Acta obstetricia et gynecologica Scandinavica.

[3]  A. B. Barnes,et al.  Fertility and outcome of pregnancy in women exposed in utero to diethylstilbestrol. , 1980, The New England journal of medicine.

[4]  J. Manson,et al.  Plasma organochlorine levels and the risk of breast cancer. , 1997, The New England journal of medicine.

[5]  M. Longnecker,et al.  Lifetime alcohol consumption and breast cancer risk among postmenopausal women in Los Angeles. , 1995, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[6]  M. Pike,et al.  Aetiology of testicular cancer: association with congenital abnormalities, age at puberty, infertility, and exercise , 1994, BMJ.

[7]  J. Turiel,et al.  Long-term effects of exposure to diethylstilbestrol. , 1988, The Western journal of medicine.

[8]  S. Barnes,et al.  Potential role of dietary isoflavones in the prevention of cancer. , 1994, Advances in experimental medicine and biology.

[9]  M. Romkes,et al.  2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds as antioestrogens: characterization and mechanism of action. , 1991, Pharmacology & toxicology.

[10]  T. Kalland Reduced natural killer activity in female mice after neonatal exposure to diethylstilbestrol. , 1980, Journal of immunology.

[11]  C. Hughes,et al.  Reproductive and general metabolic effects of phytoestrogens in mammals. , 1989, Reproductive toxicology.

[12]  R. Hoover,et al.  The risk of breast cancer after estrogen and estrogen-progestin replacement. , 1989, The New England journal of medicine.

[13]  W. Willett,et al.  Dietary fat and the risk of breast cancer. , 1987, The New England journal of medicine.

[14]  T. Kalland Decreased and disproportionate T-cell population in adult mice after neonatal exposure to diethylstilbestrol. , 1980, Cellular immunology.

[15]  M. Schlumpf,et al.  Prenatal nicotine affects fetal testosterone and sexual dimorphism of saccharin preference , 1985, Pharmacology Biochemistry and Behavior.

[16]  J Benichou,et al.  Proportion of breast cancer cases in the United States explained by well-established risk factors. , 1995, Journal of the National Cancer Institute.

[17]  B. Henderson,et al.  Cancers of the prostate and breast among Japanese and white immigrants in Los Angeles County. , 1991, British Journal of Cancer.

[18]  R. Menkveld,et al.  Possible changes in male fertility over a 15-year period. , 1986, Archives of andrology.

[19]  W. London,et al.  Endemic goiter in Northern Virginia. , 1967, The Journal of clinical endocrinology and metabolism.

[20]  H. Kanzaki,et al.  Suppression of natural killer cell activity by sera from patients with endometriosis. , 1992, American journal of obstetrics and gynecology.

[21]  Goldstein Dp,et al.  Incompetent Cervix in Offspring Exposed to Diethylstilbestrol in Utero , 1978, Obstetrics and gynecology.

[22]  R. Stapley,et al.  Toxicological consequences of Aroclor 1254 ingestion by female rhesus (Macaca mulatta) monkeys. Part 1A. Prebreeding phase: clinical health findings. , 1993, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[23]  C. A. Harris,et al.  Synergy between synthetic oestrogens? , 1997, Nature.

[24]  P. Boyle,et al.  Risk factors for prostate and testicular cancer. , 1993, European journal of cancer.

[25]  S. Safe,et al.  Environmental and dietary estrogens and human health: is there a problem? , 1995, Environmental health perspectives.

[26]  E. Whitehead,et al.  Genital abnormalities and abnormal semen analyses in male patients exposed to diethylstilbestrol in utero. , 1981, The Journal of urology.

[27]  K. Muse,et al.  How does mild endometriosis cause infertility? , 1982, Fertility and sterility.

[28]  J. Wheeler,et al.  The relationship of endometriosis to spontaneous abortion , 1983 .

[29]  M. Bibbo,et al.  A twenty-five-year follow-up study of women exposed to diethylstilbestrol during pregnancy. , 1978, The New England journal of medicine.

[30]  M. Parvinen,et al.  Testicular toxicity and mutagenicity of steroidal and non-steroidal estrogens in the male mouse. , 1991, Mutation research.

[31]  W. Dieckmann,et al.  Does the administration of diethylstilbestrol during pregnancy have therapeutic value? , 1953, American journal of obstetrics and gynecology.

[32]  J. McLachlan,et al.  Synergistic effect of environmental estrogens: report withdrawn. , 1997, Science.

[33]  L. Brinton,et al.  Estrogen replacement therapy and breast cancer risk. , 1993, Epidemiologic reviews.

[34]  R. K. Miller,et al.  Perinatal toxicology: its recognition and fundamentals. , 1983, American journal of industrial medicine.

[35]  H. Jansen,et al.  Estrogenic and antiestrogenic actions of PCBs in the female rat: in vitro and in vivo studies. , 1993, Reproductive toxicology.

[36]  B. Palmer,et al.  Vitellogenin induction by xenobiotic estrogens in the red-eared turtle and African clawed frog. , 1995, Environmental health perspectives.

[37]  C. Luke,et al.  Trends in prostate cancer incidence and mortality rates in South Australia, 1977‐1993 , 1995, The Medical journal of Australia.

[38]  W. Pizzi,et al.  Monosodium glutamate admlinistration to the newborn reduces reproductive ability in female and male mice. , 1977, Science.

[39]  A. Osterlind Diverging trends in incidence and mortality of testicular cancer in Denmark, 1943-1982. , 1986, British journal of cancer.

[40]  Maria Teresa Landi,et al.  Cancer Incidence in a Population Accidentally Exposed to 2,3,7,8‐Tetrachlorodibenzo-para‐dioxin , 1993, Epidemiology.

[41]  B. V. VON Schoultz,et al.  Estrogen replacement therapy and the mixed lymphocyte reaction. , 1981, American journal of obstetrics and gynecology.

[42]  G. Colditz,et al.  Oral contraceptives and breast cancer review and meta‐analysis , 1990, Cancer.

[43]  K. Kreiss Studies on populations exposed to polychlorinated biphenyls. , 1985, Environmental health perspectives.

[44]  M. Shibuya,et al.  Genistein, a specific inhibitor of tyrosine-specific protein kinases. , 1987, The Journal of biological chemistry.

[45]  K. Banovac,et al.  Alterations in thyroxine metabolism produced by cutaneous application of microscope immersion oil: effects due to polychlorinated biphenyls. , 1976, Endocrinology.

[46]  I. Ward,et al.  Prenatal stress feminizes juvenile play patterns in male rats , 1991, Physiology & Behavior.

[47]  D. Trichopoulos,et al.  Breast size, handedness and breast cancer risk. , 1991, European journal of cancer.

[48]  C. Hughes,et al.  Phytochemical mimicry of reproductive hormones and modulation of herbivore fertility by phytoestrogens. , 1988, Environmental health perspectives.

[49]  H. B. Daly,et al.  Neonatal Behavioral Assessment Scale Performance in Humans Influenced by Maternal Consumption of Environmentally Contaminated Lake Ontario Fish , 1996 .

[50]  T. Heeren,et al.  Breast cancer in mothers prescribed diethylstilbestrol in pregnancy: Further follow‐up , 1993, JAMA.

[51]  G. Sant,et al.  Seminoma and epididymal cysts in a young man with known diethylstilbestrol exposure in utero. , 1983, JAMA.

[52]  J. Jefferys,et al.  Studies of transformer repair workers exposed to PCBs: II. Results of clinical laboratory investigations. , 1988, American journal of industrial medicine.

