Invited review The cytology of malignant mesothelioma

Over the last 30 years there has been a world wide increase in the incidence of malignant mesothelioma, mainly associated with prior exposure to asbestos dust. Mesotheliomas often present with recurrent serous effusions that are usually sent for cytological examination. This review documents the introduction, development and state of the art of cytopathology in the diagnosis of malignant mesothelioma.

[1]  A. Hjerpe,et al.  Reactivity of six antibodies in effusions of mesothelioma, adenocarcinoma and mesotheliosis: stepwise logistic regression analysis , 2000, Cytopathology : official journal of the British Society for Clinical Cytology.

[2]  M. Akin,et al.  Cytopathology of malignant mesothelioma of the pleura in fine‐needle aspiration biopsy , 1999, Diagnostic cytopathology.

[3]  M. Sack,et al.  Occurrence of intercellular spaces (windows) in metastatic adenocarcinoma in serous fluids: A cytomorphologic, histochemical, and ultrastructural study , 1999, Diagnostic cytopathology.

[4]  H. Cramer,et al.  Cytologic diagnosis of malignant mesothelioma, with particular emphasis on the epithelial noncohesive cell type , 1999, Diagnostic cytopathology.

[5]  P. Tabaczka,et al.  Value of Ki67 immunostain in identification of malignancy in serous effusions , 1999, Diagnostic cytopathology.

[6]  P. Tabaczka,et al.  Improved Detection of Adenocarcinoma of Serous Fluids with p53 Immunocytochemistry , 1998, Acta Cytologica.

[7]  N. Ordóñez Value of calretinin immunostaining in differentiating epithelial mesothelioma from lung adenocarcinoma. , 1998, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.

[8]  N. Ordóñez,et al.  Value of cytokeratin 5/6 immunostaining in distinguishing epithelial mesothelioma of the pleura from lung adenocarcinoma. , 1998, The American journal of surgical pathology.

[9]  J. King,et al.  Evaluation of membranous staining of mesothelioma. , 1998, Cell vision : the journal of analytical morphology.

[10]  F. Nardi,et al.  Utility of HBME‐1 immunostaining in serous effusions , 1997, Cytopathology : official journal of the British Society for Clinical Cytology.

[11]  C. Michael,et al.  Confocal laser scanning microscopy and three‐dimensional reconstruction of cell clusters in serous fluids , 1997, Diagnostic cytopathology.

[12]  H. Vainio,et al.  Trends in mesothelioma incidence and occupational mesotheliomas in Finland in 1960-1995. , 1997, Scandinavian journal of work, environment & health.

[13]  T. H. van der Kwast,et al.  Complementary value of five carcinoma markers for the diagnosis of malignant mesothelioma, adenocarcinoma metastasis, and reactive mesothelium in serous effusions , 1997, Diagnostic cytopathology.

[14]  J. Oates,et al.  Anti‐cytokeratin 5/6: a positive marker for epithelioid mesothelioma , 1997, Histopathology.

[15]  B. Price Analysis of current trends in United States mesothelioma incidence. , 1997, American journal of epidemiology.

[16]  A. Renshaw,et al.  The role of cytologic evaluation of pleural fluid in the diagnosis of malignant mesothelioma. , 1997, Chest.

[17]  G. Viale,et al.  Calretinin: a novel immunocytochemical marker for mesothelioma. , 1996, The American journal of surgical pathology.

[18]  M. C. Lee,et al.  Immunohistochemical panel for distinguishing between carcinoma and reactive mesothelial cells in serious effusions. , 1996, Acta cytologica.

[19]  P. Johansen,et al.  Immunocytochemical staining of smears and corresponding cell blocks from serous effusions: A follow‐up and comparative investigation , 1996, Diagnostic cytopathology.

[20]  P. Vogt,et al.  The calcium binding protein calretinin is a selective marker for malignant pleural mesotheliomas of the epithelial type. , 1996, Pathology, research and practice.

