Regulation of pancreatic β-cell growth and survival by the serine/threonine protein kinase Akt1/PKBα

[1]  R. Burcelin,et al.  Hypoinsulinaemia, glucose intolerance and diminished β-cell size in S6K1-deficient mice , 2000, Nature.

[2]  P. Kang,et al.  The conserved phosphoinositide 3‐kinase pathway determines heart size in mice , 2000, The EMBO journal.

[3]  B. Edgar From small flies come big discoveries about size control , 1999, Nature Cell Biology.

[4]  E. Wilder,et al.  Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB , 1999, Nature Cell Biology.

[5]  E. Hafen,et al.  Drosophila S6 kinase: a regulator of cell size. , 1999, Science.

[6]  T. P. Neufeld,et al.  Regulation of imaginal disc cell size, cell number and organ size by Drosophila class IA phosphoinositide 3-kinase and its adaptor , 1999, Current Biology.

[7]  E. Ostrander,et al.  Let sleeping dogs lie? , 1999, Nature Genetics.

[8]  M. Birnbaum,et al.  Differentiation-dependent Suppression of Platelet-derived Growth Factor Signaling in Cultured Adipocytes* , 1999, The Journal of Biological Chemistry.

[9]  E. Hafen,et al.  Autonomous Control of Cell and Organ Size by CHICO, a Drosophila Homolog of Vertebrate IRS1–4 , 1999, Cell.

[10]  C. Kahn,et al.  Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes , 1999, Cell.

[11]  Stefano Fumagalli,et al.  Disruption of the p70s6k/p85s6k gene reveals a small mouse phenotype and a new functional S6 kinase , 1998, The EMBO journal.

[12]  D. Mauricio,et al.  Apoptosis and the pathogenesis of IDDM: a question of life and death. , 1998, Diabetes.

[13]  J. Woodgett,et al.  Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation. , 1998, The Biochemical journal.

[14]  G. Ruvkun,et al.  Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor. , 1998, Genes & development.

[15]  R. Roth,et al.  Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[16]  P. Froguel,et al.  Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice. , 1998, The Journal of clinical investigation.

[17]  J. Woodgett,et al.  Genetic analysis of protein kinase B (AKT) in Drosophila , 1998, Current Biology.

[18]  K. Polonsky,et al.  Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat. , 1998, Diabetes.

[19]  G. Shulman,et al.  Disruption of IRS-2 causes type 2 diabetes in mice , 1998, Nature.

[20]  D. Le Roith,et al.  Seminars in medicine of the Beth Israel Deaconess Medical Center. Insulin-like growth factors. , 1997 .

[21]  P. Cohen,et al.  Mechanism of activation of protein kinase B by insulin and IGF‐1. , 1996, The EMBO journal.

[22]  R. Roth,et al.  Akt, a Pleckstrin Homology Domain Containing Kinase, Is Activated Primarily by Phosphorylation* , 1996, The Journal of Biological Chemistry.

[23]  R. Garofalo,et al.  The Drosophila insulin receptor is required for normal growth. , 1996, Endocrinology.

[24]  D. Allan,et al.  BETA‐CELL APOPTOSIS IS RESPONSIBLE FOR THE DEVELOPMENT OF IDDM IN THE MULTIPLE LOW‐DOSE STREPTOZOTOCIN MODEL , 1996, The Journal of pathology.

[25]  R. Roth,et al.  Insulin stimulates the kinase activity of RAC‐PK, a pleckstrin homology domain containing ser/thr kinase. , 1995, The EMBO journal.

[26]  S. Bonner-Weir,et al.  Dynamics of β-cell Mass in the Growing Rat Pancreas: Estimation With a Simple Mathematical Model , 1995, Diabetes.

[27]  S. Bonner-Weir,et al.  Beta cell mass and growth after syngeneic islet cell transplantation in normal and streptozocin diabetic C57BL/6 mice. , 1993, The Journal of clinical investigation.

[28]  D. Hanahan,et al.  Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. , 1985, Nature.

[29]  A. Rossini,et al.  Streptozotocin-induced pancreatic insulitis: new model of diabetes mellitus. , 1976, Science.

[30]  H. Towery,et al.  Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling. , 1999, Nature genetics.

[31]  D. Le Roith Seminars in medicine of the Beth Israel Deaconess Medical Center. Insulin-like growth factors. , 1997, The New England journal of medicine.

[32]  S. Heyner,et al.  Biological actions of IGFs in mammalian development. , 1994, BioEssays : news and reviews in molecular, cellular and developmental biology.