[53]  A R Woodward,et al.  Developmental abnormalities of the gonad and abnormal sex hormone concentrations in juvenile alligators from contaminated and control lakes in Florida. , 1994, Environmental health perspectives.

[54]  R M McClain,et al.  Thyroid gland neoplasia: non-genotoxic mechanisms. , 1992, Toxicology letters.

[55]  H. Tryphonas,et al.  Prevalence of Endometriosis in Rhesus (Macaca mulatta) Monkeys Ingesting PCB (Aroclor 1254): Review and Evaluation , 1996 .

[56]  L. Gray,et al.  Environmental hormone disruptors: evidence that vinclozolin developmental toxicity is mediated by antiandrogenic metabolites. , 1994, Toxicology and applied pharmacology.

[57]  J. Jacobson,et al.  Effects of exposure to PCBs and related compounds on growth and activity in children. , 1990, Neurotoxicology and teratology.

[58]  L. Brinton Menopause and the Risk of Breast Cancer , 1990, Annals of the New York Academy of Sciences.

[59]  A. Morrison Cryptorchidism, hernia, and cancer of the testis. , 1976, Journal of the National Cancer Institute.

[60]  J. Cohen,et al.  Decline in sperm counts: an artefact of changed reference range of “normal”? , 1994, BMJ.

[61]  J. Sampson The development of the implantation theory for the origin of peritoneal endometriosis , 1940 .

[62]  K. Chang,et al.  Polychlorinated biphenyls and polychlorinated dibenzofurans in the toxic rice-bran oil that caused PCB poisoning in Taichung , 1981, Bulletin of environmental contamination and toxicology.

[63]  L. C. Miller,et al.  Diethylstilbestrol exposure in utero and endometriosis in infertile females. , 1984, Fertility and sterility.

[64]  R. Williamson,et al.  Genital tract examinations and zona-free hamster egg penetration tests from men exposed in utero to diethylstilbestrol. , 1984, Fertility and sterility.

[65]  J. McLachlan,et al.  Lesions of the rete testis in mice exposed prenatally to diethylstilbestrol. , 1985, Cancer research.

[66]  S. Safe,et al.  Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), and dibenzofurans (PCDFs) as antiestrogens in MCF-7 human breast cancer cells: quantitative structure-activity relationships. , 1993, Toxicology and applied pharmacology.

[67]  C Sonnenschein,et al.  The pesticides endosulfan, toxaphene, and dieldrin have estrogenic effects on human estrogen-sensitive cells. , 1994, Environmental health perspectives.

[68]  K. Rothman Is breast cancer initiated in utero , 1990 .

[69]  A. Herbst,et al.  Adenocarcinoma of the vagina. Association of maternal stilbestrol therapy with tumor appearance in young women. , 1971, The New England journal of medicine.

[70]  Stuart E. Smith,et al.  WISC—R Subtest Reliability over Time: Implications for Practice and Research , 1994, Psychological reports.

[71]  D. Rose,et al.  High-fiber diet reduces serum estrogen concentrations in premenopausal women. , 1991, The American journal of clinical nutrition.

[72]  K. Chae,et al.  Estrogen receptor-binding activity of polychlorinated hydroxybiphenyls: conformationally restricted structural probes. , 1988, Molecular pharmacology.

[73]  J L Kelsey,et al.  Breast cancer: magnitude of the problem and descriptive epidemiology. , 1993, Epidemiologic reviews.

[74]  D. Edelman,et al.  Reproductive history of women exposed to diethylstilbestrol in utero. , 1980, Fertility and sterility.

[75]  N. Berman,et al.  Data from men in greater Seattle area reveals no downward trend in semen quality: further evidence that deterioration of semen quality is not geographically uniform * † , 1996 .

[76]  Robert Mittendorf,et al.  Lactation and a reduced risk of premenopausal breast cancer , 1994 .

[77]  J. Clausen,et al.  Organochlorine compounds in human breast fat from deceased with and without breast cancer and in a biopsy material from newly diagnosed patients undergoing breast surgery. , 1984, Environmental research.

[78]  D. Trichopoulos Hypothesis: does breast cancer originate in utero? , 1990, The Lancet.

[79]  John Webster,et al.  Goodman and Gilman's the Pharmacological Basis of Therapeutics, 8th ed , 1992 .

[80]  R. Levine,et al.  Differences in the Quality of Semen in Outdoor Workers during Summer and Winter , 1990 .

[81]  J. Leatherland Field Observations on Reproductive and Developmental Dysfunction in Introduced and Native Salmonids from the Great Lakes , 1993 .

[82]  L. Gray,et al.  Persistent DDT metabolite p,p'–DDE is a potent androgen receptor antagonist , 1995, Nature.

[83]  D. Goldstein,et al.  Impaired Reproductive Performance in DES-Exposed Women , 1980, Obstetrics and gynecology.

[84]  W. Heinrichs,et al.  DDT Administered to Neonatal Rats Induces Persistent Estrus Syndrome , 1971, Science.

[85]  L. Gray,et al.  Alteration of behavioral sex differentiation by exposure to estrogenic compounds during a critical neonatal period: effects of zearalenone, methoxychlor, and estradiol in hamsters. , 1985, Toxicology and applied pharmacology.

[86]  C. Mansfield A review of the etiology of breast cancer. , 1993, Journal of the National Medical Association.

[87]  Y. Masuda,et al.  Comparison of causal agents in Taiwan and Fukuoka PCB poisonings , 1982 .

[88]  D. Olive,et al.  Medical progress : endometriosis , 1993 .

[89]  A. Conney,et al.  Estrogenic action of DDT and its analogs. , 1969, Toxicology and applied pharmacology.

[90]  F. Fan,et al.  Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on humoral and cell-mediated immunity in Sprague-Dawley rats. , 1996, Toxicology.

[91]  D. Sager,et al.  Long-term effects on reproductive parameters in female rats after translactational exposure to PCBs. , 1994, Environmental research.

[92]  J. McLachlan,et al.  Lesions of testis and epididymis associated with prenatal diethylstilbestrol exposure. , 1988, Environmental health perspectives.

[93]  D. V. van Thiel,et al.  Isolation and identification of phytoestrogens from beer. , 1992, Alcoholism, clinical and experimental research.

[94]  T. Yoshimura,et al.  Relationship between the amount of rice oil ingested by patients with yusho and their subjective symptoms. , 1985, Environmental health perspectives.

[95]  Y. Masuda Approach to risk assessment of chlorinated dioxins from Yusho PCB poisoning. , 1996, Chemosphere.

[96]  R. Peterson,et al.  Reproductive toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in male rats: different effects of in utero versus lactational exposure. , 1994, Toxicology and applied pharmacology.

[97]  S. Schantz,et al.  Effects of perinatal exposure to specific PCB congeners on thyroid hormone concentrations and thyroid histology in the rat. , 1993, Toxicology letters.

[98]  R. Gorski,et al.  Prenatal inhibition of hypothalamic sex steroid uptake by cocaine: effects on neurobehavioral sexual differentiation in male rats. , 1990, Brain research. Developmental brain research.

[99]  Daniel P. Stites,et al.  Basic and Clinical Immunology , 1976 .

[100]  M. Vessey,et al.  A randomized double‐blind controlled trial of the value of stilboestrol therapy in pregnancy: long‐term follow‐up of mothers and their offspring , 1983, British journal of obstetrics and gynaecology.

[101]  M. Bibbo,et al.  Follow‐up Study of Male and Female Offspring of DES‐Exposed Mothers , 1977, Obstetrics and gynecology.

