Frequency-dependent complex modulus of the uterus: preliminary results

The frequency-dependent complex moduli of human uterine tissue have been characterized. Quantification of the modulus is required for developing uterine ultrasound elastography as a viable imaging modality for diagnosing and monitoring causes for abnormal uterine bleeding and enlargement, as well assessing the integrity of uterine and cervical tissue. The complex modulus was measured in samples from hysterectomies of 24 patients ranging in age from 31 to 79 years. Measurements were done under small compressions of either 1 or 2%, at low pre-compression values (either 1 or 2%), and over a frequency range of 0.1–100 Hz. Modulus values of cervical tissue monotonically increased from approximately 30–90 kPa over the frequency range. Normal uterine tissue possessed modulus values over the same range, while leiomyomas, or uterine fibroids, exhibited values ranging from approximately 60–220 kPa.

[1]  K. Matsuzaki,et al.  Pathologies of the uterine endometrial cavity: usual and unusual manifestations and pitfalls on magnetic resonance imaging , 2005, European Radiology.

[2]  Kai-Nan An,et al.  Dynamic mechanical properties of agarose gels modeled by a fractional derivative model. , 2004, Journal of biomechanical engineering.

[3]  Tomy Varghese,et al.  Viscoelastic characterization of in vitro canine tissue. , 2004, Physics in medicine and biology.

[4]  B. Mclucas,et al.  Adenomyosis: MRI of the uterus treated with uterine artery embolization. , 2004, AJR. American journal of roentgenology.

[5]  T. Winter,et al.  Saline Infusion Sonohysterography , 2004, Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.

[6]  S. Ascher,et al.  Adenomyosis: MRI of the uterus treated with uterine artery embolization. , 2003, AJR. American journal of roentgenology.

[7]  S. Ascher,et al.  Benign myometrial conditions: leiomyomas and adenomyosis. , 2003, Topics in magnetic resonance imaging : TMRI.

[8]  T. Dubinsky,et al.  Ultrasonographic evaluation of the endometrium in postmenopausal vaginal bleeding. , 2003, Radiologic clinics of North America.

[9]  S. Laifer-Narin,et al.  US of abnormal uterine bleeding. , 2003, Radiographics : a review publication of the Radiological Society of North America, Inc.

[10]  C. S. Spalding,et al.  In vivo real-time freehand palpation imaging. , 2003, Ultrasound in medicine & biology.

[11]  D. Timmerman,et al.  Uterine adenomyosis in the infertility clinic. , 2003, Human reproduction update.

[12]  L. S. Taylor,et al.  Preliminary Results of Cyclic Uniaxial Compression of Bovine Liver , 2003 .

[13]  J Ophir,et al.  Elastographic Imaging Using Staggered Strain Estimates , 2002, Ultrasonic imaging.

[14]  Yanning Zhu,et al.  A Modified Block Matching Method for Real-Time Freehand Strain Imaging , 2002, Ultrasonic imaging.

[15]  Lynne E. Bilston,et al.  Viscoelastic properties of pig kidney in shear, experimental results and modelling , 2002 .

[16]  DYNAMIC MECHANICAL PROPERTIES OF AGAROSE GEL BY A FRACTIONAL DERIVATIVE MODEL , 2002 .

[17]  Kevin J. Parker,et al.  A Kelvin-Voight Fractional Derivative Model for Viscoelastic Characterization of Liver Tissue , 2002 .

[18]  E. Darai,et al.  Ultrasonography compared with magnetic resonance imaging for the diagnosis of adenomyosis: correlation with histopathology. , 2001, Human reproduction.

[19]  L. S. Taylor,et al.  Viscoelastic effects in sonoelastography: impact on tumor detectability , 2001, 2001 IEEE Ultrasonics Symposium. Proceedings. An International Symposium (Cat. No.01CH37263).

[20]  K. Bhatia,et al.  Ultrasonic characteristics of leiomyoma uteri in vitro. , 2001, Ultrasound in medicine & biology.

[21]  R. Martin,et al.  Attenuation coefficient and sound speed in human myometrium and uterine fibroid tumors. , 2001, Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.

[22]  P. Doubilet,et al.  US evaluation of the uterus in patients with postmenopausal bleeding: A positive effect on diagnostic decision making. , 2000, Radiology.

[23]  E. Caoili,et al.  Refractory shadowing from pelvic masses on sonography: a useful diagnostic sign for uterine leiomyomas. , 2000, AJR. American journal of roentgenology.

[24]  C. Reinhold,et al.  Uterine adenomyosis: endovaginal US and MR imaging features with histopathologic correlation. , 1999, Radiographics : a review publication of the Radiological Society of North America, Inc.

[25]  C. Wood,et al.  Surgical and medical treatment of adenomyosis. , 1998, Human reproduction update.

[26]  B. Garra,et al.  Elastography of breast lesions: initial clinical results. , 1997, Radiology.

[27]  F. Kallel,et al.  Elastography: A systems approach , 1997, Int. J. Imaging Syst. Technol..

[28]  C. Reinhold,et al.  Diffuse adenomyosis: comparison of endovaginal US and MR imaging with histopathologic correlation. , 1996, Radiology.

[29]  J Ophir,et al.  Fundamental limitations on the contrast-transfer efficiency in elastography: an analytic study. , 1996, Ultrasound in medicine & biology.

[30]  B. Carroll,et al.  Acoustic shadowing from uterine leiomyomas: sonographic-pathologic correlation. , 1995, Radiology.

[31]  A. Barabasi,et al.  Lung tissue viscoelasticity: a mathematical framework and its molecular basis. , 1994, Journal of applied physiology.

[32]  J. Spencer,et al.  Ultrasonography compared with intravenous urography in the investigation of adults with haematuria. , 1990, BMJ.

[33]  R. Christensen.  Theory of viscoelasticity : an introduction , 1971 .

[34]  R. Musset.  [Uterine adenomyosis]. , 1968, Les Cahiers du College de medecine des hopitaux de Paris.