Fish consumption is a safe solution to increase the intake of long-chain n-3 fatty acids

Abstract Objectives Dietary intake of long-chain (LC) n-3 PUFA in developed countries is low compared with recommendations. Fish is naturally rich in LC n-3 PUFA, but is also a dietary source of heavy metals and organic pollutants. We investigated whether the recommendation for LC n-3 PUFA could be reached through fish consumption, without exceeding the provisional tolerable weekly intake of methylmercury (MeHg) and the tolerable weekly intake (TWI) of dioxin-like compounds. Also, the contribution of margarines enriched with LC n-3 PUFA was assessed. Design Published nutrient and contaminant data were used in a probabilistic model to calculate the simultaneous nutrient and contaminant intake for different fish consumption scenarios. Results The Belgian recommendation for EPA + DHA (0·3 % of total energy intake) can be reached by consuming fatty fish a minimum of twice a week, or by varying between lean and fatty fish a minimum of three times a week. At this fish consumption level, MeHg intake is not an issue of toxicological concern. The intake of dioxin-like compounds approximates the TWI when consuming fatty fish more than twice a week, this being a potential toxicological risk because other food items also contribute to the weekly intake of dioxin-like compounds. Use of margarine enriched with LC n-3 PUFA can help to increase LC n-3 intake, on average by 159 mg/d. Conclusions Combination of regular fish consumption (twice a week) with important contribution of fatty fish species, in combination with regular consumption of margarine enriched with EPA + DHA, can be advised to achieve the recommendation for LC n-3 intake.

[1]  M. Kornitzer,et al.  The Belgian Interuniversity Research on Nutrition and Health (B.I.R.N.H.): general introduction. For the B.I.R.N.H. Study Group. , 1989, Acta cardiologica.

[2]  C Matthys,et al.  Importance of seafood as nutrient source in the diet of Belgian adolescents. , 2007, Journal of human nutrition and dietetics : the official journal of the British Dietetic Association.

[3]  A. Glynn,et al.  Dietary intake estimations of organohalogen contaminants (dioxins, PCB, PBDE and chlorinated pesticides, e.g. DDT) based on Swedish market basket data. , 2006, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[4]  Mia Bellemans,et al.  Maten en gewichten: handleiding voor gestandaardiseerde kwantificering van voedingsmiddelen in België , 2002 .

[5]  Wim Verbeke,et al.  Exploring the relationship between convenience and fish consumption: A cross-cultural study , 2007, Appetite.

[6]  N. Skovgaard Safety evaluation of certain food additives and contaminants , 2000 .

[7]  J. Sontrop,et al.  Omega-3 polyunsaturated fatty acids and depression: a review of the evidence and a methodological critique. , 2006, Preventive medicine.

[8]  A. Kinney Metabolic engineering in plants for human health and nutrition. , 2006, Current opinion in biotechnology.

[9]  C. Levenson,et al.  Too much of a good thing? Update on fish consumption and mercury exposure. , 2006, Nutrition reviews.

[10]  Lawrence J Appel,et al.  Omega-3 Fatty Acids and Cardiovascular Disease: New Recommendations From the American Heart Association , 2003, Arteriosclerosis, thrombosis, and vascular biology.

[11]  Gert B. M. Mensink,et al.  Dietary intake and sources of long-chain n-3 PUFAs in German adults , 2006, European Journal of Clinical Nutrition.

[12]  D. Carpenter,et al.  Risk-Based Consumption Advice for Farmed Atlantic and Wild Pacific Salmon Contaminated with Dioxins and Dioxin-like Compounds , 2005, Environmental health perspectives.

[13]  David E Newby,et al.  Omega 3 fatty acids and cardiovascular disease-- fishing for a natural treatment , 2003 .

[14]  T. Vartiainen,et al.  PCDD/Fs and PCBs in Baltic herring during the 1990s. , 2003, Chemosphere.

[15]  V. Nelen,et al.  Dietary exposure to dioxin-like compounds in three age groups: results from the Flemish environment and health study. , 2008, Chemosphere.

[16]  D. Carpenter,et al.  Consumption advisories for salmon based on risk of cancer and noncancer health effects. , 2006, Environmental research.

[17]  K. S. Sidhu Health benefits and potential risks related to consumption of fish or fish oil. , 2003, Regulatory toxicology and pharmacology : RTP.