[102]  S. Leto,et al.  Changing parameters of donor semen. , 1981, Fertility and sterility.

[103]  P. Ever-Hadani,et al.  Some organochlorine insecticide and polychlorinated biphenyl blood residues in infertile males in the general Israeli population of the middle 1980's , 1987, Archives of environmental contamination and toxicology.

[104]  Elizabeth Hatch,et al.  Diethylstilbestrol Revisited: A Review of the Long-Term Health Effects , 1995, Annals of Internal Medicine.

[105]  H. Mussalo-Rauhamaa,et al.  Occurrence of beta‐hexachlorocyclohexane in breast cancer patients , 1990, Cancer.

[106]  J. Kelsey Breast cancer epidemiology: summary and future directions. , 1993, Epidemiologic reviews.

[107]  H. Bern,et al.  Reproductive abnormalities in female mice exposed neonatally to various doses of coumestrol. , 1990, Journal of toxicology and environmental health.

[108]  T. Kalland,et al.  Effect of estrogen and corticosterone on the lymphoid system in neonatal mice. , 1978, Experimental and molecular pathology.

[109]  M. Meurer,et al.  Chlamydia trachomatis induces an inflammatory response in the male genital tract and is associated with altered semen quality. , 1991, Fertility and sterility.

[110]  A. B. Barnes,et al.  Vaginal Epithelial Changes in Young Women Enrolled in the National Cooperative Diethylstilbestrol Adenosis (DESAD) Project , 1979, Obstetrics and gynecology.

[111]  R. Dixon,et al.  Occupational exposures associated with male reproductive dysfunction. , 1985, Annual review of pharmacology and toxicology.

[112]  W. Heinrichs,et al.  Effects of neonatally-administered DDT homologs on reproductive function in male and female rats. , 1974, Neuroendocrinology.

[113]  J. Halme,et al.  3 Endometriosis: The host response , 1993 .

[114]  D. Lerda Study of sperm characteristics in persons occupationally exposed to lead. , 1992, American journal of industrial medicine.

[115]  J. Jacobson Prenatal exposure to environmental toxin: A test of the multiple effects model. , 1984 .

[116]  Shapiro Ss,et al.  Longitudinal study of semen quality in Wisconsin men over one decade. , 1992 .

[117]  R. Bowman,et al.  Correlation of PCB body burden with behavioral toxicology in monkeys , 1978, Pharmacology Biochemistry and Behavior.

[118]  B C Gladen,et al.  Development after exposure to polychlorinated biphenyls and dichlorodiphenyl dichloroethene transplacentally and through human milk. , 1988, The Journal of pediatrics.

[119]  G. Colditz,et al.  Hormone replacement therapy and risk of breast cancer: results from epidemiologic studies. , 1993, American journal of obstetrics and gynecology.

[120]  H. Adami,et al.  Organochlorine compounds in relation to breast cancer, endometrial cancer, and endometriosis: an assessment of the biological and epidemiological evidence. , 1995, Critical reviews in toxicology.

[121]  J. Godbold,et al.  Pesticides and polychlorinated biphenyl residues in human breast lipids and their relation to breast cancer. , 1992, Archives of environmental health.

[122]  S. Tanabe,et al.  Isomer‐specific determination and toxic evaluation of potentially hazardous coplanar PCBs, dibenzofurans and dioxins in the tissues of “Yusho” PCB poisoning victim and in the causal oil , 1989 .

[123]  E. Bendvold Semen quality in Norwegian men over a 20-year period. , 1989, International journal of fertility.

[124]  P. Stolley,et al.  A case-control study of testicular cancer using Connecticut tumour registry data. , 1988, International journal of epidemiology.

[125]  R. Kaufman,et al.  Upper genital tract changes associated with exposure in utero to diethylstilbestrol. , 1977, Obstetrical & gynecological survey.

[126]  G. Beebe,et al.  Breast cancer incidence among atomic bomb survivors, Hiroshima and Nagasaki, 1950-69. , 1977, Journal of the National Cancer Institute.

[127]  M. Waer,et al.  Women with endometriosis show a defect in natural killer activity resulting in a decreased cytotoxicity to autologous endometrium. , 1991, Fertility and sterility.

[128]  D. Trichopoulos,et al.  A unifying concept of the aetiology of breast cancer , 1988, International journal of cancer.

[129]  M. Whorton,et al.  Sperm count results from 861 American chemical/agricultural workers from 14 separate studies. , 1984, Fertility and sterility.

[130]  N. Day,et al.  The effect of long‐term exposure to DDT on CF‐1 mice , 1972, International journal of cancer.

[131]  W. Willett,et al.  Breast cancer (1) , 1992, The New England journal of medicine.

[132]  S. Safe,et al.  Antiestrogenic activity of hydroxylated polychlorinated biphenyl congeners identified in human serum. , 1997, Toxicology and applied pharmacology.

[133]  J. Allen,et al.  Hormonal alterations in female rhesus monkeys fed a diet containing 2,3,7,8-tetrachlorodibenzo-p-dioxin , 1979, Bulletin of environmental contamination and toxicology.

[134]  B. Henderson,et al.  Male genitourinary abnormalities and maternal diethylstilbestrol. , 1977, The Journal of urology.

[135]  R. Sherins Are semen quality and male fertility changing? , 1995, The New England journal of medicine.

[136]  Y. L. Guo,et al.  Different congeners of PCBs/PCDFs may have contributed to different health outcomes in the Yucheng cohort. , 1996, Neurotoxicology and teratology.

[137]  A. Bartke,et al.  Perinatal exposure to cannabinoids alters male reproductive function in mice. , 1979, Science.

[138]  J. Velázquez-Moctezuma,et al.  The effect of prenatal stress on adult sexual behavior in rats depends on the nature of the stressor , 1993, Physiology & Behavior.

[139]  W. Krause,et al.  Decreasing quality of semen. , 1992, BMJ.

[140]  M. Pike,et al.  Risk factors for cancer of the testis in young men , 1979, International journal of cancer.

[141]  Pierre Jouannet,et al.  Decline in Semen Quality among Fertile Men in Paris during the Past 20 Years , 1995 .

[142]  J. Radomski,et al.  The determination of pesticides in tissues with the electron capture detector without prior clean-up. , 1965, Industrial medicine & surgery.

[143]  J. McLachlan,et al.  Developmental estrogenization and prostatic neoplasia , 1994, The Prostate.

[144]  M. Bracken,et al.  Occupationally related magnetic field exposure and male subfertility. , 1995, Fertility and sterility.

[145]  L. Birnbaum,et al.  Comparative ability of various PCBs, PCDFs, and TCDD to induce cytochrome P450 1A1 and 1A2 activity following 4 weeks of treatment. , 1993, Fundamental and applied toxicology : official journal of the Society of Toxicology.

[146]  J. Weisz,et al.  Maternal stress alters plasma testosterone in fetal males. , 1980, Science.

[147]  N. Boyd,et al.  A meta-analysis of studies of dietary fat and breast cancer risk. , 1993, British Journal of Cancer.

[148]  S. Barnes,et al.  Soy intake and cancer risk: a review of the in vitro and in vivo data. , 1994, Nutrition and cancer.

[149]  W M O'Fallon,et al.  Cryptorchism and maternal estrogen exposure. , 1984, American journal of epidemiology.

[150]  H. Fisch,et al.  Geographic variations in sperm counts: a potential cause of bias in studies of semen quality. , 1996, Fertility and sterility.

[151]  R M Sharpe,et al.  Declining sperm counts in men--is there an endocrine cause? , 1993, The Journal of endocrinology.

