Recent Developments of PFAS-Detecting Sensors and Future Direction: A Review

Per- and poly-fluoroalkyl substances (PFASs) have recently been labeled as toxic constituents that exist in many aqueous environments. However, traditional methods used to determine the level of PFASs are often not appropriate for continuous environmental monitoring and management. Based on the current state of research, PFAS-detecting sensors have surfaced as a promising method of determination. These sensors are an innovative solution with characteristics that allow for in situ, low-cost, and easy-to-use capabilities. This paper presents a comprehensive review of the recent developments in PFAS-detecting sensors, and why the literature on determination methods has shifted in this direction compared to the traditional methods used. PFAS-detecting sensors discussed herein are primarily categorized in terms of the detection mechanism used. The topics covered also include the current limitations, as well as insight on the future direction of PFAS analyses. This paper is expected to be useful for the smart sensing technology development of PFAS detection methods and the associated environmental management best practices in smart cities of the future.

[1]  Xiaomeng Wang,et al.  Occurrence and inputs of perfluoroalkyl substances (PFASs) from rivers and drain outlets to the Bohai Sea, China. , 2017, Environmental pollution.

[2]  B. Peter McGrail,et al.  Metal-Organic Framework Based Microfluidic Impedance Sensor Platform for Ultrasensitive Detection of Perfluorooctanesulfonate. , 2020, ACS applied materials & interfaces.

[3]  H. Cho,et al.  A novel Fe-Chitosan-coated carbon electrode sensor for in situ As(III) detection in mining wastewater and soil leachate , 2019, Sensors and Actuators B: Chemical.

[4]  Q. Cai,et al.  Surface molecular imprinting on dye–(NH2)–SiO2 NPs for specific recognition and direct fluorescent quantification of perfluorooctane sulfonate , 2014 .

[5]  Jerald L Schnoor,et al.  Detection of perfluorooctane surfactants in Great Lakes water. , 2004, Environmental science & technology.

[6]  L. Tetard,et al.  In Situ Monitoring of Pb2+ Leaching from the Galvanic Joint Surface in a Prepared Chlorinated Drinking Water. , 2018, Environmental science & technology.

[7]  Bogdan Szostek,et al.  Quantitative determination of perfluorooctanoic acid in serum and plasma by liquid chromatography tandem mass spectrometry. , 2005, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[8]  Long Luo,et al.  Bubble-Nucleation-Based Method for the Selective and Sensitive Electrochemical Detection of Surfactants. , 2019, Analytical chemistry.

[9]  W. Lee,et al.  Microelectrode investigation on the corrosion initiation at lead-brass galvanic interfaces in chlorinated drinking water. , 2019, Langmuir : the ACS journal of surfaces and colloids.

[10]  J. Matsui,et al.  Colorimetric Detection of Perfluorooctanoic Acid (PFOA) Utilizing Polystyrene-Modified Gold Nanoparticles , 2012 .

[11]  Liang Wang,et al.  Smartphone app-based/portable sensor for the detection of fluoro-surfactant PFOA. , 2018, Chemosphere.

[12]  R. Halden,et al.  National inventory of perfluoroalkyl substances in archived U.S. biosolids from the 2001 EPA National Sewage Sludge Survey. , 2013, Journal of hazardous materials.

[13]  R. Naidu,et al.  Potentiometric detection of AFFFs based on MIP , 2016 .

[14]  H. Zieliński,et al.  Method development for the determination of PFOA and PFOS in honey based on the dispersive Solid Phase Extraction (d-SPE) with micro-UHPLC–MS/MS system , 2015 .

[15]  Lan Liu An UHPLC-MS/MS Quantitative Method for Trace Analysis of Per- and Polyfluoroalkyl Substances (PFASs) in Environmental Media from Alabama Estuaries , 2018 .

[16]  Antonio Varriale,et al.  A High Sensitivity Biosensor to detect the presence of perfluorinated compounds in environment. , 2018, Talanta.

[17]  J. Bayona,et al.  Determination of perfluorocarboxylic acids in aqueous matrices by ion-pair solid-phase microextraction-in-port derivatization-gas chromatography-negative ion chemical ionization mass spectrometry. , 2004, Journal of chromatography. A.

[18]  T. Greibrokk,et al.  On-line SPE-Nano-LC-Nanospray-MS for rapid and sensitive determination of perfluorooctanoic acid and perfluorooctane sulfonate in river water. , 2007, Journal of chromatographic science.

