The basis of toxicity testing

Introduction Preliminary Considerations Introduction The Agent Being Tested The Vehicle Routes of Administration Species Pharmacokinetics/Toxicokinetics Biotransformation Diet Endpoints of Toxicity Animal Numbers Acute Toxicity Studies Purpose and Objectives Study Design Interpretation of Data Utility of the LD50 Studies Dermal Toxicity Studies Ocular Toxicity Studies Utility of Alternative Studies Conclusions Subchronic and Chronic Studies Introduction Experimental Design Evaluation of Results Carcinogenicity Studies Reproductive Toxicology Introduction Male Reproductive Toxicity Female Reproductive Toxicity Preimplantation Studies Teratogenicity Embryo Culture Harmonization Screening Tests Mutagenesis Carcinogenesis Introduction Mutagenesis Mutagenicity Testing with Prokaryotic Cell Systems Mutagenicity Testing with Eukaryotic Cell Systems In Vitro Mutagenicity Testing with Eukaryotic Cells In Vivo The Impossibility A Test for All Mutagens Carcinogenicity Testing Strategies for Limited Bioassays