Modified gellan gum hydrogels for tissue engineering applications

Gellan gum is an anionic linear polysaccharide well known for its use as a multi-functional gelling, stabilising and suspending agent in a variety of foods and personal care products. In this Highlight, we explore the recently established directions for gellan gum hydrogels as materials for applications in tissue engineering. We highlight that modified gellan gum will be well suited for this purpose, providing that a number of remaining challenges are addressed.

[1]  C. Lombry,et al.  Effect of the formulation on the in-vitro release of propranolol from gellan beads. , 1999, International journal of pharmaceutics.

[2]  Jian Ping Gong,et al.  Why are double network hydrogels so tough , 2010 .

[3]  Z. Suo,et al.  Highly stretchable and tough hydrogels , 2012, Nature.

[4]  Hugo Leite-Almeida,et al.  Development and characterization of a novel hybrid tissue engineering-based scaffold for spinal cord injury repair. , 2010, Tissue engineering. Part A.

[5]  G. Ciardelli,et al.  Transglutaminase Reactivity with Gelatine: Perspective Applications in Tissue Engineering , 2006, Biotechnology Letters.

[6]  G. Ciardelli,et al.  Bioartificial polymeric materials based on polysaccharides , 2001, Journal of biomaterials science. Polymer edition.

[7]  C. Satish,et al.  Formulation and Evaluation of Chitosan‐Gellan Based Methotrexate Implants , 2008 .

[8]  E. Ogawa.  Conformational Transition of Polysaccharide Sodium-Gellan Gum in Aqueous Solutions , 1996 .

[9]  B. Nikunj,et al.  Sustained ocular delivery of brimonidine tartrate using ion activated in situ gelling system. , 2012, Current Drug Delivery.

[10]  María Vallet-Regí,et al.  An alternative technique to shape scaffolds with hierarchical porosity at physiological temperature. , 2010, Acta biomaterialia.

[11]  Ali Khademhosseini,et al.  The mechanical properties and cytotoxicity of cell-laden double-network hydrogels based on photocrosslinkable gelatin and gellan gum biomacromolecules. , 2012, Biomaterials.

[12]  Gordon G Wallace,et al.  Bio-ink for on-demand printing of living cells. , 2013, Biomaterials science.

[13]  David J. Mooney,et al.  Growth Factors, Matrices, and Forces Combine and Control Stem Cells , 2009, Science.

[14]  Giovanni Vozzi,et al.  Blends of Poly-(ε-caprolactone) and Polysaccharides in Tissue Engineering Applications , 2005 .

[15]  K. Nishinari,et al.  Thermally induced coil‐to‐helix transition of sodium gellan gum with different molar masses in aqueous salt solutions , 2005, Biopolymers.

[16]  M. A. Tung,et al.  Compression strength and deformation of gellan gels formed with mono- and divalent cations , 1996 .

[17]  M. in het Panhuis,et al.  Gel-carbon nanotube materials: the relationship between nanotube network connectivity and conductivity. , 2010, Nanoscale.

[18]  M. Panhuis,et al.  The effect of preparation conditions and biopolymer dispersants on the properties of SWNT buckypapers , 2009 .

[19]  P. Dubruel,et al.  Enzymatic mineralization of gellan gum hydrogel for bone tissue‐engineering applications and its enhancement by polydopamine , 2014, Journal of tissue engineering and regenerative medicine.

[20]  Ali Khademhosseini,et al.  Modified Gellan Gum hydrogels with tunable physical and mechanical properties. , 2010, Biomaterials.

[21]  A. Nussinovitch,et al.  Hydrocolloid carriers with filler inclusion for diltiazem hydrochloride release. , 2007, Journal of pharmaceutical sciences.

[22]  Isabel Sá-Correia,et al.  Occurrence, production, and applications of gellan: current state and perspectives , 2008, Applied Microbiology and Biotechnology.

[23]  Thomas M. Higgins,et al.  Gellan gum doped polypyrrole neural prosthetic electrode coatings , 2011 .

[24]  T. Kurokawa,et al.  Double‐Network Hydrogels with Extremely High Mechanical Strength , 2003 .

[25]  Li Ren,et al.  In vitro engineered cartilage using synovium-derived mesenchymal stem cells with injectable gellan hydrogels. , 2010, Acta biomaterialia.

[26]  O. Smidsrod,et al.  Gelation of gellan gum , 1987 .

[27]  Ming-Wei Lee,et al.  Photocrosslinkable gellan gum film as an anti-adhesion barrier. , 2012, Carbohydrate polymers.

[28]  Dong-An Wang,et al.  An improved injectable polysaccharide hydrogel: modified gellan gum for long-term cartilage regeneration in vitro , 2009 .

[29]  Alan M. Smith,et al.  Degradation of polysaccharide hydrogels seeded with bone marrow stromal cells. , 2011, Journal of the mechanical behavior of biomedical materials.

