On-Line Testing of Lab-on-Chip Using Digital Microfluidic Compactors

Dependability is an important system attribute for microfluidic lab-on-chip devices. On-line testing offers a promising method for detecting defects, fluidic abnormalities, and bioassay malfunctions during chip operation. However, previous techniques for reading test outcomes and analyzing pulse sequences are cumbersome, sensitive to the calibration of capacitive sensors, and error-prone. We present a built-in self-test (BIST) method for on-line testing of digital microfluidic lab-on-chip. This method utilizes microfluidic compactors based on droplet-based AND gates, which are implemented using digital microfluidics. Dynamic reconfiguration of these compactors ensures low area overhead and it allows BIST to be interleaved with bioassays in functional mode.

[1]  Hans G. Kerkhoff.  Testing Microelectronic Biofluidic Systems , 2007, IEEE Design & Test of Computers.

[2]  Fei Su,et al.  Digital Microfluidic Biochips - Synthesis, Testing, and Reconfiguration Techniques , 2006 .

[3]  Michael George Pollack,et al.  ELECTROWETTING-BASED MICROACTUATION OF DROPLETS FOR DIGITAL MICROFLUIDICS , 2001 .

[4]  Fei Su,et al.  Testing of droplet-based microelectrofluidic systems , 2003, International Test Conference, 2003. Proceedings. ITC 2003..

[5]  Krishnendu Chakrabarty,et al.  Design automation methods and tools for microfluidics-based biochips , 2006 .

[6]  Narayanan Vijaykrishnan,et al.  Priority Scheduling in Digital Microfluidics-Based Biochips , 2006, Proceedings of the Design Automation & Test in Europe Conference.

[7]  Toshinori Munakata,et al.  Micro/nanofluidic computing , 2007, CACM.

[8]  Yao-Wen Chang,et al.  Placement of digital microfluidic biochips using the T-tree formulation , 2006, 2006 43rd ACM/IEEE Design Automation Conference.

[9]  Krishnendu Chakrabarty,et al.  Parallel Scan-Like Test and Multiple-Defect Diagnosis for Digital Microfluidic Biochips , 2007, IEEE Transactions on Biomedical Circuits and Systems.

[10]  A. Berg,et al.  Micro Total Analysis Systems , 1995 .

[11]  Jack Zhou,et al.  Chemical and Biological Applications of Digital-Microfluidic Devices , 2007, IEEE Design & Test of Computers.

[12]  Fei Su,et al.  Testing and Diagnosis of Realistic Defects in Digital Microfluidic Biochips , 2007, J. Electron. Test..

[13]  R. Fair,et al.  CLINICAL DIAGNOSTICS ON HUMAN WHOLE BLOOD, PLASMA, SERUM, URINE, SALIVA, SWEAT, AND TEARS ON A DIGITAL MICROFLUIDIC PLATFORM , 2003 .

[14]  Tao Xu,et al.  Digital microfluidic biochip design for protein crystallization , 2007, 2007 IEEE/NIH Life Science Systems and Applications Workshop.

[15]  Krishnendu Chakrabarty,et al.  Functional testing of digital microfluidic biochips , 2007, 2007 IEEE International Test Conference.

[16]  Fei Su,et al.  Microfluidics-Based Biochips: Technology Issues, Implementation Platforms, and Design-Automation Challenges , 2006, IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems.

[17]  Krishnendu Chakrabarty.  COPLANAR DIGITAL MICROFLUIDICS USING STANDARD PRINTED CIRCUIT BOARD PROCESSES , 2005 .

[18]  Fei Su,et al.  Concurrent testing of droplet-based microfluidic systems for multiplexed biomedical assays , 2004 .