Alternative autophagy, brefeldin A and viral trafficking pathways

ABSTRACT Two topics that have attracted recent attention in the field of autophagy concern the source of the membrane that is used to form the autophagosome during macroautophagy and the role of noncanonical autophagic pathways. The 2 topics may converge when considering the intersection of autophagy with viral infection. We suggest that noncanonical autophagy, which is sensitive to treatment with brefeldin A, may converge with the infectious cycles of certain DNA and RNA viruses that utilize membrane from the ER and cis-Golgi.

[1]  W. Jackson.  Viruses and the autophagy pathway. , 2015, Virology.

[2]  Nektarios Tavernarakis,et al.  Unsaturated fatty acids induce non‐canonical autophagy , 2015, The EMBO journal.

[3]  J. Carpenter,et al.  The pros and cons of autophagic flux among herpesviruses , 2015, Autophagy.

[4]  R. Schekman,et al.  The ER–Golgi intermediate compartment is a key membrane source for the LC3 lipidation step of autophagosome biogenesis , 2013, eLife.

[5]  G. Neumann,et al.  Role of the GTPase Rab1b in Ebolavirus Particle Formation , 2010, Journal of Virology.

[6]  J. Lane,et al.  Alternative macroautophagy , 2010, Autophagy.

[7]  Zhijian Li,et al.  The conserved oligomeric Golgi complex is involved in double-membrane vesicle formation during autophagy , 2010, The Journal of cell biology.

[8]  K. Otsu,et al.  Discovery of Atg5/Atg7-independent alternative macroautophagy , 2009, Nature.

[9]  M. Havens,et al.  Human Papillomavirus Type 16 Infection of Human Keratinocytes Requires Clathrin and Caveolin-1 and Is Brefeldin A Sensitive , 2009, Journal of Virology.

[10]  M. Raaben,et al.  Mouse Hepatitis Coronavirus RNA Replication Depends on GBF1-Mediated ARF1 Activation , 2008, PLoS pathogens.

[11]  D. Stolz,et al.  Differential Effects of Endoplasmic Reticulum Stress-induced Autophagy on Cell Survival* , 2007, Journal of Biological Chemistry.

[12]  Simon C Watkins,et al.  Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium-induced cell death. , 2007, The American journal of pathology.

[13]  J. Cherfils,et al.  Arf, Sec7 and Brefeldin A: a model towards the therapeutic inhibition of guanine nucleotide-exchange factors. , 2005, Biochemical Society transactions.

[14]  J. Cherfils,et al.  Arf, Sec7 and Brefeldin A: a model towards the therapeutic inhibition of guanine nucleotide-exchange factors , 2005 .

[15]  H. Reunanen,et al.  Effects of brefeldin A on autophagy in cultured rat fibroblasts. , 1997, European journal of cell biology.

[16]  L. Enquist,et al.  Effect of brefeldin A on alphaherpesvirus membrane protein glycosylation and virus egress , 1991, Journal of virology.

[17]  K. Arima,et al.  Antiviral activity of brefeldin A and verrucarin A. , 1968, The Journal of antibiotics.