[30]  E. Morris,et al.  Conformational and rheological transitions of welan, rhamsan and acylated gellan , 1996 .

[31]  A. Shiras,et al.  Gellan gum capped silver nanoparticle dispersions and hydrogels: cytotoxicity and in vitro diffusion studies. , 2012, Nanoscale.

[32]  M. Gomes,et al.  Injectable gellan gum hydrogels with autologous cells for the treatment of rabbit articular cartilage defects , 2010, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[33]  Rui L Reis,et al.  Development of gellan gum-based microparticles/hydrogel matrices for application in the intervertebral disc regeneration. , 2011, Tissue engineering. Part C, Methods.

[34]  K. Nishinari,et al.  Effects of molar mass on the coil to helix transition of sodium-type gellan gums in aqueous solutions , 2006 .

[35]  S. Maiti,et al.  Smart reticulated hydrogel of functionally decorated gellan copolymer for prolonged delivery of salbutamol sulphate to the gastro-luminal milieu , 2012, Journal of microencapsulation.

[36]  C. Cristallini,et al.  Hydroxyapatite/gelatin/gellan sponges as nanocomposite scaffolds for bone reconstruction , 2011, Journal of Materials Science: Materials in Medicine.

[37]  Yvonne Perrie,et al.  An Initial Evaluation of Gellan Gum as a Material for Tissue Engineering Applications , 2007, Journal of biomaterials applications.

[38]  P. Janmey,et al.  Tissue Cells Feel and Respond to the Stiffness of Their Substrate , 2005, Science.

[39]  Gen Kamita,et al.  Lamellar Bilayers as Reversible Sacrificial Bonds To Toughen Hydrogel: Hysteresis, Self-Recovery, Fatigue Resistance, and Crack Blunting , 2011 .

[40]  R. L. Reis,et al.  Gellan gum‐based hydrogels for intervertebral disc tissue‐engineering applications , 2011, Journal of tissue engineering and regenerative medicine.

[41]  Yuko Hori,et al.  Effect of pH on the conformation of gellan chains in aqueous systems. , 2004, Biophysical chemistry.

[42]  C. Green,et al.  Comparison of ion-activated in situ gelling systems for ocular drug delivery. Part 1: physicochemical characterisation and in vitro release. , 2011, International journal of pharmaceutics.

[43]  M. Dentini,et al.  The structure of gellan in dilute aqueous solution. , 2000, Biopolymers.

[44]  S. Arora,et al.  Ocular drug delivery system: a reference to natural polymers , 2012, Expert opinion on drug delivery.

[45]  Rui L Reis,et al.  Dynamic culturing of cartilage tissue: the significance of hydrostatic pressure. , 2012, Tissue engineering. Part A.

[46]  Peter Dubruel,et al.  A review of trends and limitations in hydrogel-rapid prototyping for tissue engineering. , 2012, Biomaterials.

[47]  J. S. Patil,et al.  Ionotropically Gelled Novel Hydrogel Beads: Preparation, Characterization and In vitro Evaluation , 2011, Indian journal of pharmaceutical sciences.

[48]  N. Ravi,et al.  Injectable in situ physically and chemically crosslinkable gellan hydrogel. , 2012, Macromolecular bioscience.

[49]  E. Morris,et al.  Gelation of gellan – A review , 2012 .

[50]  Y. Shindo,et al.  Gelation of gellan gum aqueous solutions studied by polarization modulation spectroscopy , 2004, Biopolymers.

[51]  Vesselin N Paunov,et al.  Inkjet printed water sensitive transparent films from natural gum-carbon nanotube composites. , 2007, Soft matter.

[52]  Aaas News,et al.  Book Reviews , 1893, Buffalo Medical and Surgical Journal.

[53]  A. Salgado,et al.  The effects of peptide modified gellan gum and olfactory ensheathing glia cells on neural stem/progenitor cell fate. , 2012, Biomaterials.

[54]  W. Marsden.  I and J , 2012 .

[55]  B. Jansson,et al.  The influence of gellan gum on the transfer of fluorescein dextran across rat nasal epithelium in vivo. , 2005, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[56]  S. Maeda,et al.  Effects of monovalent cation and anion species on the conformation of gellan chains in aqueous systems , 2005 .

[57]  M. in het Panhuis,et al.  Extrusion Printing of Flexible Electrically Conducting Carbon Nanotube Networks , 2012 .

[58]  P. Matricardi,et al.  Preparation and characterization of antimicrobial wound dressings based on silver, gellan, PVA and borax. , 2012, Carbohydrate polymers.

[59]  Marc in het Panhuis,et al.  Conducting bio-materials based on gellan gum hydrogels , 2009 .

[60]  G. G. Stokes.  "J." , 1890, The New Yale Book of Quotations.

