High serum adiponectin is associated with low blood haemoglobin in elderly men: the Swedish MrOS study

Blood haemoglobin (Hb) concentration declines in elderly men, whilst the level of the adipocyte‐derived protein adiponectin increases with age. The association between erythropoiesis and adiponectin in elderly men is unclear. The aim of this study was to determine whether adipokines such as adiponectin and leptin are associated with anaemia and Hb concentration in elderly community‐dwelling men.

[1]  M. Ruchała,et al.  Anemia in thyroid diseases. , 2017, Polish archives of internal medicine.

[2]  F. Harrell General Aspects of Fitting Regression Models , 2015 .

[3]  B. Cortet,et al.  Bone marrow fat. , 2014, Joint, bone, spine : revue du rhumatisme.

[4]  E. Barrett-Connor,et al.  Serum estradiol associates with blood hemoglobin in elderly men: the MrOS Sweden study. , 2014, The Journal of clinical endocrinology and metabolism.

[5]  Takeo Kato,et al.  Management of erythropoiesis: cross‐sectional study of the relationships between erythropoiesis and nutrition, physical features, and adiponectin in 3519 Japanese people , 2014, European journal of haematology.

[6]  J. Lord,et al.  Adiponectin inhibits neutrophil apoptosis via activation of AMP kinase, PKB and ERK 1/2 MAP kinase , 2013, Apoptosis.

[7]  D. Mellström,et al.  Holotranscobalamin is not influenced by decreased renal function in elderly men: the MrOS Sweden study , 2013, Annals of clinical biochemistry.

[8]  R. DePinho,et al.  Adiponectin regulates bone mass via opposite central and peripheral mechanisms through FoxO1. , 2013, Cell metabolism.

[9]  S. Bandinelli,et al.  Metabolic Syndrome and Hemoglobin Levels in Elderly Adults: The Invecchiare in Chianti Study , 2013, Journal of the American Geriatrics Society.

[10]  R. Allman,et al.  Low Hemoglobin Levels and Recurrent Falls in U.S. Men and Women: Prospective Findings from the REasons for Geographic And Racial Differences in Stroke (REGARDS) Cohort , 2013, The American journal of the medical sciences.

[11]  G. Vassilopoulos,et al.  Metabolism-Related Cytokine and Hormone Levels in the Serum of Patients with Myelodysplastic Syndromes , 2013, Acta Haematologica.

[12]  K. Fukuo,et al.  Anemia and reduced renal function are independent predictors of elevated serum adiponectin in elderly women. , 2013, Journal of atherosclerosis and thrombosis.

[13]  K. Kohara,et al.  Hematological parameters are associated with metabolic syndrome in Japanese community-dwelling persons , 2013, Endocrine.

[14]  E. Hsiao,et al.  Activated Gs signaling in osteoblastic cells alters the hematopoietic stem cell niche in mice. , 2012, Blood.

[15]  M. Petzold,et al.  Both low and high serum IGF-I levels associate with cancer mortality in older men. , 2012, Journal of Clinical Endocrinology and Metabolism.

[16]  S. Kihara,et al.  Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. 1999. , 2012, Biochemical and biophysical research communications.

[17]  J. Kanis,et al.  High serum adiponectin predicts incident fractures in elderly men: Osteoporotic fractures in men (MrOS) Sweden , 2012, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[18]  E. Rankin,et al.  The HIF Signaling Pathway in Osteoblasts Directly Modulates Erythropoiesis through the Production of EPO , 2012, Cell.

[19]  A. Shehzad,et al.  Adiponectin: Regulation of its production and its role in human diseases , 2012, Hormones.

[20]  C. Combescure,et al.  Influence of adipokines and ghrelin on bone mineral density and fracture risk: a systematic review and meta-analysis. , 2011, The Journal of clinical endocrinology and metabolism.

[21]  J. Cauley,et al.  Adipokines and the risk of fracture in older adults , 2011, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[22]  G. Bergström,et al.  Adiponectin in relation to insulin sensitivity and insulin secretion in the development of type 2 diabetes: a prospective study in 64‐year‐old women , 2011, Journal of internal medicine.

