Age-related axonal swellings precede other neuropathological hallmarks in a knock-in mouse model of Huntington's disease

[1]  S. Dunnett,et al.  Mouse Models of Huntington's Disease. , 2015, Current topics in behavioral neurosciences.

[2]  A. Hannan,et al.  Dysregulation of synaptic proteins, dendritic spine abnormalities and pathological plasticity of synapses as experience-dependent mediators of cognitive and psychiatric symptoms in Huntington’s disease , 2013, Neuroscience.

[3]  G. Ellis‐Davies,et al.  In vivo characterization of a bigenic fluorescent mouse model of Alzheimer's disease with neurodegeneration. , 2013, The Journal of comparative neurology.

[4]  Michael I. Miller,et al.  Spatiotemporal mapping of brain atrophy in mouse models of Huntington's disease using longitudinal in vivo magnetic resonance imaging , 2012, NeuroImage.

[5]  M. Chesselet,et al.  Striatal atrophy and dendritic alterations in a knock-in mouse model of Huntington's disease , 2012, Brain Research Bulletin.

[6]  Å. Petersén,et al.  Hypothalamic and Limbic System Changes in Huntington's Disease. , 2012, Journal of Huntington's disease.

[7]  L. Menalled,et al.  Knock-in mouse models of Huntington’s disease , 2005, NeuroRX.

[8]  Francisco Clascá,et al.  Mapping of fluorescent protein-expressing neurons and axon pathways in adult and developing Thy1-eYFP-H transgenic mice , 2010, Brain Research.

[9]  Shihua Li,et al.  Huntingtin-associated Protein-1 Interacts with Pro-brain-derived Neurotrophic Factor and Mediates Its Transport and Release* , 2009, The Journal of Biological Chemistry.

[10]  Chun-Fang Huang,et al.  Pathogenic Huntingtin Inhibits Fast Axonal Transport by Activating JNK3 and Phosphorylating Kinesin , 2009, Nature Neuroscience.

[11]  J. Marsh,et al.  Live axonal transport disruption by mutant huntingtin fragments in Drosophila motor neuron axons , 2009, Neurobiology of Disease.

[12]  Kurt E. Weaver,et al.  Longitudinal diffusion tensor imaging in Huntington's Disease , 2009, Experimental Neurology.

[13]  A. Nógrádi,et al.  Severely dystrophic axons at amyloid plaques remain continuous and connected to viable cell bodies. , 2009, Brain : a journal of neurology.

[14]  R. Ribchester,et al.  Late onset distal axonal swelling in YFP-H transgenic mice , 2009, Neurobiology of Aging.

[15]  A. J. Morton,et al.  Use of magnetic resonance imaging for anatomical phenotyping of the R6/2 mouse model of Huntington's disease , 2009, Neurobiology of Disease.

[16]  M. Chesselet,et al.  Extensive early motor and non-motor behavioral deficits are followed by striatal neuronal loss in knock-in Huntington's disease mice , 2008, Neuroscience.

[17]  He Li,et al.  N-Terminal Mutant Huntingtin Associates with Mitochondria and Impairs Mitochondrial Trafficking , 2008, The Journal of Neuroscience.

[18]  A. Giralt,et al.  Disruption of striatal glutamatergic transmission induced by mutant huntingtin involves remodeling of both postsynaptic density and NMDA receptor signaling , 2008, Neurobiology of Disease.

[19]  J. Glass,et al.  NAD+ and axon degeneration revisited: Nmnat1 cannot substitute for WldS to delay Wallerian degeneration , 2007, Cell Death and Differentiation.

[20]  G. Pigino,et al.  JNK mediates pathogenic effects of polyglutamine-expanded androgen receptor on fast axonal transport , 2006, Nature Neuroscience.

[21]  Sarah A. J. Reading,et al.  Regional white matter change in pre-symptomatic Huntington's disease: A diffusion tensor imaging study , 2005, Psychiatry Research: Neuroimaging.

[22]  Steven M Hersch,et al.  Chronology of behavioral symptoms and neuropathological sequela in R6/2 Huntington's disease transgenic mice , 2005, The Journal of comparative neurology.

[23]  P. Brundin,et al.  Synaptic dysfunction in Huntington’s disease: a new perspective , 2005, Cellular and Molecular Life Sciences CMLS.

[24]  M. Hayden,et al.  Cognitive Dysfunction Precedes Neuropathology and Motor Abnormalities in the YAC128 Mouse Model of Huntington's Disease , 2005, The Journal of Neuroscience.

[25]  Mark R. Segal,et al.  Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death , 2004, Nature.

[26]  Jaime Grutzendler,et al.  Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches , 2004, Nature Neuroscience.

[27]  Shihua Li,et al.  Huntington and its Role in Neuronal Degeneration , 2004, The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.

[28]  E. Seeberg,et al.  Mutant Huntingtin Impairs Axonal Trafficking in Mammalian Neurons In Vivo and In Vitro , 2004, Molecular and Cellular Biology.

[29]  Fabrice P Cordelières,et al.  Huntingtin Controls Neurotrophic Support and Survival of Neurons by Enhancing BDNF Vesicular Transport along Microtubules , 2004, Cell.