[19]  M. Dziedzic,et al.  Comparing methods to improve reliable sensor deployment time in continuous water quality monitoring , 2020, Water Supply.

[20]  Zongsu Wei,et al.  Treatment of per- and polyfluoroalkyl substances in landfill leachate: status, chemistry and prospects , 2019, Environmental Science: Water Research & Technology.

[21]  S. Lo,et al.  Effects of titanate nanotubes synthesized by a microwave hydrothermal method on photocatalytic decomposition of perfluorooctanoic acid. , 2011, Water research.

[22]  Anna Palm Cousins,et al.  Stockholm Arlanda Airport as a source of per- and polyfluoroalkyl substances to water, sediment and fish. , 2015, Chemosphere.

[23]  Ming-lin Wang,et al.  Preconcentration and Determination of Perfluoroalkyl Substances (PFASs) in Water Samples by Bamboo Charcoal-Based Solid-Phase Extraction Prior to Liquid Chromatography–Tandem Mass Spectrometry , 2018, Molecules.

[24]  S. Nakayama,et al.  Worldwide trends in tracing poly- and perfluoroalkyl substances (PFAS) in the environment , 2019 .

[25]  Yaqi Cai,et al.  Sensitive colorimetric visualization of perfluorinated compounds using poly(ethylene glycol) and perfluorinated thiols modified gold nanoparticles. , 2014, Analytical chemistry.

[26]  Woo Hyoung Lee,et al.  Amperometric carbon fiber nitrite microsensor for in situ biofilm monitoring , 2013 .

[27]  W. Lee,et al.  A novel approach for in situ monitoring of Zn in citrus plants using two-step square-wave anodic stripping voltammetry , 2018 .

[28]  R. Buck,et al.  Determination of fluorotelomer alcohols by liquid chromatography/tandem mass spectrometry in water. , 2006, Rapid communications in mass spectrometry : RCM.

[29]  Jack Thompson,et al.  Removal of PFOS, PFOA and other perfluoroalkyl acids at water reclamation plants in South East Queensland Australia. , 2011, Chemosphere.

[30]  J. Pawliszyn,et al.  Applications of solid-phase microextraction in food analysis. , 2000, Journal of chromatography. A.

[31]  Rajendra Kumar Dwivedi,et al.  Integration of Wireless Sensor Networks with Cloud: A Review , 2019, 2019 9th International Conference on Cloud Computing, Data Science & Engineering (Confluence).

[32]  Woo Hyoung Lee,et al.  Needle-type environmental microsensors: design, construction and uses of microelectrodes and multi-analyte MEMS sensor arrays , 2011 .

[33]  J. Allen,et al.  A Review of the Pathways of Human Exposure to Poly- and Perfluoroalkyl Substances (PFASs) and Present Understanding of Health Effects , 2018, Journal of Exposure Science & Environmental Epidemiology.

[34]  Xiaojia Huang,et al.  Efficient extraction of perfluorocarboxylic acids in complex samples with a monolithic adsorbent combining fluorophilic and anion-exchange interactions. , 2018, Analytica chimica acta.

[35]  Francesco Mattiello,et al.  A Simple and Low-Cost Optical Fiber Intensity-Based Configuration for Perfluorinated Compounds in Water Solution , 2018, Sensors.

[36]  P. Bishop,et al.  Free chlorine and monochloramine application to nitrifying biofilm: comparison of biofilm penetration, activity, and viability. , 2011, Environmental science & technology.

[37]  X. Xia,et al.  A comparative study on sorption of perfluorooctane sulfonate (PFOS) by chars, ash and carbon nanotubes. , 2011, Chemosphere.

[38]  H. Laudon,et al.  Mass Balance of Perfluorinated Alkyl Acids in a Pristine Boreal Catchment. , 2015, Environmental science & technology.

[39]  Andreas Stein,et al.  Fluorous membrane ion-selective electrodes for perfluorinated surfactants: trace-level detection and in situ monitoring of adsorption. , 2013, Analytical chemistry.

[40]  Mohammad Sohel Rahman,et al.  Behaviour and fate of perfluoroalkyl and polyfluoroalkyl substances (PFASs) in drinking water treatment: a review. , 2014, Water research.

[41]  R. Cela,et al.  Ion-pair sorptive extraction of perfluorinated compounds from water with low-cost polymeric materials: polyethersulfone vs polydimethylsiloxane. , 2012, Analytica chimica acta.

