Otitis media across nine countries: disease burden and management.

OBJECTIVE To assess the perceived disease burden and management of otitis media (OM) among an international cohort of experienced physicians. METHODS A cross-sectional survey conducted in France, Germany, Spain, Poland, Argentina, Mexico, South Korea, Thailand and Saudi Arabia. Face-to-face interviews conducted with 1800 physicians (95% paediatricians, 5% family practitioners).Main outcome measures were the perceived burden on clinical practice (number of cases, complications and referrals) and first- and second-line management strategies for OM. Results are expressed as mean and range across the nine countries over three continents. RESULTS Respondents estimated an average annual caseload of 375 (range 128-1003) children under 5 years of age with OM; 54% (range 44-71%) with an initial episode and 38% (range 27-54%) with recurrent OM (ROM). OM with complications was estimated to be approximately 20 (range 7-49) cases per year and an estimated 15% (8-41%) of children with OM was recalled as needing specialist referral. There was high awareness of Streptococcus pneumoniae and Haemophilus influenzae as causative bacterial pathogens: 77% (range 65-91%) and 74% (range 68-83%), respectively, but less recognition of non-typeable H. influenzae (NTHi); 59% (range 45-67%). Although concern over antimicrobial resistance was widespread, empirical treatment with antibiotics was the most common first-line treatment (mean 81%, range 40-96%). The burden of disease is substantial enough that many physicians would consider vaccination to prevent OM (mean score 5.1, range 4.3-6.2 on 1-7 scale). CONCLUSIONS This large, multinational survey shows that OM remains a significant burden for clinical practice. Despite awareness of shortcomings, antimicrobial therapy remains the most frequent treatment for OM.

[1]  R. Dolor,et al.  Quality of Life of Patients With Otitis Media and Caregivers: A Multicenter Study , 2006, The Laryngoscope.

[2]  R. Dagan,et al.  Seasonal Distribution of Otitis Media Pathogens Among Costa Rican Children , 2008, The Pediatric infectious disease journal.

[3]  John W. Wilson,et al.  Respiratory Tract Infections , 2011 .

[4]  D. L. Klein,et al.  Vaccines for otitis media: proposals for overcoming obstacles to progress. , 2005, Vaccine.

[5]  L Culpepper,et al.  Diagnosis and antibiotic treatment of acute otitis media: report from International Primary Care Network. , 1990, BMJ.

[6]  P. Berche,et al.  Microbiology of otitis media in the Paris, France, area from 1987 to 1997. , 2001, The Pediatric infectious disease journal.

[7]  O. Cars,et al.  Variation in antibiotic use in the European Union , 2001, The Lancet.

[8]  H.-M. Mühlenfeld,et al.  Die neue DEGAM-Leitlinie Nr. 7 „Ohrenschmerzen” , 2005 .

[9]  Donald H. Arnold,et al.  Wait-and-see prescription for the treatment of acute otitis media: a randomized controlled trial. , 2006, JAMA.

[10]  A. Shefer,et al.  Trends in Acute Otitis Media-Related Health Care Utilization by Privately Insured Young Children in the United States, 1997–2004 , 2008, Pediatrics.

[11]  T. Pokka,et al.  Costs arising from otitis media , 1999, Acta paediatrica.

[12]  D. Mccormick,et al.  Nonsevere Acute Otitis Media: A Clinical Trial Comparing Outcomes of Watchful Waiting Versus Immediate Antibiotic Treatment , 2005, Pediatrics.

[13]  R. Rosenfeld,et al.  Evidence-Based Otitis Media , 2003 .

[14]  A. Radzikowski,et al.  Zakażenia dróg oddechowych. Antybiotykoterapia – tak czy nie? Długo czy krótko? , 2007 .

[15]  A. Cripps,et al.  Bacterial otitis media: a vaccine preventable disease? , 2005, Vaccine.

[16]  A. Mitchell,et al.  Management of Acute Otitis Media by Primary Care Physicians: Trends Since the Release of the 2004 American Academy of Pediatrics/American Academy of Family Physicians Clinical Practice Guideline , 2007, Pediatrics.

[17]  D. Greenberg,et al.  The burden of acute otitis media on the patient and the family , 2003, European Journal of Pediatrics.

[18]  C. Whitney,et al.  Vaccines as tools against resistance: the example of pneumococcal conjugate vaccine. , 2004, Seminars in pediatric infectious diseases.

[19]  E. Sanders,et al.  Otitis media and its consequences: beyond the earache. , 2010, The Lancet. Infectious diseases.

[20]  T. Lieu,et al.  COSTS OF OTITIS MEDIA IN A MANAGED CARE POPULATION , 2000, The Pediatric infectious disease journal.

[21]  R. Dagan,et al.  Haemophilus influenzae: A Significant Pathogen in Acute Otitis Media , 2004, The Pediatric infectious disease journal.

[22]  J. Klein,et al.  The burden of otitis media. , 2000, Vaccine.

[23]  Agence Française de Sécurité,et al.  Systemic antibiotic treatment in upper and lower respiratory tract infections: official French guidelines. , 2003, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

[24]  M. Pichichero Evolving shifts in otitis media pathogens: relevance to a managed care organization. , 2005, The American journal of managed care.

[25]  Donald H. Arnold,et al.  The concept and practice of a wait-and-see approach to acute otitis media , 2008, Current opinion in pediatrics.

[26]  D. Malone,et al.  Excessive antibiotic use for acute respiratory infections in the United States. , 2001, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[27]  R. Rooks,et al.  Ambulatory health care visits by children: principal diagnosis and place of visit. , 1998, Vital and health statistics. Series 13, Data from the National Health Survey.

[28]  K. Poehling,et al.  National Impact of Universal Childhood Immunization With Pneumococcal Conjugate Vaccine on Outpatient Medical Care Visits in the United States , 2006, Pediatrics.

[29]  G. Gates,et al.  Measuring the indirect and direct costs of acute otitis media. , 1999, Archives of otolaryngology--head & neck surgery.

[30]  R. Rosenfeld,et al.  Otitis media , 1994, The Lancet.

[31]  M. López,et al.  Epidemiología e impacto de la otitis media aguda en la Comunidad Valenciana , 2004 .

[32]  H. Goossens,et al.  Outpatient antibiotic use in Europe and association with resistance: a cross-national database study , 2005, The Lancet.

[33]  C. Brouwer,et al.  The impact of recurrent acute otitis media on the quality of life of children and their caregivers , 2005, Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery.

[34]  E. Cantekin,et al.  Antibiotics Are Not Effective for Otitis media with Effusion: Reanalysis of Meta-Analyses , 1999, Oto-Rhino-Laryngologia Nova.