[152]  A. Retik,et al.  The spectrum of genitourinary abnormalities in patients with cryptorchidism, with emphasis on testicular carcinoma , 1982, Cancer.

[153]  T. Derouen,et al.  Epidemiology of endemic goitre in western Colombia. , 1978, Bulletin of the World Health Organization.

[154]  L. Birnbaum,et al.  Promotion of endometriosis by 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats and mice: time-dose dependence and species comparison. , 1996, Toxicology and applied pharmacology.

[155]  W. Willett,et al.  A PROSPECTIVE COHORT STUDY OF POSTMENOPAUSAL HORMONE USE AND RISK OF BREAST CANCER IN US WOMEN , 1987 .

[156]  M. Bracken,et al.  Association of cocaine use with sperm concentration, motility, and morphology. , 1990, Fertility and sterility.

[157]  B. Ettinger,et al.  Reduced Mortality Associated With Long‐Term Postmenopausal Estrogen Therapy , 1996, Obstetrics and gynecology.

[158]  P. Whitten,et al.  A phytoestrogen diet induces the premature anovulatory syndrome in lactationally exposed female rats. , 1993, Biology of reproduction.

[159]  J. McLachlan,et al.  Uterine adenocarcinoma in mice following developmental treatment with estrogens: a model for hormonal carcinogenesis. , 1990, Cancer research.

[160]  L. Melton,et al.  Endometriosis and infertility: a laparoscopic study of endometriosis among fertile and infertile women. , 1982, Fertility and sterility.

[161]  M. Alper,et al.  Intractable primary infertility in women exposed to diethylstilbestrol in utero. , 1986, The Journal of reproductive medicine.

[162]  A Chiarodo,et al.  National Cancer Institute roundtable on prostate cancer: future research directions. , 1991, Cancer research.

[163]  A. von zur Mühlen,et al.  The rat as model for the study of drug effects on thyroid function: consideration of methodological problems. , 1979, Pharmacology & therapeutics. Part B: General & systematic pharmacology.

[164]  Gardner Wa,et al.  The prostate--overview: recent insights and speculations. , 1992 .

[165]  W. Heinrichs,et al.  DDT homologues: estrogen-like effects on the vagina, uterus and pituitary of the rat. , 1972, Endocrinology.

[166]  S. Shapiro,et al.  Breast cancer before age 45 and oral contraceptive use: new findings. , 1989, American journal of epidemiology.

[167]  E. Thomas Endometriosis: still an enigma , 1993, British journal of obstetrics and gynaecology.

[168]  M E Hovinga,et al.  Historical changes in serum PCB and DDT levels in an environmentally-exposed cohort , 1992, Archives of environmental contamination and toxicology.

[169]  Y. L. Guo,et al.  Musculoskeletal changes in children prenatally exposed to polychlorinated biphenyls and related compounds (Yu-Cheng children). , 1994, Journal of toxicology and environmental health.

[170]  J. Strain,et al.  DDT (dicophane) and postmenopausal breast cancer in Europe: case-control study , 1997, BMJ.

[171]  A. Herbst,et al.  Infertility among daughters either exposed or not exposed to diethylstilbestrol. , 1988, American journal of obstetrics and gynecology.

[172]  H. Sangi-Haghpeykar,et al.  Epidemiology of Endometriosis Among Parous Women , 1995, Obstetrics and gynecology.

[173]  E. Bostofte,et al.  Has the fertility of Danish men declined through the years in terms of semen quality? A comparison of semen qualities between 1952 and 1972. , 1983, International journal of fertility.

[174]  H A Anderson,et al.  Fish consumption and reproductive outcomes in Green Bay, Wisconsin. , 1992, Environmental research.

[175]  R. Faith,et al.  Effect of in utero exposure to diethylstilbestrol on the immune response in mice. , 1979, Toxicology and applied pharmacology.

[176]  A. Swerdlow The epidemiology of testicular cancer. , 1993, European urology.

[177]  R. McGivern,et al.  Altered adult sexual behavior in the male rat following chronic prenatal hypoxia. , 1993, Neurotoxicology and teratology.

[178]  W. Dmowski,et al.  The role of cell-mediated immunity in pathogenesis of endometriosis. , 1994, Acta obstetricia et gynecologica Scandinavica. Supplement.

[179]  R. McGivern,et al.  Prenatal alcohol exposure alters adult expression of sexually dimorphic behavior in the rat. , 1984, Science.

[180]  D. Brusick,et al.  A comparison of the genotoxic properties of tris(2,3-dibromopropyl)phosphate and tris(1,3-dichloro-2-propyl)phosphate in a battery of short-term bioassays. , 1979, Journal of environmental pathology and toxicology.

[181]  B. Katzenellenbogen,et al.  Estrogenic activity of the insecticide chlordecone (Kepone) and interaction with uterine estrogen receptors. , 1979, Proceedings of the National Academy of Sciences of the United States of America.

[182]  S. Safe,et al.  Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment. , 1994, Critical reviews in toxicology.

[183]  S. Schantz Developmental neurotoxicity of PCBs in humans: what do we know and where do we go from here? , 1996, Neurotoxicology and teratology.

[184]  A. B. Barnes,et al.  Structural anomalies of the cervix and vagina in women enrolled in the Diethylstilbestrol Adenosis (DESAD) Project. , 1984, American journal of obstetrics and gynecology.

[185]  L. Johnson,et al.  Spermatogenesis and aging in the human. , 1986, Journal of andrology.

[186]  S. Barnes,et al.  Genistein, daidzein, and their .beta.-glycoside conjugates: antitumor isoflavones in soybean foods from American and Asian diets , 1993 .

[187]  D. Davis,et al.  Effects of pesticides on the ratio of 16 alpha/2-hydroxyestrone: a biologic marker of breast cancer risk. , 1995, Environmental health perspectives.

[188]  K. Imaida,et al.  Effects of testosterone, dihydrotestosterone and estrogen on 3,2′‐dimethyl‐4‐aminobiphenyl‐induced rat prostate carcinogenesis , 1994, International journal of cancer.

[189]  C. Lowe,et al.  Maternal age and birth rank of women with breast cancer. , 1980, Journal of the National Cancer Institute.

[190]  C. Hoff,et al.  In vitro lymphocyte activity in women with endometriosis--an altered immune response? , 1992, Fertility and sterility.

[191]  N. Weiss,et al.  Use of electric blankets and risk of testicular cancer. , 1990, American journal of epidemiology.

[192]  C. Scorer,et al.  The Incidence of Incomplete Descent of the Testicle at Birth , 1956, Archives of disease in childhood.

[193]  A. Bartke,et al.  Cannabinoids in male mice: effects on fertility and spermatogenesis. , 1982, Science.

[194]  J. Kelsey,et al.  Regional differences in known risk factors and the higher incidence of breast cancer in San Francisco. , 1997, Journal of the National Cancer Institute.

[195]  J. McLachlan,et al.  Reproductive tract lesions in male mice exposed prenatally to diethylstilbestrol , 1975, Science.

[196]  B C Gladen,et al.  Polychlorinated biphenyls (PCBs) and dichlorodiphenyl dichloroethene (DDE) in human milk: effects of maternal factors and previous lactation. , 1986, American journal of public health.

[197]  C. Capen Pathophysiology of chemical injury of the thyroid gland. , 1992, Toxicology letters.

[198]  M. Fujishima,et al.  Thyroid function in "yusho" patients exposed to polychlorinated biphenyls (PCB). , 1987, Environmental research.

