A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells

[1]  T. Marquès-Bonet,et al.  Limiting replication stress during somatic cell reprogramming reduces genomic instability in induced pluripotent stem cells , 2015, Nature Communications.

[2]  Raquel Herrador,et al.  Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells , 2015, The Journal of cell biology.

[3]  M. Lopes,et al.  Replication fork reversal in eukaryotes: from dead end to dynamic response , 2015, Nature Reviews Molecular Cell Biology.

[4]  David A. Williams,et al.  Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells , 2015, Nature.

[5]  A. Morris,et al.  Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions , 2015, BDJ.

[6]  B. Vogelstein,et al.  Variation in cancer risk among tissues can be explained by the number of stem cell divisions , 2015, Science.

[7]  Jiri Bartek,et al.  TRIP12 and UBR5 Suppress Spreading of Chromatin Ubiquitylation at Damaged Chromosomes , 2014, Cell.

[8]  M. L. Beau,et al.  Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells , 2014, Nature.

[9]  Sang-Wook Yoon,et al.  Rad51 regulates cell cycle progression by preserving G2/M transition in mouse embryonic stem cells. , 2014, Stem cells and development.

[10]  M. Kirschner,et al.  Molecular ties between the cell cycle and differentiation in embryonic stem cells , 2014, Proceedings of the National Academy of Sciences of the United States of America.

[11]  Kazumasa Yoshida,et al.  The histone deacetylases sir2 and rpd3 act on ribosomal DNA to control the replication program in budding yeast. , 2014, Molecular cell.

[12]  F. Lanner.  Lineage specification in the early mouse embryo. , 2014, Experimental cell research.

[13]  J Julian Blow,et al.  Deregulated origin licensing leads to chromosomal breaks by rereplication of a gapped DNA template , 2013, Genes & development.

[14]  A. Carr,et al.  Replication stress-induced genome instability: the dark side of replication maintenance by homologous recombination. , 2013, Journal of molecular biology.

[15]  D. Maiorano,et al.  High Dub3 expression in mouse ESCs couples the G1/S checkpoint to pluripotency. , 2013, Molecular cell.

[16]  B. Blagoev,et al.  The chromatin scaffold protein SAFB1 renders chromatin permissive for DNA damage signaling. , 2013, Molecular cell.

[17]  Yi Zhang,et al.  TET enzymes, TDG and the dynamics of DNA demethylation , 2013, Nature.

[18]  I. Hickson,et al.  How unfinished business from S‐phase affects mitosis and beyond , 2013, The EMBO journal.

[19]  Raquel Herrador,et al.  Oncogenes induce genotoxic stress by mitotic processing of unusual replication intermediates , 2013, The Journal of cell biology.

[20]  David M. Wilson,et al.  Pathways for repairing and tolerating the spectrum of oxidative DNA lesions. , 2012, Cancer letters.

[21]  G. Babcock,et al.  The abundance of Rad51 protein in mouse embryonic stem cells is regulated at multiple levels. , 2012, Stem cell research.

[22]  M. Kirschner,et al.  Gap 1 phase length and mouse embryonic stem cell self-renewal , 2012, Proceedings of the National Academy of Sciences.

[23]  P. Circosta,et al.  High Basal γH2AX Levels Sustain Self‐Renewal of Mouse Embryonic and Induced Pluripotent Stem Cells , 2012, Stem cells.

[24]  M. Foiani,et al.  Preventing replication stress to maintain genome stability: resolving conflicts between replication and transcription. , 2012, Molecular cell.

[25]  Raquel Herrador,et al.  Topoisomerase I poisoning results in PARP-mediated replication fork reversal , 2012, Nature Structural &Molecular Biology.

[26]  G. Daley,et al.  Cell cycle adaptations of embryonic stem cells , 2011, Proceedings of the National Academy of Sciences.

[27]  James R Bischoff,et al.  A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations , 2011, Nature Structural &Molecular Biology.

[28]  P G Pelicci,et al.  Genomic instability in induced stem cells , 2011, Cell Death and Differentiation.

[29]  B. Kerem,et al.  Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development , 2011, Cell.

[30]  M. Pera,et al.  Stem cells: The dark side of induced pluripotency , 2011, Nature.

