The extracellular matrix and blood vessel formation: not just a scaffold

•  Introduction •  ECM: composition and structure ‐  Collagen ‐  Laminin ‐  Fibronectin ‐  Elastin ‐  Nidogen ‐  Glycosaminoglycans ‐  Perlecan ‐  Syndecans ‐  Receptors for ECM molecules •  Evaluation of ECM molecules and their modulators in vessel formation ‐  Determination of essential ECM components of vessel formation ‐  Collagen‐I and laminins are important for vessel structural integrity and provide contrasting signals in angiogenesis ‐  The function of collagens in the blood vessel basement membrane ‐  Laminin α4 is a key molecule in basement membrane assembly, microvessel stability and maturation ‐  Fibronectin is essential for vascular development ‐  Perlecan and syndecans modulate growth factors in angiogenesis ‐  Fragments of ECM proteins regulate angiogenic processes ‐  Proteins involved in signalling through ECM molecules ‐  Thrombospondins ‐  CCN proteins •  ECM signalling in vessel formation: what next?

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