[199]  D. N. Kirk,et al.  Nonsteroidal estrogens of dietary origin: possible roles in hormone-dependent disease. , 1984, The American journal of clinical nutrition.

[200]  J. Vena,et al.  Occupational exposure to extreme temperature and risk of testicular cancer. , 1995, Archives of environmental health.

[201]  N. Skakkebæk,et al.  The possible role of sex hormones in the development of testicular cancer. , 1993 .

[202]  L. Lipworth Epidemiology of breast cancer. , 1995, European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation.

[203]  C. Weinberg,et al.  Dietary intervention study to assess estrogenicity of dietary soy among postmenopausal women. , 1995, The Journal of clinical endocrinology and metabolism.

[204]  J. Overstreet,et al.  Infertility in the Male , 1985 .

[205]  R. Kimbrough Laboratory and human studies on polychlorinated biphenyls (PCBs) and related compounds. , 1985, Environmental health perspectives.

[206]  S. Sukumar,et al.  Multistage prostate carcinogenesis: the role of hormones. , 1991, Princess Takamatsu symposia.

[207]  L. Birnbaum,et al.  Promotion of endometriosis in mice by polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls. , 1997, Environmental health perspectives.

[208]  C. Wade,et al.  Results of a two-year chronic toxicity and oncogenicity study of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats. , 1978, Toxicology and applied pharmacology.

[209]  D. Martineau,et al.  Possible mechanisms of action of environmental contaminants on St. Lawrence beluga whales (Delphinapterus leucas). , 1995, Environmental health perspectives.

[210]  R. Abonour,et al.  Immune abnormalities associated with chronic TCDD exposure in Rhesus , 1989 .

[211]  S. Finch,et al.  Prenatal ‘female hormone’ administration and psychosexual development in human males , 1980, Psychoneuroendocrinology.

[212]  C. Esser,et al.  Persistence of decreased T-helper cell function in industrial workers 20 years after exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. , 1996, Environmental health perspectives.

[213]  T. Lai,et al.  Cognitive development in Yucheng children. , 1994, Chemosphere.

[214]  S. Witkin,et al.  Detection of Chlamydia trachomatis in semen by the polymerase chain reaction in male members of infertile couples. , 1993, American journal of obstetrics and gynecology.

[215]  W. Kuber Testicular tumor and crytoptorchidism. , 1982, European Urology.

[216]  J. Gundersen,et al.  Ovarian Twin Pregnancy , 1980, Obstetrics and gynecology.

[217]  R. Williamson,et al.  Possible relationship between in utero diethylstilbestrol exposure and male fertility. , 1981, American journal of obstetrics and gynecology.

[218]  M. Moen Endometriosis in women at interval sterilization , 1987, Acta obstetricia et gynecologica Scandinavica.

[219]  R. Smialowicz,et al.  Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on humoral immunity and lymphocyte subpopulations: differences between mice and rats. , 1994, Toxicology and applied pharmacology.

[220]  A. Okey,et al.  Estrogenic and anti-estrogenic effects of DDT administered in the diet to immature female rats. , 1972, Canadian journal of physiology and pharmacology.

[221]  R. Peterson,et al.  Effects of gestational and lactational exposure to coplanar polychlorinated biphenyl (PCB) congeners or 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on thyroid hormone concentrations in weanling rats. , 1995, Toxicology letters.

[222]  C. Bastomsky Goitres in rats fed polychlorinated biphenyls. , 1977, Canadian journal of physiology and pharmacology.

[223]  R. Cooksey,et al.  Antithyroid and goitrogenic effects of coal-water extracts from iodine-sufficient goiter areas. , 1993, Thyroid : official journal of the American Thyroid Association.

[224]  K. Noller,et al.  Upper genital tract changes and infertility in diethylstilbestrol-exposed women. , 1986, American journal of obstetrics and gynecology.

[225]  T. Kalland,et al.  Natural killer cell activity and tumor susceptibility in female mice treated neonatally with diethylstilbestrol. , 1981, Cancer research.

[226]  M. Bosland Animal models for the study of prostate carcinogenesis , 1992, Journal of cellular biochemistry. Supplement.

[227]  K. Olie,et al.  Effects of pre- and postnatal exposure to chlorinated dioxins and furans on human neonatal thyroid hormone concentrations. , 1993, Environmental health perspectives.

[228]  H A Price,et al.  Lake Michigan fish consumption as a source of polychlorinated biphenyls in human cord serum, maternal serum, and milk. , 1983, American journal of public health.

[229]  B. Henderson,et al.  Descriptive epidemiology of testicular and prostatic cancer in Los Angeles. , 1979, British Journal of Cancer.

[230]  P. Bacchetti,et al.  Hormonal risk factors in testicular cancer. A case-control study. , 1986, American journal of epidemiology.

[231]  J. McLachlan,et al.  Progressive proliferative changes in the oviduct of mice following developmental exposure to diethylstilbestrol. , 1985, Teratogenesis, carcinogenesis, and mutagenesis.

[232]  Y. L. Guo,et al.  Early development of Yu-Cheng children born seven to twelve years after the Taiwan PCB outbreak. , 1994, Chemosphere.

[233]  N. Keiding,et al.  Evidence for decreasing quality of semen during past 50 years. , 1992 .

[234]  A. B. Barnes,et al.  Design and preliminary observations of National Cooperative Diethylstilbestrol Adenosis (DESAD) Project. , 1978, Obstetrics and gynecology.

[235]  G. Sutton Hormonal aspects of endometrial cancer. , 1990, Current opinion in obstetrics & gynecology.

[236]  M. Vessey,et al.  Epidemiology of endometriosis in women attending family planning clinics. , 1993, BMJ.

[237]  P. Vercellini,et al.  Deficient antiendometrium lymphocyte-mediated cytotoxicity in patients with endometriosis. , 1991, Fertility and sterility.

[238]  J. Sumpter,et al.  Environmentally persistent alkylphenolic compounds are estrogenic. , 1994, Endocrinology.

[239]  J. Becker,et al.  Endometriosis in Rhesus Monkeys (Macaca mulatta) Following Chronic Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin , 1993 .

[240]  M. Kuratsune Yusho, with reference to Yu-Cheng , 1989 .

[241]  L. Cousins,et al.  Reproductive outcome of women exposed to diethylstilboestrol in utero , 1980, Obstetrics and gynecology.

[242]  R. Myers,et al.  Endometriosis in rhesus monkeys. , 1970, American journal of obstetrics and gynecology.

[243]  W. Dmowski,et al.  Danazol but not gonadotropin-releasing hormone agonists suppresses autoantibodies in endometriosis. , 1988, Fertility and sterility.

[244]  P. Scott,et al.  Risk assessment of the mycotoxin zearalenone. , 1987, Regulatory toxicology and pharmacology : RTP.

[245]  T. Lai,et al.  Gender-related decrease in Raven's progressive matrices scores in children prenatally exposed to polychlorinated biphenyls and related contaminants , 1995, Bulletin of environmental contamination and toxicology.

[246]  A. Linos,et al.  Comments on occupational and environmental factors in the origin of non-Hodgkin's lymphoma. , 1992, Cancer research.

[247]  T. Kalland Alterations of antibody response in female mice after neonatal exposure to diethylstilbestrol. , 1980, Journal of immunology.

[248]  O. Heinonen Diethylstilbestrol in pregnancy. Frequency of exposure and usage patterns , 1973 .

[249]  E. Wynder,et al.  Comparative epidemiology of cancers of the colon, rectum, prostate and breast in Shanghai, China versus the United States. , 1991, International journal of epidemiology.