[42]  Oliver A.H. Jones,et al.  Micro versus macro solid phase extraction for monitoring water contaminants: a preliminary study using trihalomethanes. , 2015, The Science of the total environment.

[43]  P. Bishop,et al.  Characteristics of a cobalt-based phosphate microelectrode for in situ monitoring of phosphate and its biological application. , 2009, Sensors and actuators. B, Chemical.

[44]  J. Niu,et al.  Electrochemical degradation of perfluorooctanoic acid (PFOA) by Ti/SnO2-Sb, Ti/SnO2-Sb/PbO2 and Ti/SnO2-Sb/MnO2 anodes. , 2012, Water research.

[45]  Gerardo Toro-Farmer,et al.  Satellite Remote Sensing for Coastal Management: A Review of Successful Applications , 2017, Environmental Management.

[46]  Jae-Hoon Hwang,et al.  A novel nanoporous bismuth electrode sensor for in situ heavy metal detection , 2019, Electrochimica Acta.

[47]  E. Psillakis,et al.  Fast screening of perfluorooctane sulfonate in water using vortex-assisted liquid-liquid microextraction coupled to liquid chromatography-mass spectrometry. , 2011, Analytica chimica acta.

[48]  Lifeng Zhang,et al.  Study on the matrix effect in the determination of selected pharmaceutical residues in seawater by solid-phase extraction and ultra-high-performance liquid chromatography-electrospray ionization low-energy collision-induced dissociation tandem mass spectrometry. , 2010, Journal of chromatography. A.

[49]  Luigi Zeni,et al.  Water monitoring in smart cities exploiting plastic optical fibers and molecularly imprinted polymers. The case of PFBS detection , 2019, 2019 IEEE International Symposium on Measurements & Networking (M&N).

[50]  Chuyang Y. Tang,et al.  Use of reverse osmosis membranes to remove perfluorooctane sulfonate (PFOS) from semiconductor wastewater. , 2006, Environmental science & technology.

[51]  Scott A Mabury,et al.  Isolating isomers of perfluorocarboxylates in polar bears (Ursus maritimus) from two geographical locations. , 2004, Environmental science & technology.

[52]  Lakhwinder S Hundal,et al.  Occurrence and fate of perfluorochemicals in soil following the land application of municipal biosolids. , 2011, Environmental science & technology.

[53]  Lihua Zhu,et al.  Rapid fluorometric determination of perfluorooctanoic acid by its quenching effect on the fluorescence of quantum dots , 2015 .

[54]  M. Botelho,et al.  Solid Vapor Pressure and Enthalpy of Sublimation for Perfluorooctanoic Acid , 2008 .

[55]  Brendan O'Flynn,et al.  DEPLOY: a long term deployment of a water quality sensor monitoring system , 2012 .

[56]  J. Caixach,et al.  Occurrence of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in N.E. Spanish surface waters and their removal in a drinking water treatment plant that combines conventional and advanced treatments in parallel lines. , 2013, The Science of the total environment.

[57]  Leo W.Y. Yeung,et al.  Towards a comprehensive analytical workflow for the chemical characterisation of organofluorine in consumer products and environmental samples , 2020 .

[58]  P. Venkateswarlu Sodium biphenyl method for determination of covalently bound fluorine in organic compounds and biological materials. , 1982, Analytical chemistry.

[59]  Dominik Fiedler,et al.  Perfluoroalkyl and polyfluoroalkyl substances in consumer products , 2015, Environmental Science and Pollution Research.

[60]  Pawel Rostkowski,et al.  Trace analysis of total fluorine in human blood using combustion ion chromatography for fluorine: a mass balance approach for the determination of known and unknown organofluorine compounds. , 2007, Journal of chromatography. A.

[61]  Tsuyoshi Okazawa,et al.  Analysis of fluorotelomer alcohols, fluorotelomer acids, and short- and long-chain perfluorinated acids in water and biota. , 2005, Journal of chromatography. A.

[62]  James Franklin,et al.  Perfluoroalkyl and Polyfluoroalkyl Substances in the Environment: Terminology, Classification, and Origins , 2011, Integrated environmental assessment and management.

[63]  C. Rosin,et al.  Simultaneous determination of perfluoroalkyl iodides, perfluoroalkane sulfonamides, fluorotelomer alcohols, fluorotelomer iodides and fluorotelomer acrylates and methacrylates in water and sediments using solid-phase microextraction-gas chromatography/mass spectrometry. , 2016, Journal of chromatography. A.

