Peptide therapy for Type I diabetes: the immunological homunculus and the rationale for vaccination
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[1] I. Cohen. Tending Adam's Garden: Evolving the Cognitive Immune Self , 2004 .
[2] I. Cohen,et al. The mycobacterial 65 kD heat-shock protein and autoimmune arthritis , 2004, Rheumatology International.
[3] H. Kolb,et al. The Receptor for Heat Shock Protein 60 on Macrophages Is Saturable, Specific, and Distinct from Receptors for Other Heat Shock Proteins1 , 2002, The Journal of Immunology.
[4] L. Steinman,et al. Multiple sclerosis: deeper understanding of its pathogenesis reveals new targets for therapy. , 2002, Annual review of neuroscience.
[5] I. Cohen,et al. β-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): a randomised, double-blind, phase II trial , 2001, The Lancet.
[6] H. Weiner,et al. Induction and mechanism of action of transforming growth factor‐β‐secreting Th3 regulatory cells , 2001, Immunological reviews.
[7] Sayuri Yamazaki,et al. Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance , 2001, Immunological reviews.
[8] Roland Martin,et al. Antigen-specific immunomodulation via altered peptide ligands , 2001, Journal of Molecular Medicine.
[9] H. Weiner,et al. Oral administration of insulin to neonates suppresses spontaneous and cyclophosphamide induced diabetes in the NOD mouse. , 2001, Journal of autoimmunity.
[10] I. Cohen,et al. Beta-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): a randomised, double-blind, phase II trial. , 2001, Lancet.
[11] A. Evans,et al. Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial , 2000, Nature Medicine.
[12] J. Frank,et al. Encephalitogenic potential of the myelin basic protein peptide (amino acids 83–99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand , 2000, Nature Medicine.
[13] C. Boitard,et al. Oral insulin administration and residual (β-cell function in recent-onset type 1 diabetes: a multicentre randomised controlled trial , 2000, The Lancet.
[14] I. Cohen,et al. Discrimination and dialogue in the immune system. , 2000, Seminars in immunology.
[15] H Atlan,et al. T cell proliferative responses of type 1 diabetes patients and healthy individuals to human hsp60 and its peptides. , 1999, Journal of autoimmunity.
[16] I. Cohen,et al. The pathogenicity of islet‐infiltrating lymphocytes in the non‐obese diabetic (NOD) mouse , 1999, Clinical and experimental immunology.
[17] M. Eisenstein,et al. The peptide-binding strategy of the MHC class II I-A molecules. , 1998, Immunology today.
[18] Irun R. Cohen,et al. Islet T Cells Secreting IFN-γ in NOD Mouse Diabetes: Arrest by p277 Peptide Treatment , 1998 .
[19] I. Cohen,et al. Islet T cells secreting IFN-gamma in NOD mouse diabetes: arrest by p277 peptide treatment. , 1998, Journal of autoimmunity.
[20] I. Cohen,et al. Biochemical characterization of the human diabetes‐associated HLA‐DQ8 allelic product: Similarity to the major histocompatibility complex class II I‐Ag7 protein of non‐obese diabetic mice , 1997, European journal of immunology.
[21] Irun R Cohen,et al. Hsp60 Peptide Therapy of NOD Mouse Diabetes Induces a Th2 Cytokine Burst and Downregulates Autoimmunity to Various β-Cell Antigens , 1997, Diabetes.
[22] M Eisenstein,et al. Molecular characterization of the diabetes-associated mouse MHC class II protein, I-Ag7. , 1997, International immunology.
[23] I. Cohen,et al. The hsp60 Peptide p277 Arrests the Autoimmune Diabetes Induced by the Toxin Streptozotocin , 1996, Diabetes.
[24] I. Cohen,et al. NOD mouse diabetes: the ubiquitous mouse hsp60 is a beta-cell target antigen of autoimmune T cells. , 1996, Journal of autoimmunity.
[25] I. Cohen,et al. A role of Hsp60 in autoimmune diabetes: analysis in a transgenic model. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[26] I. Cohen. Treatment of autoimmune disease: to activate or to deactivate? , 1995, Chemical immunology.
[27] I. Cohen,et al. Autoimmune Diabetes Induced by the β-cell Toxin STZ: Immunity to the 60-kDa Heat Shock Protein and to Insulin , 1994, Diabetes.
