Antitrypsin and chronic obstructive pulmonary disease among Japanese-American men.

A total of 161 patients with chronic obstructive pulmonary disease (COPD) plus 100 control subjects (identified during a study of heart disease in 6,860 Japanese-American men aged 52 to 75 years who were residing in Hawaii) were analyzed for phenotype in search of the antitrypsin gene Z, which has been shown to be associated with pulmonary emphysema in other racial groups. No carriers of the Z gene were found, and the question of whether the rarity or absence of this gene relates to a low frequency of COPD among Japanese-Americans is reviewed.

[1]  J. Lieberman,et al.  Intermediate alpha1-antitrypsin deficiency resulting from a null gene (M-phenotype). , 1976, Chest.

[2]  B. Ferris,et al.  Chronic nonspecific respiratory disease in Berlin, New Hampshire, 1967 to 1973. A further follow-up study. , 1976, American Review of Respiratory Disease.

[3]  J. Pierce,et al.  Antitrypsin phenotypes in St. Louis. , 1975, JAMA.

[4]  S. Syme,et al.  Epidemiologic studies of coronary heart disease and stroke in Japanese men living in Japan, Hawaii and California: demographic, physical, dietary and biochemical characteristics. , 1974, Journal of chronic diseases.

[5]  L. F. Black,et al.  Alpha1-antitrypsin and its deficiency. , 1974, The American review of respiratory disease.

[6]  B. Ferris,et al.  Chronic nonspecific respiratory disease in Berlin, New Hampshire, 1961 to 1967. A follow-up study. , 2015, The American review of respiratory disease.

[7]  R. Talamo,et al.  α1-Antitrypsin Deficiency: A Variant with No Detectable α1-Antitrypsin , 1973, Science.

[8]  H. Kato,et al.  Epidemiologic studies of coronary heart disease and stroke in Japanese men living in Japan, Hawaii and California. , 1973, American journal of epidemiology.

[9]  K. Nomiyama,et al.  Prevalence of 1-antitrypsin deficiency in Japan. , 1971, Bulletin of the World Health Organization.

[10]  R. Worth,et al.  Ascertainment of men of Japanese ancestry in Hawaii through World War II Selective Service registration. , 1970, Journal of chronic diseases.

[11]  S. Harada,et al.  Electrophoretic Variation of Human Serum α1-antitrypsin in Japan , 1970 .

[12]  C. Laurell,et al.  The polymorphism of “prealbumins” and α1-antitrypsin in human sera , 1967 .

[13]  L. Reid.  The pathology of emphysema. , 1966, Postgraduate medicine.

[14]  E. Gaensler,et al.  Evaluation of respiratory impairment. , 1966, Archives of environmental health.

[15]  M. Fagerhol,et al.  Serum Prealbumin: Polymorphism in Man , 1965, Science.

[16]  S. Eriksson.  Studies in alpha 1-antitrypsin deficiency. , 1965, Acta medica Scandinavica. Supplementum.

[17]  S. Eriksson,et al.  PULMONARY EMPHYSEMA AND ALPHA1-ANTITRYPSIN DEFICIENCY. , 2009, Acta medica Scandinavica.

[18]  C. Laurell,et al.  The Electrophoretic α;1-Globulin Pattern of Serum in α;1-Antitrypsin Deficiency , 1963 .

[19]  N. Oswald.  Recent Trends in Chronic Bronchitis , 1958 .