[64]  Hian Kee Lee,et al.  An alternative perspective of hollow fiber-mediated extraction: Bundled hollow fiber array-liquid-phase microextraction with sonication-assisted desorption and liquid chromatography-tandem mass spectrometry for determination of estrogens in aqueous matrices. , 2017, Journal of chromatography. A.

[65]  Sara Bogialli,et al.  Electrochemosensor for Trace Analysis of Perfluorooctanesulfonate in Water Based on a Molecularly Imprinted Poly( o-phenylenediamine) Polymer. , 2018, ACS sensors.

[66]  S. Barreca,et al.  Online Solid-Phase Extraction LC-MS/MS: A Rapid and Valid Method for the Determination of Perfluorinated Compounds at Sub ng·L−1 Level in Natural Water , 2018, Journal of Chemistry.

[67]  J. Gulliver,et al.  Perfluoroalkyl acids in urban stormwater runoff: influence of land use. , 2012, Water research.

[68]  W. Lee,et al.  In situ 2D maps of pH shifts across brass–lead galvanic joints using microelectrodes , 2017, Measurement science & technology.

[69]  C. Higgins,et al.  Subsurface transport potential of perfluoroalkyl acids at aqueous film-forming foam (AFFF)-impacted sites. , 2013, Environmental science & technology.

[70]  R. R. Giri,et al.  Factors influencing UV photodecomposition of perfluorooctanoic acid in water , 2012 .

[71]  P. Bishop,et al.  Effect of free ammonia concentration on monochloramine penetration within a nitrifying biofilm and its effect on activity, viability, and recovery. , 2012, Water research.

[72]  K. Bielicka-Daszkiewicz Extraction techniques based on solid state and connected with liquid chromatography , 2016 .

[73]  R. Naidu,et al.  Gold nanoparticle-based optical sensors for selected anionic contaminants , 2017 .

[74]  M. Oehme,et al.  Comparison of Three Types of Mass Spectrometer for High-Performance Liquid Chromatography/Mass Spectrometry Analysis of Perfluoroalkylated Substances and Fluorotelomer Alcohols , 2004, European journal of mass spectrometry.

[75]  W. Xia,et al.  Sensitive bioassay for detection of PPARα potentially hazardous ligands with gold nanoparticle probe. , 2011, Journal of hazardous materials.

[76]  David Sanders Environmental sensors and networks of sensors , 2008 .

[77]  J. Bonde,et al.  Perfluoroalkyl and polyfluoroalkyl substances and human fetal growth: A systematic review , 2015, Critical reviews in toxicology.

[78]  Pawel Rostkowski,et al.  Determination of trace levels of total fluorine in water using combustion ion chromatography for fluorine: a mass balance approach to determine individual perfluorinated chemicals in water. , 2007, Journal of chromatography. A.

[79]  S. Lo,et al.  Recovery of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) from dilute water solution by foam flotation , 2017 .

[80]  Yaqi Cai,et al.  A highly selective dispersive liquid-liquid microextraction approach based on the unique fluorous affinity for the extraction and detection of per- and polyfluoroalkyl substances coupled with high performance liquid chromatography tandem-mass spectrometry. , 2018, Journal of chromatography. A.

[81]  C. Criddle,et al.  Quantitative determination of perfluorochemicals in sediments and domestic sludge. , 2005, Environmental science & technology.

[82]  P. Bishop,et al.  In situ microscale analyses of activated sludge flocs in the enhanced biological phosphate removal process by the use of microelectrodes and fluorescent in situ hybridization. , 2010 .

[83]  C. Higgins,et al.  Nanofiltration and granular activated carbon treatment of perfluoroalkyl acids. , 2013, Journal of hazardous materials.

[84]  Huimin Zhao,et al.  Electrochemical Biosensor for Detection of Perfluorooctane Sulfonate Based on Inhibition Biocatalysis of Enzymatic Fuel Cell , 2014 .

[85]  Marek Trojanowicz,et al.  Recent developments in methods for analysis of perfluorinated persistent pollutants , 2013, Microchimica Acta.

[86]  Luigi Zeni,et al.  A Molecularly Imprinted Polymer on a Plasmonic Plastic Optical Fiber to Detect Perfluorinated Compounds in Water , 2018, Sensors.

[87]  Woo Hyoung Lee,et al.  Biological Application of Micro‐Electro Mechanical Systems Microelectrode Array Sensors for Direct Measurement of Phosphate in the Enhanced Biological Phosphorous Removal Process , 2009, Water environment research : a research publication of the Water Environment Federation.