[250]  P. Ayotte,et al.  Inuit exposure to organochlorines through the aquatic food chain in arctic québec. , 1993, Environmental health perspectives.

[251]  W. Byne,et al.  Human sexual orientation. The biologic theories reappraised. , 1993, Archives of general psychiatry.

[252]  A. Ivy,et al.  Experimental intersexuality. The effects of estrogens on the antenatal sexual development of the rat , 1940 .

[253]  A. B. Barnes,et al.  Breast cancer in mothers given diethylstilbestrol in pregnancy. , 1984, The New England journal of medicine.

[254]  D. V. van Thiel,et al.  Assessment of the estrogenic activity of phytoestrogens isolated from bourbon and beer. , 1993, Alcoholism, clinical and experimental research.

[255]  A. Brouwer,et al.  Interference of polychlorinated biphenyls in thyroid hormone metabolism: possible neurotoxic consequences in fetal and neonatal rats. , 1992 .

[256]  K. Yoo,et al.  Independent protective effect of lactation against breast cancer: a case-control study in Japan. , 1992, American journal of epidemiology.

[257]  W. Grisham,et al.  Prenatal stress alters sexually dimorphic nuclei in the spinal cord of male rats , 1991, Brain Research.

[258]  S. Dehal,et al.  Cytochrome P450 catalyzed covalent binding of methoxychlor to rat hepatic, microsomal iodothyronine 5'-monodeiodinase, type I: does exposure to methoxychlor disrupt thyroid hormone metabolism? , 1995, Archives of biochemistry and biophysics.

[259]  W. Heinrichs,et al.  Effects of ddt homologs administered to female rats during the perinatal period. , 1975, Biology of the neonate.

[260]  D. V. van Thiel,et al.  Effects of in utero exposure to alcohol upon male rats. , 1985, Alcoholism, clinical and experimental research.

[261]  Robert W. Moore,et al.  In utero and lactational exposure of male rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin. 3. Effects on spermatogenesis and reproductive capability. , 1992, Toxicology and applied pharmacology.

[262]  F. Brown,,et al.  Antithyroid compound(s) produced by Escherichia coli: preliminary report. , 1974, The Journal of clinical endocrinology and metabolism.

[263]  J. Bitman,et al.  Estrogenic activity of DDT analogs and polychlorinated biphenyls. , 1970, Journal of agricultural and food chemistry.

[264]  N. Gleicher,et al.  Is endometriosis an autoimmune disease? , 1988, Obstetrics and gynecology.

[265]  P. Ayotte,et al.  Protective effect of breast feeding on breast cancer and body burden of carcinogenic organochlorines. , 1994, Journal of the National Cancer Institute.

[266]  C. Koopman‐Esseboom,et al.  Immunologic Effects of Background Prenatal and Postnatal Exposure to Dioxins and Polychlorinated Biphenyls in Dutch Infants , 1995, Pediatric Research.

[267]  R D Kimbrough,et al.  Polychlorinated biphenyls (PCBs) and human health: an update. , 1995, Critical reviews in toxicology.

[268]  Steven F. Arnold,et al.  Synergistic Activation of Estrogen Receptor with Combinations of Environmental Chemicals , 1996, Science.

[269]  N. Zvaifler,et al.  Alterations in immune responsiveness in women exposed to diethylstilbestrol in utero. , 1987, Fertility and sterility.

[270]  J. Sampson,et al.  Peritoneal endometriosis due to the menstrual dissemination of endometrial tissue into the peritoneal cavity , 1927 .

[271]  S. Micic,et al.  Seminal antisperm antibodies and genitourinary infection. , 1990, Urology.

[272]  M. Moen Why do women develop endometriosis and why is it diagnosed? , 1995, Human reproduction.

[273]  V. Aleandri,et al.  PCB and other organochlorine compounds in blood of women with or without miscarriage: a hypothesis of correlation. , 1989, Ecotoxicology and environmental safety.

[274]  D. Greydanus,et al.  Menstruation and its disorders in adolescence. , 1982, Current problems in pediatrics.

[275]  T. Mahmood,et al.  Prevalence and genesis of endometriosis. , 1991, Human reproduction.

[276]  J. Cabral,et al.  Effects of Long-Term Intake of DDT on Rats , 1982, Tumori.

[277]  J. Michalek,et al.  An Epidemiologic Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides. Extract Reproductive Outcomes Executive Summary introduction and Conclusions. , 1992 .

[278]  M. Bibbo,et al.  Association of diethylstilbestrol exposure in utero with cryptorchidism, testicular hypoplasia and semen abnormalities. , 1979, The Journal of urology.

[279]  Potency of Combined Estrogenic Pesticides , 1997, Science.

[280]  R. Duby,et al.  Uterotropic activity of DDT in rats and mink and its influence on reproduction in the rat. , 1971, Toxicology and applied pharmacology.

[281]  L. Tryphonas,et al.  A Pilot Study in Adult Rhesus Monkeys (M. mulatta) Treated with Aroclor 1254 for Two Years , 1986, Toxicologic pathology.

[282]  A. Guyton,et al.  Textbook of Medical Physiology , 1961 .

[283]  S. Robboy,et al.  Prenatal exposure to stilbestrol. A prospective comparison of exposed female offspring with unexposed controls. , 1975, The New England journal of medicine.

[284]  D G Hoel,et al.  Medical hypothesis: xenoestrogens as preventable causes of breast cancer. , 1993, Environmental health perspectives.

[285]  P. Troen,et al.  The testis in normal and infertile men , 1977 .

[286]  H. Adami,et al.  Increase in testicular cancer incidence in six European countries: a birth cohort phenomenon. , 1996, Journal of the National Cancer Institute.

[287]  C. Meuleman,et al.  Flow Cytometry Analysis of Lymphocyte Subpopulations in Peritoneal Fluid of Women With Endometriosis , 1994, American journal of reproductive immunology.

[288]  T. Key,et al.  Organochlorines in the environment and breast cancer , 1994, BMJ.

[289]  Y C Chen,et al.  Cognitive development of Yu-Cheng ("oil disease") children prenatally exposed to heat-degraded PCBs. , 1992, JAMA.

[290]  Abraham Brouwer,et al.  Effects of Dioxins and Polychlorinated Biphenyls on Thyroid Hormone Status of Pregnant Women and Their Infants , 1994, Pediatric Research.

[291]  A M Nomura,et al.  Migration patterns and breast cancer risk in Asian-American women. , 1993, Journal of the National Cancer Institute.

[292]  S. Schantz,et al.  Learning in monkeys exposed perinatally to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). , 1989, Neurotoxicology and teratology.

[293]  R. J. Gellert Uterotrophic activity of polychlorinated biphenyls (PCB) and induction of precocious reproductive aging in neonatally treated female rats. , 1978, Environmental research.

[294]  A. B. Barnes Menstrual history of young women exposed in utero to diethylstilbestrol. , 1979, Fertility and sterility.

[295]  A. Jacquemin-Sablon,et al.  Inhibitory effects of the tyrosine kinase inhibitor genistein on mammalian DNA topoisomerase II. , 1989, Cancer research.

[296]  C. Portier,et al.  Evaluation of chemicals with endocrine modulating activity in a yeast-based steroid hormone receptor gene transcription assay. , 1997, Toxicology and applied pharmacology.

[297]  R H Lapinski,et al.  Prevalence and natural history of cryptorchidism. , 1993, Pediatrics.

[298]  A. Pesatori,et al.  Cancer mortality of capacitor manufacturing workers. , 1987, American journal of industrial medicine.