[18]  N. Efsa-Q,et al.  Opinion of the Scientific Panel on Contaminants in the Food Chain on a request from the Commission related to mercury and methylmercury in food ( Request N ° , 2004 .

[19]  J. Camp,et al.  n-6 and n-3 PUFA intakes of pre-school children in Flanders, Belgium. , 2007, The British journal of nutrition.

[20]  J. Camp,et al.  Simulated changes in fatty acid intake in humans through n-3 fatty acid enrichment of foods from animal origin , 2007 .

[21]  S. De Henauw,et al.  How to Use Secondary Data on Seafood Contamination for Probabilistic Exposure Assessment Purposes? Main Problems and Potential Solutions , 2007 .

[22]  P. Kris-Etherton,et al.  Dietary omega-3 fatty acid intake and cardiovascular risk. , 2006, The American journal of cardiology.

[23]  Lawrence J Appel,et al.  Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. , 2002, Arteriosclerosis, thrombosis, and vascular biology.

[24]  R. Ishaq,et al.  Biomagnification of PBDEs and PCBs in food webs from the Baltic Sea and the northern Atlantic Ocean. , 2006, The Science of the total environment.

[25]  R Hoogerbrugge,et al.  Dioxins, dioxin-like PCBs and non-dioxin-like PCBs in foodstuffs: occurrence and dietary intake in The Netherlands. , 2004, Toxicology letters.

[26]  Joshua T. Cohen,et al.  A quantitative risk-benefit analysis of changes in population fish consumption. , 2005, American journal of preventive medicine.

[27]  Davide Bertelli,et al.  Mercury and Selenium Content in Selected Seafood , 2001 .

[28]  J. L. Willems,et al.  Probabilistic intake assessment and body burden estimation of dioxin-like substances in background conditions and during a short food contamination episode , 2002, Food additives and contaminants.

[29]  J. Camp,et al.  Development of a nutrient database and distributions for use in a probabilistic risk-benefit analysis of human seafood consumption , 2007 .

[30]  E M Faustman,et al.  Use of Quality‐Adjusted Life Year Weights with Dose‐Response Models for Public Health Decisions: A Case Study of the Risks and Benefits of Fish Consumption , 2000, Risk analysis : an official publication of the Society for Risk Analysis.

[31]  T. Vartiainen,et al.  Market basket study on dietary intake of PCDD/Fs, PCBs, and PBDEs in Finland. , 2004, Environment international.

[32]  David O Carpenter,et al.  Quantitative analysis of the benefits and risks of consuming farmed and wild salmon. , 2005, The Journal of nutrition.

[33]  C. Ruxton,et al.  The health benefits of omega-3 polyunsaturated fatty acids: a review of the evidence. , 2004, Journal of human nutrition and dietetics : the official journal of the British Dietetic Association.

[34]  G. Migliorati,et al.  Human exposure to dioxins through diet in Italy. , 2005, Chemosphere.

[35]  M. Storelli,et al.  Polychlorinated biphenyls in seafood: contamination levels and human dietary exposure , 2003 .

[36]  J. Camp,et al.  Dietary intakes and food sources of fatty acids for Belgian women, focused on n-6 and n-3 polyunsaturated fatty acids , 2006, Lipids.

[37]  R. Deckelbaum,et al.  n-3 Fatty acids and cardiovascular disease: navigating toward recommendations. , 2006, The American journal of clinical nutrition.

[38]  M. Kornitzer,et al.  Regional differences in dietary habits, coronary risk factors and mortality rates in Belgium: Design and methodology , 1984 .

[39]  Ethan M Balk,et al.  n-3 Fatty acids from fish or fish-oil supplements, but not alpha-linolenic acid, benefit cardiovascular disease outcomes in primary- and secondary-prevention studies: a systematic review. , 2006, The American journal of clinical nutrition.

[40]  Sir,et al.  Our food, our health - Healthy diet and safe food in the Netherlands , 2006 .

[41]  R. Fanelli,et al.  Current dietary exposure to polychlorodibenzo-p-dioxins, polychlorodibenzofurans, and dioxin-like polychlorobiphenyls in Italy. , 2006, Molecular nutrition & food research.

[42]  Tricia L Psota,et al.  n-3 fatty acid dietary recommendations and food sources to achieve essentiality and cardiovascular benefits. , 2006, The American journal of clinical nutrition.