High failure rate of transungal drug delivery: need for new strategies.

Nails are the toughest part of the human body. However, due to unabated exposure to environment stress and day-to-day chores, they are highly prone to infections. Onychomycosis is the fungal infection of the nail that can involve one or more of the nail unit components. Infection generally initiates from the distal portion of the toe or finger nail and later spreads to the proximal portion of the nail matrix. The whole width of the nail may be affected. Subsequently, it spreads proximally toward the posterior nail fold and medially to encompass the whole nail bed. In this process, nail can become grossly thickened, and may get completely destroyed [1].