[299]  J. Allen,et al.  Morphological changes in monkeys consuming a diet containing low levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin. , 1977, Food and cosmetics toxicology.

[300]  E. Levin,et al.  Behavioral evaluation of perinatal PCB exposure in rhesus monkeys: fixed-interval performance and reinforcement-omission. , 1986, Neurobehavioral toxicology and teratology.

[301]  J. Koeman,et al.  Different competition of thyroxine binding to transthyretin and thyroxine-binding globulin by hydroxy-PCBs, PCDDs and PCDFs. , 1994, European journal of pharmacology.

[302]  K. Hunt,et al.  Long-term effects of postmenopausal hormone therapy. , 1987, British journal of hospital medicine.

[303]  T. Derouen,et al.  Geologic implications in the distribution of endemic goiter in Colombia, South America. , 1978, International journal of epidemiology.

[304]  L. Ritter,et al.  Organochlorine Residues and Risk of Breast Cancer , 1995 .

[305]  Michael L. Gross,et al.  Chronic dietary intake of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) at 5 or 25 parts per trillion in the monkey: TCDD kinetics and dose-effect estimate of reproductive toxicity , 1989 .

[306]  L. Santi,et al.  Long‐term administration of ddt or phenobarbital‐na in wistar rats , 1977, International journal of cancer.

[307]  M. Hines Prenatal gonadal hormones and sex differences in human behavior. , 1982, Psychological bulletin.

[308]  L. Lipshultz,et al.  Have sperm counts been reduced 50 percent in 50 years? A statistical model revisited. , 1995, Fertility and sterility.

[309]  R. Hiatt,et al.  Breast cancer and serum organochlorines: a prospective study among white, black, and Asian women. , 1994, Journal of the National Cancer Institute.

[310]  T. Kalland,et al.  Long-term effects of neonatal estrogen treatment on mitogen responsiveness of mouse spleen lymphocytes. , 1979, Journal of the National Cancer Institute.

[311]  M. G. Ott,et al.  Morbidity follow up study of BASF employees exposed to 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD) after a 1953 chemical reactor incident. , 1994, Occupational and environmental medicine.

[312]  C. Lamartiniere,et al.  Xenoestrogens alter mammary gland differentiation and cell proliferation in the rat. , 1995, Environmental health perspectives.

[313]  T. Lai,et al.  Disordered behavior in the early-born Taiwan Yucheng children. , 1994, Chemosphere.

[314]  D. Brown,et al.  Mortality of workers exposed to polychlorinated biphenyls--an update. , 1987, Archives of environmental health.

[315]  P. Satyaswaroop,et al.  Autoantibodies associated with endometriosis: Can their detection predict presence of the disease? , 1991, Obstetrics and Gynecology.

[316]  C. Weinberg,et al.  Fertility in men exposed prenatally to diethylstilbestrol. , 1995 .

[317]  G. Bryan,et al.  Identification of carcinogenic tannin isolated from Bracken fern (Pteridium aquilinum). , 1976, Journal of the National Cancer Institute.

[318]  J. Sumpter,et al.  A variety of environmentally persistent chemicals, including some phthalate plasticizers, are weakly estrogenic. , 1995, Environmental health perspectives.

[319]  M. Pike,et al.  Estrogen exposure during gestation and risk of testicular cancer. , 1983, Journal of the National Cancer Institute.

[320]  R. M. Sharpe,et al.  Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract? , 1993, The Lancet.

[321]  J. Rajfer,et al.  Incidence of cryptorchidism. , 1982, The Urologic clinics of North America.

[322]  C. Densmore,et al.  Effects of coumestrol on estrogen receptor function and uterine growth in ovariectomized rats. , 1995, Environmental health perspectives.

[323]  R. Scully,et al.  Vaginal and Cervical Abnormalities After Exposure to Stilbestrol In Utero , 1972, Obstetrics and gynecology.

[324]  J. French,et al.  The incidence of thyroid disorders in the community: a twenty‐year follow‐up of the Whickham Survey , 1995, Clinical endocrinology.

[325]  J. H. Olson,et al.  Semen analyses in 1,283 men from the United States over a 25-year period: no decline in quality. , 1996, Fertility and sterility.

[326]  R. Kessler,et al.  Transplacental exposure to diethylstilbestrol in men. , 1979, Urology.

[327]  P C O'Brien,et al.  Males exposed in utero to diethylstilbestrol. , 1984, JAMA.

[328]  W. Stigelman,et al.  Goodman and Gilman's the Pharmacological Basis of Therapeutics , 1986 .

[329]  W. Thompson,et al.  Cancer risk among women exposed to exogenous estrogens during pregnancy. , 1984, Journal of the National Cancer Institute.

[330]  E. Wallach,et al.  Male fertility potential in terms of semen quality: a review of the past, a study of the present. , 1979, Fertility and sterility.

[331]  M. Booth,et al.  Epidemiology of endometriosis. , 1993, Journal of epidemiology and community health.

[332]  J. Koppe,et al.  Enzyme induction and alterations in thyroid hormone, vitamin A and K levels by TCDD in neonatal and maternal rats , 1990 .

[333]  L. Alfredsson,et al.  Etiologic fractions for physical work load, sports and overweight in the occurrence of coxarthrosis. , 1994, Scandinavian journal of work, environment & health.

[334]  H. Adlercreutz,et al.  Genistein, a dietary-derived inhibitor of in vitro angiogenesis. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[335]  H. Møller Clues to the aetiology of testicular germ cell tumours from descriptive epidemiology. , 1993, European urology.

[336]  S. Osser,et al.  Semen quality of smoking and non‐smoking men in infertile couples in a Swedish population , 1992, Acta obstetricia et gynecologica Scandinavica.

[337]  C. Bastomsky Effects of a polychlorinated biphenyl mixture (aroclor 1254) and DDT on biliary thyroxine excretion in rats. , 1974, Endocrinology.

[338]  S. Safe,et al.  Inhibition of 7,12-dimethylbenzanthracene-induced rat mammary tumor growth by 2,3,7,8-tetrachlorodibenzo-p-dioxin. , 1994, Cancer letters.

[339]  W. R. Swain,et al.  Effects of organochlorine chemicals on the reproductive outcome of humans who consumed contaminated Great Lakes fish: an epidemiologic consideration. , 1991, Journal of toxicology and environmental health.

[340]  J. McLachlan,et al.  Developmental oestrogenization and prostatic neoplasia. , 1990, International journal of andrology.

[341]  Y. Masuda Health status of Japanese and Taiwanese after exposure to contaminated rice oil. , 1985, Environmental health perspectives.

[342]  R. Kociba,et al.  2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD): results of a 13-week oral toxicity study in rats. , 1976, Toxicology and applied pharmacology.

[343]  K. Korach,et al.  Printed in U.S.A. Copyright © 1997 by The Endocrine Society Estrogenic Activity of a Dieldrin/Toxaphene Mixture in the Mouse Uterus, MCF-7 Human Breast Cancer Cells, and Yeast-Based Estrogen Receptor Assays: No Apparent Synergism* , 2022 .

[344]  L. Meserve,et al.  Thyroxine normalizes polychlorinated biphenyl (PCB) dose-related depression of choline acetyltransferase (ChAT) activity in hippocampus and basal forebrain of 15-day-old rats. , 1994, Toxicology.

[345]  L. Johnson,et al.  Effects of developmental exposure to indole-3-carbinol or 2,3,7,8-tetrachlorodibenzo-p-dioxin on reproductive potential of male rat offspring. , 1996, Toxicology and applied pharmacology.

