Introduction to computational genomics - a case studies approach

Prologue (in praise of cells) 1. The first look at a genome (sequence statistics) 2. All the sequence's men (gene finding) 3. All in the family (sequence alignment) 4. The boulevard of broken genes (hidden Markov models) 5. Are Neanderthals among us? (variation within and between species) 6. Fighting HIV (natural selection at the molecular level) 7. SARS: a post-genomic epidemic (phylogenetic analysis) 8. Welcome to the hotel Chlamydia (whole genome comparisons) 9. The genomics of wine-making (analysis of gene expression) 10. A bed-time story (identification of regulatory sequences) Appendix.