[21]  I. Ramzy,et al.  p53 gene product in pleural effusions. Practical use in distinguishing benign from malignant cells. , 1996, Acta cytologica.

[22]  J. Silverman,et al.  Significance of epithelial membrane antigen in the work‐up of problematic serous effusions , 1995, Diagnostic cytopathology.

[23]  J. Peto,et al.  Continuing increase in mesothelioma mortality in Britain , 1995, The Lancet.

[24]  P. Fetsch,et al.  Ov632 as a possible marker for malignant mesothelioma: High expectations; Low specificity , 1995, Diagnostic cytopathology.

[25]  J. Young,et al.  Immunofluorescent staining of metastatic carcinoma cells in serous fluid with carcinoembryonic antibody, epithelial membrane antibody, AUA‐1 and BER‐EP4 , 1994, Cytopathology : official journal of the British Society for Clinical Cytology.

[26]  P. Devine,et al.  Markers for metastatic adenocarcinoma in serous effusion specimens , 1994, Diagnostic cytopathology.

[27]  D. Whitaker,et al.  Monoclonal antibody Ber‐EP4: Its use in the differential diagnosis of malignant mesothelioma and carcinoma in cell blocks of malignant effusions and FNA specimens , 1994, Diagnostic cytopathology.

[28]  A. Hjerpe,et al.  Immunohistochemical reactivity in mesothelioma and adenocarcinoma: A stepwise logistic regression analysis , 1994, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

[29]  J Espinosa Arranz,et al.  [Malignant mesothelioma]. , 1994, Medicina clinica.

[30]  D. Allred,et al.  Multiple-marker immunohistochemical phenotypes distinguishing malignant pleural mesothelioma from pulmonary adenocarcinoma. , 1993, Human pathology.

[31]  W. Mccarthy,et al.  Immunocytochemistry in the differential diagnosis of effusions: use of logistic regression to select a panel of antibodies to distinguish adenocarcinomas from mesothelial proliferations. , 1993, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.

[32]  G. Falconieri,et al.  Cytopathology of malignant mesothelioma: A study of its patterns and histological bases , 1993, Diagnostic cytopathology.

[33]  B. Naylor,et al.  "Collagen balls" in peritoneal washings. Prevalence, morphology, origin and significance. , 1992, Acta cytologica.

[34]  A. Leong,et al.  Cytopathology of malignant mesothelioma: A stepwise logistic regression analysis , 1992, Diagnostic cytopathology.

[35]  A. Leong,et al.  Malignant mesothelioma: cytologic diagnosis with histologic, immunohistochemical, and ultrastructural correlation. , 1992, Seminars in diagnostic pathology.

[36]  A. Heryet,et al.  Immunocytochemical Staining of Serous Effusions With the Monoclonal Antibody Ber‐Ep4 , 1992, Cytopathology : official journal of the British Society for Clinical Cytology.

[37]  J. Silverman,et al.  Immunocytochemical panel for the identification of malignant cells in serous effusions. , 1991, American journal of clinical pathology.

[38]  G. Mårtensson Diagnosing malignant pleural mesothelioma. , 1990, The European respiratory journal.

[39]  M. Sherman,et al.  Effusion cytology in the diagnosis of malignant epithelioid and biphasic pleural mesothelioma. , 1990, Archives of pathology & laboratory medicine.

[40]  C. Cohen,et al.  Distinction between carcinoma cells and mesothelial cells in serous effusions. Usefulness of immunohistochemistry. , 1990, Acta cytologica.

[41]  H. Hoogsteden,et al.  Cytopathology of malignant mesothelioma. Reappraisal of the diagnostic value of collagen cores , 1990, Cytopathology : official journal of the British Society for Clinical Cytology.

[42]  G. Pinkus,et al.  ME1. A monoclonal antibody that distinguishes epithelial-type malignant mesothelioma from pulmonary adenocarcinoma and extrapulmonary malignancies. , 1990, The American journal of pathology.

