Direct regulation of Treslin by cyclin-dependent kinase is essential for the onset of DNA replication

Phosphorylation of human Treslin by Cdk is essential for its association with TopBP1 and for the initiation of DNA replication in S phase.

[1]  J. Diffley,et al.  Eukaryotic DNA replication control: lock and load, then fire. , 2009, Current opinion in cell biology.

[2]  Hiroyuki Araki,et al.  CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast , 2007, Nature.

[3]  David O. Morgan,et al.  Cyclin specificity in the phosphorylation of cyclin-dependent kinase substrates , 2005, Nature.

[4]  Bruce Stillman,et al.  Perpetuating the double helix: molecular machines at eukaryotic DNA replication origins. , 2003, BioEssays : news and reviews in molecular, cellular and developmental biology.

[5]  M. Botchan.  Cell biology: A switch for S phase , 2007, Nature.

[6]  A. Shevchenko,et al.  Treslin Collaborates with TopBP1 in Triggering the Initiation of DNA Replication , 2010, Cell.

[7]  W. Dunphy,et al.  Cell cycle control by Xenopus p28Kix1, a developmentally regulated inhibitor of cyclin-dependent kinases. , 1996, Molecular biology of the cell.

[8]  H. Araki,et al.  Regulation of the initiation step of DNA replication by cyclin-dependent kinases , 2010, Chromosoma.

[9]  A. Shevchenko,et al.  Roles of replication fork-interacting and Chk1-activating domains from Claspin in a DNA replication checkpoint response. , 2005, Molecular biology of the cell.

[10]  M. Kumano,et al.  The N-Terminal Noncatalytic Region of Xenopus RecQ4 Is Required for Chromatin Binding of DNA Polymerase α in the Initiation of DNA Replication , 2006, Molecular and Cellular Biology.

[11]  J. Walter,et al.  DNA Replication: Metazoan Sld3 Steps Forward , 2010, Current Biology.

[12]  C. Sansam,et al.  A vertebrate gene, ticrr, is an essential checkpoint and replication regulator. , 2010, Genes & development.

[13]  M. Botchan,et al.  Activation of the MCM2-7 helicase by association with Cdc45 and GINS proteins. , 2010, Molecular cell.

[14]  J. Diffley,et al.  Regulation of Early Events in Chromosome Replication , 2004, Current Biology.

[15]  H. Araki,et al.  The role of CDK in the initiation step of DNA replication in eukaryotes , 2007, Cell Division.

[16]  A. Venkitaraman,et al.  Initiation of DNA Replication Requires the RECQL4 Protein Mutated in Rothmund-Thomson Syndrome , 2005, Cell.

[17]  M. Mann,et al.  In-gel digestion for mass spectrometric characterization of proteins and proteomes , 2006, Nature Protocols.

[18]  A. Carr,et al.  Identification and functional analysis of TopBP1 and its homologs. , 2005, DNA repair.

[19]  D O Morgan,et al.  Cyclin-dependent kinases: engines, clocks, and microprocessors. , 1997, Annual review of cell and developmental biology.

[20]  B. Schulman,et al.  Substrate recruitment to cyclin-dependent kinase 2 by a multipurpose docking site on cyclin A. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[21]  V. Costanzo,et al.  GEMC1 is a TopBP1 interacting protein required for chromosomal DNA replication , 2010, Nature Cell Biology.

[22]  K. Labib.  How do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells? , 2010, Genes & development.

[23]  Hiroyuki Araki,et al.  Cyclin-dependent kinase-dependent initiation of chromosomal DNA replication. , 2010, Current opinion in cell biology.

[24]  H. Araki,et al.  Sld3, which interacts with Cdc45 (Sld4), functions for chromosomal DNA replication in Saccharomyces cerevisiae , 2001, The EMBO journal.

[25]  A. Shevchenko,et al.  Separating the wheat from the chaff: unbiased filtering of background tandem mass spectra improves protein identification. , 2008, Journal of proteome research.

[26]  J. Walter,et al.  The Xenopus Xmus101 protein is required for the recruitment of Cdc45 to origins of DNA replication , 2002, The Journal of cell biology.

[27]  X. Chen,et al.  The DNA Unwinding Element Binding Protein DUE-B Interacts with Cdc45 in Preinitiation Complex Formation , 2010, Molecular and Cellular Biology.

[28]  J. Diffley,et al.  Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast , 2007, Nature.

[29]  H. Takisawa,et al.  Xenopus Cut5 is essential for a CDK‐dependent process in the initiation of DNA replication , 2003, The EMBO journal.

[30]  M. Pacek,et al.  Localization of MCM2-7, Cdc45, and GINS to the site of DNA unwinding during eukaryotic DNA replication. , 2006, Molecular cell.

[31]  R. Sclafani,et al.  Cell cycle regulation of DNA replication. , 2007, Annual review of genetics.

[32]  C. Ponting,et al.  Homology explains the functional similarities of Treslin/Ticrr and Sld3 , 2010, Current Biology.

[33]  Jimmy K. Eng,et al.  Quantitative Phosphoproteomic Analysis of T Cell Receptor Signaling Reveals System-Wide Modulation of Protein-Protein Interactions , 2009, Science Signaling.

[34]  T. Nakagawa,et al.  Ordered assembly of Sld3, GINS and Cdc45 is distinctly regulated by DDK and CDK for activation of replication origins , 2006, The EMBO journal.