[346]  Potency of a complex mixture of polychlorinated dibenzo-p-dioxin, dibenzofuran, and biphenyl congeners compared to 2,3,7,8-tetrachlorodibenzo-p-dioxin in causing fish early life stage mortality. , 1996 .

[347]  A. Schecter,et al.  Comparison of PCDDs and PCDFs in the tissues of Yusho patients with those from the general population in Japan and China , 1987 .

[348]  J. Olsen Is human fecundity declining--and does occupational exposures play a role in such a decline if it exists? , 1994, Scandinavian journal of work, environment & health.

[349]  D. Ryan,et al.  Naturally-Occurring Estrogens in Plant Foodstuffs - A Review. , 1979, Journal of food protection.

[350]  D. Bloom,et al.  The undescended testis. Theory and management. , 1995, The Urologic clinics of North America.

[351]  H. Bern,et al.  Prolonged vaginal cornification and other changes in mice treated neonatally with coumestrol, a plant estrogen. , 1985, Journal of toxicology and environmental health.

[352]  B. Gladen,et al.  Does early exposure to maternal smoking affect future fertility in adult males? , 1992, Reproductive toxicology.

[353]  W. James Secular Trend in Reported Sperm Counts , 2009, Andrologia.

[354]  R. Newbold Gender-related behavior in women exposed prenatally to diethylstilbestrol. , 1993, Environmental health perspectives.

[355]  W. Porter,et al.  Groundwater pesticides: interactive effects of low concentrations of carbamates aldicarb and methomyl and the triazine metribuzin on thyroxine and somatotropin levels in white rats. , 1993, Journal of toxicology and environmental health.

[356]  H. Tryphonas,et al.  Comparative aspects of Aroclor® 1254 toxicity in adult cynomolgus and rhesus monkeys: A pilot study , 1986, Archives of environmental contamination and toxicology.

[357]  J. Reinisch,et al.  Hormonal contributions to sexually dimorphic behavioral development in humans , 1991, Psychoneuroendocrinology.

[358]  J. Ranstam,et al.  Depressed semen quality: a study over two decades. , 1984, Archives of andrology.

[359]  D. Thomas,et al.  Cancer in first and second generation Americans. , 1987, Cancer research.

[360]  J. Jacobson,et al.  Effects of in utero exposure to polychlorinated biphenyls and related contaminants on cognitive functioning in young children. , 1990, The Journal of pediatrics.

[361]  M. Pike,et al.  The role of oestrogens and progestagens in the epidemiology and prevention of breast cancer. , 1988, European journal of cancer & clinical oncology.

[362]  C. Ford,et al.  Natural killer cells in in utero diethylstilbesterol-exposed patients. , 1983, Gynecologic oncology.

[363]  B. Gladen,et al.  Effects of perinatal polychlorinated biphenyls and dichlorodiphenyl dichloroethene on later development. , 1991, The Journal of pediatrics.

[364]  D. Armant,et al.  The influence of chamber characteristics on the reliability of sperm concentration and movement measurements obtained by manual and videomicrographic analysis. , 1990, Fertility and sterility.

[365]  M. Hull,et al.  1 Is endometriosis a disease , 1993 .

[366]  V. Devita,et al.  Cancer : Principles and Practice of Oncology , 1982 .

[367]  B S Ahluwalia,et al.  The effect of delta 9-tetrahydrocannabinol in utero exposure on rat offspring fertility and ventral prostate gland morphology. , 1985, Journal of andrology.

[368]  C. Bastomsky Enhanced thyroxine metabolism and high uptake goiters in rats after a single dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin. , 1977, Endocrinology.

[369]  B. Gladen,et al.  Neonatal effects of transplacental exposure to PCBs and DDE. , 1986, The Journal of pediatrics.

[370]  R. Stillman In utero exposure to diethylstilbestrol: adverse effects on the reproductive tract and reproductive performance and male and female offspring. , 1982, American journal of obstetrics and gynecology.

[371]  H. Meyer-Bahlburg,et al.  Prenatal estrogens and the development of homosexual orientation. , 1995 .

[372]  L. Gray,et al.  Developmental effects of an environmental antiandrogen: the fungicide vinclozolin alters sex differentiation of the male rat. , 1994, Toxicology and applied pharmacology.

[373]  P. Reijnders Toxicokinetics of chlorobiphenyls and associated physiological responses in marine mammals, with particular reference to their potential for ecotoxicological risk assessment. , 1994, The Science of the total environment.

[374]  T. Brazelton,et al.  Neonatal Behavioral Assessment Scale , 1973 .

[375]  E. Gaitan,et al.  Goitrogens in food and water. , 1990, Annual review of nutrition.

[376]  L. Melton,et al.  Increased occurrence of autoimmune disease among women exposed in utero to diethylstilbestrol. , 1988, Fertility and sterility.

[377]  K. Grigor,et al.  Regional and geographical variations in infertility: effects of environmental, cultural, and socioeconomic factors. , 1993, Environmental health perspectives.

[378]  W. Thompson,et al.  Maternal Age at Birth and Risk of Breast Cancer in Daughters , 1990, Epidemiology.

[379]  H. Tryphonas,et al.  Toxicological consequences of Aroclor 1254 ingestion by female rhesus (Macaca mulatta) monkeys. Part 1B. Prebreeding phase: clinical and analytical laboratory findings. , 1993, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[380]  H. Tryphonas Immunotoxicity of polychlorinated biphenyls: present status and future considerations. , 1994, Experimental and clinical immunogenetics.

[381]  D. Sager Effect of postnatal exposure to polychlorinated biphenyls on adult male reproductive function. , 1983, Environmental research.

[382]  K. Noller,et al.  Upper genital tract abnormalities and pregnancy outcome in diethylstilbestrol-exposed progeny. , 1984, American journal of obstetrics and gynecology.

[383]  H. Tilson,et al.  The concern for developmental neurotoxicology: is it justified and what is being done about it? , 1995, Environmental health perspectives.

[384]  A. Blair,et al.  Dichlorodiphenyltrichloroethane serum levels and breast cancer risk: a case-control study from Mexico. , 1997, Cancer research.

[385]  R. Newbold Cellular and molecular effects of developmental exposure to diethylstilbestrol: implications for other environmental estrogens. , 1995, Environmental health perspectives.

[386]  J. Jacobson,et al.  The effect of intrauterine PCB exposure on visual recognition memory. , 1985, Child development.

[387]  J. Godbold,et al.  Maternal and Neonatal Risk Factors for Cryptorchidism , 1995, Epidemiology.

[388]  H. Adlercreutz,et al.  Diet and breast cancer. , 1992, Acta oncologica.

[389]  M. Waer,et al.  Lymphokine-activated killer activity in women with endometriosis. , 1994, Gynecologic and obstetric investigation.

[390]  F. Azizi,et al.  Reproductive and gynecologic surgical experience in diethylstilbestrol-exposed daughters. , 1981, American journal of obstetrics and gynecology.

[391]  J. Jacobson,et al.  Prenatal exposure to polychlorinated biphenyls: effects on birth size and gestational age. , 1984, The Journal of pediatrics.

[392]  N Dubin,et al.  Blood levels of organochlorine residues and risk of breast cancer. , 1993, Journal of the National Cancer Institute.

[393]  D. Shutt The effects of plant oestrogens on animal reproduction. , 1976, Endeavour.

[394]  B A Miller,et al.  The role of increasing detection in the rising incidence of prostate cancer. , 1995, JAMA.

[395]  J. Simpson,et al.  Heritable aspects of endometriosis. I. Genetic studies. , 1980, American journal of obstetrics and gynecology.