[88]  P. Peura,et al.  Quantitative gas chromatographic determination of perfluorooctanoic acid as the benzyl ester in plasma and urine , 1985, Archives of environmental contamination and toxicology.

[89]  K. Shih,et al.  Perfluorochemicals in wastewater treatment plants and sediments in Hong Kong. , 2010, Environmental pollution.

[90]  A. Minett,et al.  Micro solid-phase extraction for the analysis of per- and polyfluoroalkyl substances in environmental waters. , 2019, Journal of Chromatography A.

[91]  Shunqing Xu,et al.  A rapid and high-throughput quantum dots bioassay for monitoring of perfluorooctane sulfonate in environmental water samples. , 2011, Environmental pollution.

[92]  Urs Berger,et al.  Trace analysis of per- and polyfluorinated alkyl substances in various matrices-how do current methods perform? , 2009, Journal of chromatography. A.

[93]  H. Cho,et al.  A Novel Bismuth-Chitosan Nanocomposite Sensor for Simultaneous Detection of Pb(II), Cd(II) and Zn(II) in Wastewater , 2019, Micromachines.

[94]  Keita Saito,et al.  Determination of perfluorooctanoic acid and perfluorooctane sulfonate by automated in-tube solid-phase microextraction coupled with liquid chromatography-mass spectrometry. , 2010, Analytica chimica acta.

[95]  Jae-Hoon Hwang,et al.  Enhanced Electrochemical Detection of Multiheavy Metal Ions Using a Biopolymer-Coated Planar Carbon Electrode , 2019, IEEE Transactions on Instrumentation and Measurement.

[96]  Scott A Mabury,et al.  Monitoring perfluorinated surfactants in biota and surface water samples following an accidental release of fire-fighting foam into Etobicoke Creek. , 2002, Environmental science & technology.

[97]  Jae-Hoon Hwang,et al.  Enhanced electrochemical detection of multi-heavy metal ions using a biopolymer-coated planar carbon electrode , 2018, 2018 IEEE Sensors Applications Symposium (SAS).

[98]  P. Bishop,et al.  Characterization and application of a chlorine microelectrode for measuring monochloramine within a biofilm , 2010 .

[99]  Shigeo Fujii,et al.  Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) in sewage treatment plants. , 2009, Water research.

[100]  Hian Kee Lee,et al.  Automated bundled hollow fiber array-liquid-phase microextraction with liquid chromatography tandem mass spectrometric analysis of perfluorinated compounds in aqueous media. , 2018, Analytica chimica acta.

[101]  Shinsuke Tanabe,et al.  Perfluorooctanesulfonate and perfluorooctanoate in raw and treated tap water from Osaka, Japan. , 2008, Chemosphere.

[102]  Aimin Li,et al.  Molecularly imprinted ultrathin graphitic carbon nitride nanosheets-Based electrochemiluminescence sensing probe for sensitive detection of perfluorooctanoic acid. , 2015, Analytica chimica acta.

[103]  C. González-Barreiro,et al.  Method optimization for determination of selected perfluorinated alkylated substances in water samples , 2006, Analytical and bioanalytical chemistry.

[104]  Zhanyun Wang,et al.  A Never-Ending Story of Per- and Polyfluoroalkyl Substances (PFASs)? , 2017, Environmental science & technology.

[105]  Q. Cai,et al.  Molecularly imprinted polymer modified TiO2 nanotube arrays for photoelectrochemical determination of perfluorooctane sulfonate (PFOS) , 2014 .

[106]  S. Chadalavada,et al.  Recent advances in the analysis of per- and polyfluoroalkyl substances (PFAS)—A review , 2020 .

[107]  G. Ying,et al.  Perfluoroalkyl substances (PFASs) in wastewater treatment plants and drinking water treatment plants: Removal efficiency and exposure risk. , 2016, Water research.

[108]  W. Lee,et al.  Three-Dimensional Free Chlorine and Monochloramine Biofilm Penetration: Correlating Penetration with Biofilm Activity and Viability. , 2018, Environmental science & technology.

[109]  Christopher P. Higgins,et al.  Measuring Total PFASs in Water: The Tradeoff between Selectivity and Inclusivity. , 2019, Current opinion in environmental science & health.

[110]  W. Lee,et al.  Monochloramine-sensitive amperometric microelectrode: optimization of gold, platinum, and carbon fiber sensing materials for removal of dissolved oxygen interference , 2015, Ionics.