[31]  B. Neumann,et al.  53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress , 2011, Nature Cell Biology.

[32]  R. Scott Hansen,et al.  Cell-type-specific replication initiation programs set fragility of the FRA3B fragile site , 2011, Nature.

[33]  G. Schatten,et al.  DNA Damage Responses in Human Induced Pluripotent Stem Cells and Embryonic Stem Cells , 2010, PloS one.

[34]  S. Dalton,et al.  Evolutionarily conserved replication timing profiles predict long-range chromatin interactions and distinguish closely related cell types. , 2010, Genome research.

[35]  T. Hunt,et al.  Loss of the mammalian APC/C activator FZR1 shortens G1 and lengthens S phase but has little effect on exit from mitosis , 2009, Journal of Cell Science.

[36]  E. Laurenti,et al.  Balancing dormant and self-renewing hematopoietic stem cells. , 2009, Current opinion in genetics & development.

[37]  A. Helmrich,et al.  Distribution of p53 binding protein 1 (53BP1) and phosphorylated H2A.X during mouse preimplantation development in the absence of DNA damage. , 2009, The International journal of developmental biology.

[38]  P. Lansdorp,et al.  Explanation for excessive DNA single-strand breaks and endogenous repair foci in pluripotent mouse embryonic stem cells. , 2009, Experimental cell research.

[39]  M. Stojkovic,et al.  A role for NANOG in G1 to S transition in human embryonic stem cells through direct binding of CDK6 and CDC25A , 2009, The Journal of cell biology.

[40]  S. Takebayashi,et al.  PARP-1 ensures regulation of replication fork progression by homologous recombination on damaged DNA , 2008, The Journal of cell biology.

[41]  Dirk Schübeler,et al.  Global Reorganization of Replication Domains During Embryonic Stem Cell Differentiation , 2008, PLoS biology.

[42]  V. Pospelov,et al.  Activation of DNA damage response signaling in mouse embryonic stem cells , 2008, Cell cycle.

[43]  P. Stambrook,et al.  DNA repair in murine embryonic stem cells and differentiated cells. , 2008, Experimental cell research.

[44]  G. Stein,et al.  Self‐renewal of human embryonic stem cells is supported by a shortened G1 cell cycle phase , 2006, Journal of cellular physiology.

[45]  Hisao Masai,et al.  Cell Cycle and Developmental Regulations of Replication Factors in Mouse Embryonic Stem Cells* , 2005, Journal of Biological Chemistry.

[46]  S. Dalton,et al.  Developmental activation of the Rb-E2F pathway and establishment of cell cycle-regulated cyclin-dependent kinase activity during embryonic stem cell differentiation. , 2005, Molecular biology of the cell.

[47]  P. Stambrook,et al.  Restoration of an absent G1 arrest and protection from apoptosis in embryonic stem cells after ionizing radiation. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[48]  Bruce Stillman,et al.  Deregulation of cyclin E in human cells interferes with prereplication complex assembly , 2004, The Journal of cell biology.

[49]  Bruce Stillman,et al.  Chromatin Association of Human Origin Recognition Complex, Cdc6, and Minichromosome Maintenance Proteins during the Cell Cycle: Assembly of Prereplication Complexes in Late Mitosis , 2000, Molecular and Cellular Biology.

[50]  G. Wahl,et al.  ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage , 1998, Current Biology.

[51]  K. Nakao,et al.  Targeted disruption of the Rad51 gene leads to lethality in embryonic mice. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[52]  L. Szekely,et al.  Contrasting patterns of retinoblastoma protein expression in mouse embryonic stem cells and embryonic fibroblasts. , 1994, Oncogene.

[53]  Cindy Follonier,et al.  Visualization and interpretation of eukaryotic DNA replication intermediates in vivo by electron microscopy. , 2014, Methods in molecular biology.

[54]  Oliver H. Tam,et al.  Mechanisms of pluripotency in vivo and in vitro. , 2014, Current topics in developmental biology.

[55]  P. Stambrook,et al.  Preservation of genomic integrity in mouse embryonic stem cells. , 2010, Advances in experimental medicine and biology.

[56]  I. Ial,et al.  Nature Communications , 2010, Nature Cell Biology.