[23]  Carl R Walkley Erythropoiesis, anemia and the bone marrow microenvironment , 2011, International journal of hematology.

[24]  K. Kohara,et al.  Hemoglobin is associated with serum high molecular weight adiponectin in Japanese community-dwelling persons. , 2011, Journal of atherosclerosis and thrombosis.

[25]  S. Price,et al.  Adiponectin is produced by lymphocytes and is a negative regulator of granulopoiesis , 2010, Journal of leukocyte biology.

[26]  B. Zinman,et al.  Association of hematological parameters with insulin resistance and beta-cell dysfunction in nondiabetic subjects. , 2009, The Journal of clinical endocrinology and metabolism.

[27]  K. Hara,et al.  Anemia is associated with an elevated serum level of high-molecular-weight adiponectin in patients with type 2 diabetes independently of renal dysfunction. , 2009, Translational research : the journal of laboratory and clinical medicine.

[28]  G. Daley,et al.  Bone marrow adipocytes as negative regulators of the hematopoietic microenvironment , 2009, Nature.

[29]  T. Pang,et al.  The Distribution of Adiponectin Receptors on Human Peripheral Blood Mononuclear Cells , 2008, Annals of the New York Academy of Sciences.

[30]  D. Mellström,et al.  Older Men With Low Serum Estradiol and High Serum SHBG Have an Increased Risk of Fractures , 2008, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[31]  R. Lipton,et al.  Adiponectin levels and genotype: a potential regulator of life span in humans. , 2008, The journals of gerontology. Series A, Biological sciences and medical sciences.

[32]  C. Voermans,et al.  Identification of Adiponectin as a Novel Hemopoietic Stem Cell Growth Factor1 , 2007, The Journal of Immunology.

[33]  Luigi Ferrucci,et al.  Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia. , 2004, Blood.

[34]  A. Häkkinen,et al.  Effects of rosiglitazone and metformin on liver fat content, hepatic insulin resistance, insulin clearance, and gene expression in adipose tissue in patients with type 2 diabetes. , 2004, Diabetes.

[35]  Shinji Katayose,et al.  Relationships between plasma adiponectin and blood cells, hepatopancreatic enzymes in women , 2004, Thrombosis and Haemostasis.

[36]  L. Mosekilde,et al.  Adipocyte tissue volume in bone marrow is increased with aging and in patients with osteoporosis , 2004, Biogerontology.

[37]  T. Funahashi,et al.  Adiponectin, a Fat Cell Product, Influences the Earliest Lymphocyte Precursors in Bone Marrow Cultures by Activation of the Cyclooxygenase-Prostaglandin Pathway in Stromal Cells 1 , 2003, The Journal of Immunology.

[38]  Philippe Froguel,et al.  Cloning of adiponectin receptors that mediate antidiabetic metabolic effects , 2003, Nature.

[39]  M. Cnop,et al.  Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex , 2003, Diabetologia.

[40]  T. Funahashi,et al.  The Journal of Clinical Endocrinology & Metabolism Printed in U.S.A. Copyright © 2001 by The Endocrine Society Hypoadiponectinemia in Obesity and Type 2 Diabetes: Close Association with Insulin Resistance , 2022 .

[41]  R. Carmel,et al.  Anemia and aging: an overview of clinical, diagnostic and biological issues. , 2001, Blood reviews.

[42]  S. Kihara,et al.  Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages. , 2000, Blood.

[43]  D. Knook,et al.  The definition of anemia in older persons. , 1999, JAMA.

[44]  T Nakamura,et al.  Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. , 1999, Biochemical and biophysical research communications.

[45]  G. Reaven,et al.  Hematocrit and hemoglobin are independently related to insulin resistance and compensatory hyperinsulinemia in healthy, non-obese men and women. , 1998, Metabolism: clinical and experimental.

[46]  N. Haboubi,et al.  DECLINE OF BLOOD HAEMOGLOBIN IN THE AGED: A LONGITUDINAL STUDY OF AN URBAN SWEDISH POPULATION FROM AGE 70 TO 81 , 1989, British journal of haematology.

[47]  E. Beutner,et al.  Report of a WHO Scientific Group (Part 3 of 3) , 1973 .