[43]  A. Leong,et al.  “Thick” cell membranes revealed by immunocytochemical staining: A clue to the diagnosis of mesothelioma , 1990, Diagnostic cytopathology.

[44]  L. Tao Aspiration biopsy cytology of mesothelioma , 1989, Diagnostic cytopathology.

[45]  T. H. van der Kwast,et al.  Expression of epithelial membrane antigen on malignant mesothelioma cells. An immunocytochemical and immunoelectron microscopic study. , 1988, Acta cytologica.

[46]  R. Lilis,et al.  Malignant mesothelioma in a cohort of asbestos insulation workers: clinical presentation, diagnosis, and causes of death. , 1988, British journal of industrial medicine.

[47]  J. Triol,et al.  Distinguishing adenocarcinoma from mesothelioma in effusions. , 1987, Human Pathology.

[48]  G. Sterrett,et al.  Fine needle aspiration cytology of malignant mesothelioma. , 1987, Acta cytologica.

[49]  J. Said,et al.  Epithelial membrane antigen in the cytodiagnosis of effusions and aspirates: Immunocytochemical and ultrastructural localization in benign and malignant cells , 1987, Diagnostic cytopathology.

[50]  P. Betta,et al.  New marker for mesothelioma: an immunoperoxidase study. , 1986, Journal of clinical pathology.

[51]  H. Ehya The cytologic diagnosis of mesothelioma. , 1986, Seminars in diagnostic pathology.

[52]  D. Whitaker,et al.  Diagnosis of pleural malignant mesothelioma in life—a practical approach , 1984, The Journal of pathology.

[53]  J. Triol,et al.  Malignant mesothelioma. Cytopathology of 75 cases seen in a New Jersey community hospital. , 1984, Acta cytologica.

[54]  W. Kwee,et al.  Quantitative and qualitative differences between benign and malignant mesothelial cells in pleural fluid. , 1982, Acta cytologica.

[55]  K. Antman Current concepts: malignant mesothelioma. , 1980, The New England journal of medicine.

[56]  Spriggs Ai,et al.  Benign mesothelial proliferation with collagen formation in pericardial fluid. , 1979 .

[57]  T. Whiteside,et al.  Immunodiagnosis of mesothelioma. Use of antimesothelial cell serum in an indirect immunofluorescence assay , 1979, Cancer.

[58]  Tao Lc The cytopathology of mesothelioma. , 1979 .

[59]  L. Tao The cytopathology of mesothelioma. , 1979, Acta cytologica.

[60]  A. I. Spriggs,et al.  Benign mesothelial proliferation with collagen formation in pericardial fluid. , 1979, Acta cytologica.

[61]  D. Whitaker,et al.  The cytology of malignant mesothelioma in Western Australia. , 1978, Acta cytologica.

[62]  J R Edge,et al.  Malignant mesothelioma of the pleura in Barrow-in-Furness. , 1978, Thorax.

[63]  D. Whitaker Cell aggregates in malignant mesothelioma. , 1977, Acta cytologica.

[64]  P. Elmes,et al.  The clinical aspects of mesothelioma. , 1976, The Quarterly journal of medicine.

[65]  D. Rosenthal,et al.  Mesothelial papilloma: a case of mistaken identity in a pericardial effusion. , 1976, Acta cytologica.

[66]  G. H. Roberts,et al.  Exfoliative cytology of diffuse mesothelioma , 1972, Journal of clinical pathology.

[67]  B. Naylor,et al.  THE EXFOLIATIVE CYTOLOGY OF DIFFUSE MALIGNANT MESOTHELIOMA. , 1963, The Journal of pathology and bacteriology.

[68]  S. Klempman The exfoliative cytology of diffuse pleural mesothelioma , 1962, Cancer.

[69]  F. Takagi Studies on tumor cells in serous effusion. , 1954, American journal of clinical pathology.