EM-TV reconstruction algorithm for pinhole-type fluorescent X-ray computed tomography

We have so far developed a fluorescent X-ray computed tomography (FXCT) with a two-dimensional detector based on the pinhole effect for imaging non-radioactive agent distribution in a small animal. However, it takes several hours to acquire a series of projections required for an image with quality sufficient for biological observation. To overcome the difficulty, we realize a high-speed imaging by reducing the number of projections while keeping the image quality using an EM-TV (Expectation Maximization and Total Variation) algorithm, which is a kind of compressed sensing technique. We demonstrate the efficacy by simulation data and actual data obtained in the imaging experiment performed at beamline AR-NE7A, KEK, Tsukuba.

[1]  Luminita A. Vese,et al.  Expectation maximization and total variation-based model for computed tomography reconstruction from undersampled data , 2011, Medical Imaging.

[2]  R. Gonsalves,et al.  Fluorescent computer tomography: a model for correction of X-ray absorption , 1991 .

[3]  Tetsuya Yuasa,et al.  Visualization of age-dependent myocardial metabolic impairment in cardiomyopathic model hamster obtained by fluorescent X-ray computed tomography using I-127 BMIPP. , 2008, Journal of synchrotron radiation.

[4]  Tetsuya Yuasa,et al.  Sheet-beam geometry for in vivo fluorescent x-ray computed tomography: proof-of-concept experiment in molecular imaging. , 2008, Optics letters.

[5]  Tetsuya Yuasa,et al.  Fluorescent x-ray computed tomography using the pinhole effect for biomedical applications , 2013 .

[6]  F. Beekman,et al.  U-SPECT-II: An Ultra-High-Resolution Device for Molecular Small-Animal Imaging , 2009, Journal of Nuclear Medicine.

[7]  C. Schroer Reconstructing x-ray fluorescence microtomograms , 2001 .

[8]  Martin Burger,et al.  Bregman-EM-TV Methods with Application to Optical Nanoscopy , 2009, SSVM.

[9]  L. Rudin,et al.  Nonlinear total variation based noise removal algorithms , 1992 .

[10]  Tetsuya Yuasa,et al.  X-ray fluorescent CT imaging of cerebral uptake of stable-iodine perfusion agent iodoamphetamine analog IMP in mice. , 2009, Journal of synchrotron radiation.

[11]  Tetsuya Yuasa,et al.  Reconstruction method for fluorescent X-ray computed tomography by least-squares method using singular value decomposition , 1997 .

[12]  Jason Cong,et al.  A Hybrid Architecture for Compressive Sensing 3-D CT Reconstruction , 2012, IEEE Journal on Emerging and Selected Topics in Circuits and Systems.