[30]  J. Littleton,et al.  Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a Drosophila model of Huntington's disease. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[31]  M. Chesselet,et al.  Time course of early motor and neuropathological anomalies in a knock‐in mouse model of Huntington's disease with 140 CAG repeats , 2003, The Journal of comparative neurology.

[32]  Richard G. Brusch,et al.  Disruption of Axonal Transport by Loss of Huntingtin or Expression of Pathogenic PolyQ Proteins in Drosophila , 2003, Neuron.

[33]  He Li,et al.  Abnormal association of mutant huntingtin with synaptic vesicles inhibits glutamate release. , 2003, Human molecular genetics.

[34]  Carlos Cepeda,et al.  Transient and Progressive Electrophysiological Alterations in the Corticostriatal Pathway in a Mouse Model of Huntington's Disease , 2003, The Journal of Neuroscience.

[35]  M. Chesselet,et al.  Electrophysiological and morphological changes in striatal spiny neurons in R6/2 Huntington's disease transgenic mice. , 2001, Journal of neurophysiology.

[36]  H Li,et al.  Huntingtin Aggregate-Associated Axonal Degeneration is an Early Pathological Event in Huntington's Disease Mice , 2001, The Journal of Neuroscience.

[37]  R. Wetzel,et al.  Polyglutamine aggregation behavior in vitro supports a recruitment mechanism of cytotoxicity. , 2001, Journal of molecular biology.

[38]  G. Feng,et al.  Imaging Neuronal Subsets in Transgenic Mice Expressing Multiple Spectral Variants of GFP , 2000, Neuron.

[39]  S B Dunnett,et al.  Abnormal Synaptic Plasticity and Impaired Spatial Cognition in Mice Transgenic for Exon 1 of the Human Huntington's Disease Mutation , 2000, The Journal of Neuroscience.

[40]  J Q Trojanowski,et al.  Axon pathology in Parkinson's disease and Lewy body dementia hippocampus contains alpha-, beta-, and gamma-synuclein. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[41]  R. Myers,et al.  Impaired synaptic plasticity in mice carrying the Huntington's disease mutation. , 1999, Human molecular genetics.

[42]  Claire-Anne Gutekunst,et al.  Nuclear and Neuropil Aggregates in Huntington’s Disease: Relationship to Neuropathology , 1999, The Journal of Neuroscience.

[43]  J. Penney,et al.  Axonal transport of N-terminal huntingtin suggests early pathology of corticostriatal projections in Huntington disease. , 1999, Journal of neuropathology and experimental neurology.

[44]  G. M. Halliday,et al.  Regional Specificity of Brain Atrophy in Huntington's Disease , 1998, Experimental Neurology.

[45]  Steven Finkbeiner,et al.  Huntingtin Acts in the Nucleus to Induce Apoptosis but Death Does Not Correlate with the Formation of Intranuclear Inclusions , 1998, Cell.

[46]  S. W. Davies,et al.  Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain. , 1997, Science.

[47]  Mark Turmaine,et al.  Formation of Neuronal Intranuclear Inclusions Underlies the Neurological Dysfunction in Mice Transgenic for the HD Mutation , 1997, Cell.

[48]  V. Perry,et al.  Axonal damage in acute multiple sclerosis lesions. , 1997, Brain : a journal of neurology.

[49]  S. W. Davies,et al.  Exon 1 of the HD Gene with an Expanded CAG Repeat Is Sufficient to Cause a Progressive Neurological Phenotype in Transgenic Mice , 1996, Cell.

[50]  T. Robbins,et al.  Executive and mnemonic functions in early Huntington's disease. , 1996, Brain : a journal of neurology.

[51]  E. Siemers,et al.  Cognitive scores in carriers of huntington's disease gene compared to noncarriers , 1995, Annals of neurology.

[52]  C. Marsden,et al.  Comparison of executive and visuospatial memory function in Huntington's disease and dementia of Alzheimer type matched for degree of dementia. , 1995, Journal of neurology, neurosurgery, and psychiatry.

[53]  Manish S. Shah,et al.  A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes , 1993, Cell.

[54]  J. Penney,et al.  Preferential loss of striato‐external pallidal projection neurons in presymptomatic Huntington's disease , 1992, Annals of neurology.

[55]  N. Kowall,et al.  Neurofilament and neural cell adhesion molecule immunocytochemistry of Huntington's disease striatum , 1992, Annals of neurology.

[56]  N W Kowall,et al.  Proliferative and degenerative changes in striatal spiny neurons in Huntington's disease: a combined study using the section-Golgi method and calbindin D28k immunocytochemistry , 1991, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[57]  E. Mohr,et al.  Visuospatial cognition in Huntington's disease , 1991, Movement disorders : official journal of the Movement Disorder Society.

[58]  J. Penney,et al.  Differential loss of striatal projection neurons in Huntington disease. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[59]  J. B. Martin,et al.  Selective sparing of a class of striatal neurons in Huntington's disease. , 1985, Science.

[60]  R. Ferrante,et al.  Neuropathological Classification of Huntington's Disease , 1985, Journal of neuropathology and experimental neurology.

[61]  G. Graveland,et al.  Evidence for degenerative and regenerative changes in neostriatal spiny neurons in Huntington's disease. , 1985, Science.

[62]  F. A. Putt,et al.  Histopathologic Technic and Practical Histochemistry , 1954, The Yale Journal of Biology and Medicine.