[61]  M. Rinaudo,et al.  The gellan sol-gel transition , 1996 .

[62]  M. S. Kallos,et al.  Optimizing gelling parameters of gellan gum for fibrocartilage tissue engineering. , 2011, Journal of biomedical materials research. Part B, Applied biomaterials.

[63]  J. Vacanti,et al.  Tissue engineering : Frontiers in biotechnology , 1993 .

[64]  A. Fialho,et al.  Analysis of structure and function of gellans with different substitution patterns , 1998 .

[65]  A. L. Oliveira,et al.  Peripheral mineralization of a 3D biodegradable tubular construct as a way to enhance guidance stabilization in spinal cord injury regeneration , 2012, Journal of Materials Science: Materials in Medicine.

[66]  T. Kurokawa,et al.  Super tough double network hydrogels and their application as biomaterials , 2012 .

[67]  R. Chandrasekaran,et al.  Molecular architectures and functional properties of gellan gum and related polysaccharides , 1995 .

[68]  Kevin Barraclough,et al.  I and i , 2001, BMJ : British Medical Journal.

[69]  M. Panhuis,et al.  Polyelectrolyte complex materials from chitosan and gellan gum , 2011 .

[70]  Tejraj M Aminabhavi,et al.  Controlled release of cephalexin through gellan gum beads: effect of formulation parameters on entrapment efficiency, size, and drug release. , 2006, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[71]  M. Sefton,et al.  Tissue engineering. , 1998, Journal of cutaneous medicine and surgery.

[72]  Shannon E Bakarich,et al.  Recovery from applied strain in interpenetrating polymer network hydrogels with ionic and covalent cross-links , 2012 .

[73]  R L Reis,et al.  Gellan gum: a new biomaterial for cartilage tissue engineering applications. , 2009, Journal of biomedical materials research. Part A.

[74]  Yasmin Sultana,et al.  Ion-Activated, Gelrite®-Based in Situ Ophthalmic Gels of Pefloxacin Mesylate: Comparison with Conventional Eye Drops , 2006, Drug delivery.

[75]  M R Wisnom,et al.  The compressive strength of articular cartilage , 1998, Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine.

[76]  M. Rinaudo,et al.  On the physicochemical properties of gellan gum , 1990, Biopolymers.

[77]  Juming Tang,et al.  Texture properties of high and low acyl mixed gellan gels , 2000 .

[78]  A. P. Marques,et al.  Performance of new gellan gum hydrogels combined with human articular chondrocytes for cartilage regeneration when subcutaneously implanted in nude mice , 2009, Journal of tissue engineering and regenerative medicine.

[79]  Per-Erik Jansson,et al.  Structural studies of gellan gum, an extracellular polysaccharide elaborated by Pseudomonas elodea , 1983 .

[80]  M. Iwahashi,et al.  Conformational transition of gellan gum of sodium, lithium, and potassium types in aqueous solutions , 2002 .

[81]  Luhua Lu,et al.  Large-scale aligned carbon nanotubes from their purified, highly concentrated suspension. , 2010, ACS nano.

[82]  Daniela F. Coutinho,et al.  An automated two-phase system for hydrogel microbead production , 2012, Biofabrication.

[83]  Nuno M Neves,et al.  Gellan gum injectable hydrogels for cartilage tissue engineering applications: in vitro studies and preliminary in vivo evaluation. , 2010, Tissue engineering. Part A.

[84]  M. Dentini,et al.  Comparative analysis of the behavior of gellan gum (S-60) and welan gum (S-130) in dilute aqueous solution , 1986 .

[85]  M. Panhuis,et al.  Gel–carbon nanotube composites: the effect of carbon nanotubes on gelation and conductivity behaviour , 2009 .

[86]  T. J. Pollock.  Gellan-related polysaccharides and the genus Sphingomonas , 1993 .

[87]  Chunjie Wu,et al.  In Situ Gelling Gelrite/Alginate Formulations as Vehicles for Ophthalmic Drug Delivery , 2010, AAPS PharmSciTech.

[88]  E. Miyoshi.  Rheological and thermal studies of gel-sol transition in gellan gum aqueous solutions , 1996 .

[89]  K. Gilmore,et al.  Polyelectrolyte complex materials consisting of antibacterial and cell-supporting layers. , 2012, Macromolecular bioscience.

[90]  A. Salgado,et al.  Angiogenic potential of gellan-gum-based hydrogels for application in nucleus pulposus regeneration: in vivo study. , 2012, Tissue engineering. Part A.

[91]  Dong-An Wang,et al.  A novel gellan gel-based microcarrier for anchorage-dependent cell delivery. , 2008, Acta biomaterialia.

[92]  S. Suri,et al.  In vitro evaluation of in situ gels as short term vitreous substitutes. , 2006, Journal of biomedical materials research. Part A.