[28] I. Cohen,et al. Peptide therapy for diabetes in NOD mice , 1994, The Lancet.
[29] M. A. Bowman,et al. Prevention of diabetes in the NOD mouse: implications for therapeutic intervention in human disease. , 1994, Immunology today.
[30] I. Cohen. The cognitive paradigm and the immunological homunculus. , 1992, Immunology today.
[31] I. Cohen,et al. The cognitive principle challenges clonal selection. , 1992, Immunology today.
[32] I. Cohen,et al. Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[33] I. Cohen,et al. Autoimmunity, microbial immunity and the immunological homunculus. , 1991, Immunology today.
[34] I. Cohen,et al. Insulin-Mimicking Anti-Idiotypic Antibodies in Development of Spontaneous Autoimmune Diabetes in BB/E Rats , 1990, Diabetes.
[35] C. Boitard,et al. Limited Duration of Remission of Insulin Dependency in Children With Recent Overt Type I Diabetes Treated With Low-Dose Cyclosporin , 1990, Diabetes.
[36] S. Baekkeskov,et al. Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase , 1990, Nature.
[37] I. Cohen,et al. Induction and therapy of autoimmune diabetes in the non-obese diabetic (NOD/Lt) mouse by a 65-kDa heat shock protein. , 1990, Proceedings of the National Academy of Sciences of the United States of America.
[38] S. Baekkeskov,et al. Cellular and subcellular localization of an Mr 64,000 protein autoantigen in insulin-dependent diabetes. , 1990, The Journal of biological chemistry.
[39] S. Baekkeskov,et al. Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase , 1990, Nature.
[40] I. Cohen,et al. Control of experimental autoimmune encephalomyelitis by T cells responding to activated T cells. , 1989, Science.
[41] M. Mihatsch,et al. Factors associated with early remission of type I diabetes in children treated with cyclosporine. , 1988, The New England journal of medicine.
[42] I. Cohen,et al. Anti-idiotypic network induced by T cell vaccination against experimental autoimmune encephalomyelitis. , 1988, Science.
[43] I. Cohen,et al. Cloning of the mycobacterial epitope recognized by T lymphocytes in adjuvant arthritis , 1988, Nature.
[44] D. Monos,et al. Insulin dependent diabetes mellitus as an autoimmune disease. , 1988, In vivo.
[45] H. Kolb,et al. Mouse models of insulin dependent diabetes: low-dose streptozocin-induced diabetes and nonobese diabetic (NOD) mice. , 1987, Diabetes/metabolism reviews.
[46] I. Cohen,et al. Therapeutic vaccination against adjuvant arthritis using autoimmune T cells treated with hydrostatic pressure. , 1987, Proceedings of the National Academy of Sciences of the United States of America.
[47] I. Cohen,et al. Arthritis induced by a T-lymphocyte clone that responds to Mycobacterium tuberculosis and to cartilage proteoglycans. , 1985, Proceedings of the National Academy of Sciences of the United States of America.
[48] I. Cohen,et al. Mouse antibodies to the insulin receptor developing spontaneously as anti-idiotypes. I. Characterization of the antibodies. , 1984, The Journal of biological chemistry.
[49] I. Cohen,et al. Mouse antibodies to the insulin receptor developing spontaneously as anti-idiotypes. II. Effects on glucose homeostasis and the insulin receptor. , 1984, The Journal of biological chemistry.
[50] I. Cohen,et al. Arthritis induced in rats by cloned T lymphocytes responsive to mycobacteria but not to collagen type II. , 1984, The Journal of clinical investigation.
[51] B. M. Jongh,et al. Autoantibodies to the insulin receptor in juvenile onset insulin-dependent diabetes , 1983, Nature.
[52] I. Cohen,et al. Vaccination against autoimmune encephalomyelitis with T-lymphocite line cells reactive against myelin basic protein , 1981, Nature.
[53] I. Cohen,et al. The rapid isolation of clonable antigen‐specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis , 1981, European journal of immunology.
[54] V. Lev-Ram,et al. Immune response genes have a variable influence on the selection of antigenic foreign and self determinants of insulin. , 1979, Proceedings of the National Academy of Sciences of the United States of America.
[55] I. Cohen,et al. Non-Type Specific Resistance to Group A Streptococci in Germ Free and Conventional Mice.∗ , 1963, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.